COBRE: UID: MOLECULAR & CELLULAR BASIS OF HOST PATHOGEN INTERACTIONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。通过促进我们的人员和基础设施基地的建设，COBRE在过去五年中的支持对爱达荷州大学的微生物发病机理研究产生了重大影响。除了在最初的资助期间增加了两名新的COBRE资助的研究人员外，我们的大学管理部门还与COBRE PI合作，在过去的四年中增加了四个终身职位。随着这一新的人才队伍和我们的COBRE教师的成功，我们已经朝着建立UI作为一个机构与国家认可的生物医学计划，重点是微生物发病机制取得了进展。在此基础上，我们提出了四个具体目标。具体目标1：扩大COBRE共同研究者核心小组的临界质量并扩大其科学多样性。在这个目标中，我们建议增加我们现有的COBRE团队，为最近聘请的教职员工提供研究支持，以及目前没有由NIH资助的更多的教职员工，以及一个待确定的额外人员。具体目标2：扩大和支持COBRE资助的核心设施。在COBRE和UI的支持下，我们能够利用私人资金建立几个最先进的核心设施，包括结构生物学，显微镜，细胞分离和基因组学核心设施。在本提案中，我们描述了扩大和/或支持这些设施的计划，以确保COBRE和UI的初始投资有效地增强了COBRE调查人员和校园内其他生物医学调查人员的研究。具体目标3：提高研究生/医科学生参与生物医学研究的质量和人数。自COBRE资助周期开始以来，随着我们能够招募到的高质量研究生的记录增加，我们将使用更多的COBRE资金来进一步加强我们的研究生招聘工作。这将通过提高津贴，促进在美国和国际上的招聘，以及与爱达荷州INBRE的研究生教育管道计划接口来实现。具体目标4：COBRE资金完成后，向美国国立卫生研究院的自我维持生物医学研究支持过渡。这一最终目标将有助于将COBRE研究人员确立为独立研究人员，最终目标是获得NIH的长期项目支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. By facilitating the building of our personnel and infrastructure bases, COBRE support over the past five years has had a significant impact on research in microbial pathogenesis at the University of Idaho. In addition to two new COBRE-funded investigators added during the initial funding period, our university administration has partnered with the COBRE PI to create four additional tenure-track positions during the past four years. With this new group of talented faculty and the success of our COBRE faculty we have made progress toward establishing the UI as an institution with a nationally recognized biomedical program with a focus on microbial pathogenesis. To build upon this success, we propose four specific aims. Specific Aim 1: Extend the critical mass and expand the scientific diversity of the core group of COBRE co-Investigators. In this aim we propose to add to our existing COBRE team by providing research support for the recently hired faculty members, as well as more established faculty members not currently funded by NIH, and an additional person to be identified. Specific Aim 2: Expand and support COBRE funded core facilities. With COBRE and UI support, we were able to leverage private funding to build several state-of-the-art core facilities, including Structural Biology, Microscopy, Cell Separation, and Genomics Core Facilities. In this proposal, we describe plans to expand and/or support these facilities to ensure that initial investments made by COBRE and the UI efficiently enhance research of COBRE investigators and other biomedical investigators on campus. Specific Aim 3: Enhance the quality and numbers of graduate/medical students to participate in biomedical research. With the documented increase in higher quality graduate students we have been able to recruit since the beginning of the COBRE funding cycle, we will use additional COBRE funds to further enhance our graduate recruiting efforts. This will be done by enhancing stipends, promoting recruitment in the U.S. and internationally, plus interfacing with the Idaho INBRE¿s ¿Pipeline to Graduate Education¿ program. Specific Aim 4: Transition toward self-sustaining biomedical research support from the National Institutes of Health following completion of COBRE funds. This final aim will help to establish the COBRE investigators as independent researchers with the ultimate goal of obtaining long-term program project support from the NIH.