MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS

虽然爱达荷大学从事生物医学研究的教师人数不多，但我们的机构坚定地致力于微生物发病机理和食源性疾病的研究。该项目的总体目标是建立在我们目前在“宿主-病原体相互作用的分子和细胞基础研究”方面的核心力量之上。我们将把科罗拉多大学建成一个拥有全国认可的生物医学项目的一流机构。COBRE的资金将使我们能够将几位已建立的生物医学科学家的项目与两名新的终身教职教师（病毒学家和细胞生物学家）的项目整合在一起。在此过程中，我们将强调中心所有教师的职业发展、指导和资助。我们将加强与博伊西退伍军人事务医疗中心传染病科的研究生培训和研究合作。最后，我们将把五个州（怀俄明州、华盛顿州、阿拉斯加州、蒙大拿州和爱达荷州）的WWAMI医学计划整合到COBRE中心，为医科学生提供一个沉浸在生物医学研究中的独特机会。COBRE中心的研究项目最初将由四名共同调查员领导，每位共同调查员都提出了一个与人类健康和中心总体主题相关的多学科研究领域。该团队及其合作者将在Gregory A. Bohach博士的管理和协作指导下工作，Gregory A. Bohach博士是微生物发病机理几个领域的研究者。四个独立互补的项目包括：1)大肠杆菌志贺毒素的抗病毒活性研究；2) Mx表达与子宫黏膜免疫；3)金黄色葡萄球菌被上皮细胞内化的机制及意义；4)磷脂酶c诱导气性坏疽的血小板-白细胞相互作用和渗出缺陷。除了这四个项目外，我们的新病毒学家和细胞生物学家将向COBRE中心和我们的顾问委员会提交研究建议，供其批准。已经制定了在终止COBRE支持后发展资金独立性的计划。

Although the number of faculty engaged in biomedical research at the University of Idaho (U of I) is not large, our institution is strongly committed to research related to microbial pathogenesis and food-borne illness. The overall objective of this project is to build upon our current core of strength in the "study of the molecular and cellular basis of host- pathogen interactions". We will establish the U of I as a premier institutional having a nationally recognized biomedical program with this thematic focus. COBRE funding will allow us to integrate the programs of several established biomedical scientists with those of tow new tenure- track faculty (a virologist and cell biologist) on the main campus in Moscow, ID. In doing so, we will emphasize career development, mentoring, and grantsmanship of all faculty in the Center. We will strengthen our graduate training and research collaboration with the Infectious Diseases Unit of Boise Veterans Affairs Medical Center. Finally, we will integrate the five-state (Wyoming, Washing, Alaska, Montana, and Idaho) WWAMI Medical Program into the COBRE Center to provide a unique opportunity for medical students to become immersed in biomedical research. COBRE center research projects will initially be led by four Co-Investigators , each of whom has proposed an area of multi-disciplinary research relevant to human health and to the overall theme of the Center. This team and their collaborators will work under the administrative and collaborative guidance of Dr. Gregory A. Bohach an investigator established in several areas of microbial pathogenesis. The four independent but complementary projects include: 1) An investigation of the anti-viral activity of Escherichia coli Shiga toxin; 2) Mx expression and uterine mucosal immunity; 3) The mechanism and significance of the internalization of Staphylococcus aureus by epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the COBRE Center and our Advisory Board for approval. A plan to develop funding independence following termination of COBRE support has been developed.