COBRE: UD: PROJ 3: EFFECT OF IN-SHOE WEDGES ON KNEE OSTEOARTHRITIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In-shoe wedges have been shown to be an effective conservative approach in reducing pain in patients with osteoarthritis. The mechanism responsible for this pain reduction is not well understood. The goal of this project is to investigate the effect of in-shoe wedged orthoses on lower extremity function in patients with knee osteoarthritis. In general, our aims address the immediate effects of orthoses, the long-term effects of orthoses, and the immediate and long-term treatment effects comparing medial versus lateral wedged orthoses. The organization of this project has been divided into three aims: Aim 1: Determine the immediate effect of in-shoe wedged orthoses on lower extremity alignment mechanics and functional status in subjects with knee joint OA. Aim 2: Determine the long-term effect of in-shoe wedged orthoses on lower extremity alignment, mechanics, and functional status in subjects with knee joint osteoarthritis. Aim 3: Determine the differential effects of lateral versus medial in-shoe wedged orthoses on lower extremity alignment, mechanics, and functional status in subjects with medial and lateral knee joint OA.