COBRE: UD: PROJ 3: EFFECT OF IN-SHOE WEDGES ON KNEE OSTEOARTHRITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 鞋内楔形物已被证明是一种有效的保守方法，可以减轻骨关节炎患者的疼痛。负责这种疼痛减轻的机制尚不清楚。本研究旨在探讨鞋内楔形矫形器对膝关节骨性关节炎患者下肢功能的影响。 总的来说，我们的目标是解决矫形器的即时效果，矫形器的长期效果，以及比较内侧和外侧楔形矫形器的即时和长期治疗效果。 该项目的组织分为三个目标： 目标1：确定鞋内楔形矫形器对膝关节OA受试者下肢对线力学和功能状态的即时影响。 目标二：确定鞋内楔形矫形器对膝关节骨关节炎受试者下肢对线、力学和功能状态的长期影响。 目标3：确定外侧与内侧鞋内楔形矫形器对内侧和外侧膝关节OA受试者下肢对线、力学和功能状态的不同影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In-shoe wedges have been shown to be an effective conservative approach in reducing pain in patients with osteoarthritis. The mechanism responsible for this pain reduction is not well understood. The goal of this project is to investigate the effect of in-shoe wedged orthoses on lower extremity function in patients with knee osteoarthritis. In general, our aims address the immediate effects of orthoses, the long-term effects of orthoses, and the immediate and long-term treatment effects comparing medial versus lateral wedged orthoses. The organization of this project has been divided into three aims: Aim 1: Determine the immediate effect of in-shoe wedged orthoses on lower extremity alignment mechanics and functional status in subjects with knee joint OA. Aim 2: Determine the long-term effect of in-shoe wedged orthoses on lower extremity alignment, mechanics, and functional status in subjects with knee joint osteoarthritis. Aim 3: Determine the differential effects of lateral versus medial in-shoe wedged orthoses on lower extremity alignment, mechanics, and functional status in subjects with medial and lateral knee joint OA.