MODEL FOR PARATHION DESULFURATION IN A LIVER SINUSOID

肝脏正弦波中对硫磷脱硫模型

• 批准号: 7381814
• 负责人: Seth F. Oppenheimer
• 金额: $ 3.72万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381814
• 关键词: MODEL; PARATHION; DESULFURATION; LIVER; SINUSOID

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Organophosphorus insecticides (OP) are one of the most widely used and important insecticide classes. After entering the mammalian blood stream, the OP will pass into the liver and from the portal vein to the central vein via sinusoids. While passing though the sinusoids some amount of the OP will enter the cell lining of the sinusoid and undergo desulfuration. It is this passage and the attendant desulfuration process that we intend to model. Furthermore, using data from our experimental collaborators, Shane Burgess and Janice Chambers, both of the College of Veterinary Medicine of Mississippi State University, we hope to use this model to perform simulations of this process. While we shall take a simplified approach to our modeling, ignoring several possibly important physical and chemical processes, we expect our work to give insights into the process of bioactivation within the liver. Furthermore, we shall carry out our work in such a manner as to allow greater generalization as we build toward an accurate and complete model of the mammalian liver and how it reacts to environmental toxins. Such a model will not only aid in the understanding of liver function vis-¿-vis the impact of OP contamination, but would be of great use in developing treatments for dangerous levels of exposure.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。有机磷杀虫剂（OP）是使用最广泛和最重要的杀虫剂类别之一。进入哺乳动物血流后，OP将通过正弦曲线进入肝脏，从门静脉进入中部静脉。尽管正弦曲线的一定程度将进入正弦曲线的细胞衬里并经过脱硫化。正是这段经文和随之而来的宣教合作者Shane Burgess和Janice Chambers是密西西比州立大学兽医学院，我们希望使用该模型对此过程进行模拟。尽管我们将采用简化的方法来进行建模，而忽略了几个可能的重要物理和化学过程，但我们希望我们的工作能够深入了解肝脏内生物活化过程。此外，我们将以一种方式进行工作，以便在我们建立朝着哺乳动物肝脏的准确而完整的模型及其对环境毒素的反应时进行更大的概括。这样的模型不仅将有助于理解OP污染的影响，而且在开发危险水平的治疗方法方面非常有用。