MODEL FOR PARATHION DESULFURATION IN A LIVER SINUSOID

肝脏正弦波中对硫磷脱硫模型

• 批准号: 7381814
• 负责人: Seth F. Oppenheimer
• 金额: $ 3.72万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381814
• 关键词: MODEL; PARATHION; DESULFURATION; LIVER; SINUSOID

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Organophosphorus insecticides (OP) are one of the most widely used and important insecticide classes. After entering the mammalian blood stream, the OP will pass into the liver and from the portal vein to the central vein via sinusoids. While passing though the sinusoids some amount of the OP will enter the cell lining of the sinusoid and undergo desulfuration. It is this passage and the attendant desulfuration process that we intend to model. Furthermore, using data from our experimental collaborators, Shane Burgess and Janice Chambers, both of the College of Veterinary Medicine of Mississippi State University, we hope to use this model to perform simulations of this process. While we shall take a simplified approach to our modeling, ignoring several possibly important physical and chemical processes, we expect our work to give insights into the process of bioactivation within the liver. Furthermore, we shall carry out our work in such a manner as to allow greater generalization as we build toward an accurate and complete model of the mammalian liver and how it reacts to environmental toxins. Such a model will not only aid in the understanding of liver function vis-¿-vis the impact of OP contamination, but would be of great use in developing treatments for dangerous levels of exposure.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。有机磷杀虫剂（OP）是最广泛使用和最重要的杀虫剂类别之一。 OP进入哺乳动物血流后，会进入肝脏，并通​​过血窦从门静脉到达中央静脉。当通过正弦曲线时，一些 OP 将进入正弦曲线的细胞内壁并进行脱硫。我们打算对这段通道和随之而来的脱硫过程进行建模。此外，利用来自密西西比州立大学兽医学院的实验合作者 Shane Burgess 和 Janice Chambers 的数据，我们希望使用该模型来模拟这一过程。 虽然我们将采用简化的方法进行建模，忽略几个可能重要的物理和化学过程，但我们希望我们的工作能够深入了解肝脏内的生物激活过程。此外，当我们建立哺乳动物肝脏及其对环境毒素如何反应的准确而完整的模型时，我们将以更加普遍化的方式开展我们的工作。这样的模型不仅有助于了解肝功能与有机磷污染的影响，而且对于开发针对危险暴露水平的治疗方法也有很大的用途。