MODEL FOR PARATHION DESULFURATION IN A LIVER SINUSOID

肝脏正弦波中对硫磷脱硫模型

• 批准号: 7381814
• 负责人: Seth F. Oppenheimer
• 金额: $ 3.72万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381814
• 关键词: MODEL; PARATHION; DESULFURATION; LIVER; SINUSOID

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Organophosphorus insecticides (OP) are one of the most widely used and important insecticide classes. After entering the mammalian blood stream, the OP will pass into the liver and from the portal vein to the central vein via sinusoids. While passing though the sinusoids some amount of the OP will enter the cell lining of the sinusoid and undergo desulfuration. It is this passage and the attendant desulfuration process that we intend to model. Furthermore, using data from our experimental collaborators, Shane Burgess and Janice Chambers, both of the College of Veterinary Medicine of Mississippi State University, we hope to use this model to perform simulations of this process. While we shall take a simplified approach to our modeling, ignoring several possibly important physical and chemical processes, we expect our work to give insights into the process of bioactivation within the liver. Furthermore, we shall carry out our work in such a manner as to allow greater generalization as we build toward an accurate and complete model of the mammalian liver and how it reacts to environmental toxins. Such a model will not only aid in the understanding of liver function vis-¿-vis the impact of OP contamination, but would be of great use in developing treatments for dangerous levels of exposure.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。有机磷杀虫剂（OP）是应用最广泛、最重要的杀虫剂类别之一。在进入哺乳动物血流后，OP将进入肝脏，并通过窦状隙从门静脉进入中央静脉。当通过窦状隙时，一定量的OP将进入窦状隙的细胞衬里并进行脱硫。我们打算模拟的正是这一通道和随之而来的脱硫过程。此外，利用我们的实验合作者Shane Burgess和Janice Chambers（均来自密西西比州立大学兽医学院）的数据，我们希望使用该模型来模拟这一过程。 虽然我们将采取简化的方法来建模，忽略几个可能重要的物理和化学过程，但我们希望我们的工作能够深入了解肝脏内的生物活化过程。此外，我们将以这样一种方式开展我们的工作，以便在我们建立哺乳动物肝脏的准确和完整模型以及它如何对环境毒素作出反应时，能够更好地进行推广。这样的模型不仅有助于维斯OP污染对肝功能的影响，而且在开发危险暴露水平的治疗方法方面也很有用。