NAPHTHALIMIDE-MODIFIED CHITOSAN MATERIALS TO CREATE BIODEGRADABLE FILMS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究项目涉及使用萘酰亚胺修饰的壳聚糖膜开发一种无缝线组织修复方法。这些薄膜是使用专有的交联光化学技术形成的。它们的使用，以及使用类似技术的相关粘合剂配方，可以提供一种新型的生物相容性，可生物降解的胶带，可用于在许多组织修复过程中替代缝合线。使用预先确定的组织模型，学生将评估化学和合成修饰如何改变薄膜的物理性质，如溶解度、拉伸强度和寿命。这些信息可以用来设计具有特定寿命的薄膜，以适应各种临床应用的需要。持久时间较长的膜可以设计用于实质性的组织缺陷或重建手术，而短时间的膜可以用于帮助修复轻微的组织缺陷

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project involves the development of a sutureless tissue repair method using naphthalimide-modified chitosan films. These films are formed using a proprietary crosslinking photochemical technology. Their use, along with a related adhesive formulation using similar technology, could provide a novel biocompatible, biodegradable tape that may be used to replace suture in a number of tissue repair procedures. Using a predetermined tissue model, the student would evaluate how chemical and synthetic modifications to the films alter physical properties such as solubility, tensile strength, and longevity. This information could then be used to design films with specific lifetimes suited to the needs of various clinical applications. Longer lasting films could be designed for use on substantial tissue defects or reconstructive surgery and short-lived films could be used to aid in the repair of minor