NAPHTHALIMIDE-MODIFIED CHITOSAN MATERIALS TO CREATE BIODEGRADABLE FILMS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究项目涉及开发一种使用萘酰亚胺修饰的壳聚糖膜的无缝合组织修复方法。这些薄膜是使用专有的交联光化学技术形成的。它们的使用，以及使用类似技术的相关粘合剂配方，可以提供一种新型的生物兼容、可生物降解的胶带，可用于在许多组织修复过程中取代缝合。使用预定的组织模型，学生将评估对薄膜的化学和合成修饰如何改变薄膜的物理性质，如溶解度、抗拉强度和寿命。这些信息然后可以用来设计具有特定寿命的薄膜，以适应各种临床应用的需要。可以设计更持久的薄膜用于实质性组织缺陷或重建手术，而短期薄膜可以用来帮助修复轻微伤口。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project involves the development of a sutureless tissue repair method using naphthalimide-modified chitosan films. These films are formed using a proprietary crosslinking photochemical technology. Their use, along with a related adhesive formulation using similar technology, could provide a novel biocompatible, biodegradable tape that may be used to replace suture in a number of tissue repair procedures. Using a predetermined tissue model, the student would evaluate how chemical and synthetic modifications to the films alter physical properties such as solubility, tensile strength, and longevity. This information could then be used to design films with specific lifetimes suited to the needs of various clinical applications. Longer lasting films could be designed for use on substantial tissue defects or reconstructive surgery and short-lived films could be used to aid in the repair of minor wounds.