COMPARING THE PROCESSES OF NEURAL DEVELOPMEANT & REGENERATION IN ZEBRAFISH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这个项目的目标是研究神经回路发育的机制，并将这些神经发育机制与斑马鱼的再生机制进行比较。这个项目的目的是确定神经再生是否类似于神经发育的过程，或者这两个过程是否代表不同的机制。这项工作的第一个具体目标是确定视网膜损伤后视网膜和顶盖的恢复是否遵循正常发育中发现的相同的解剖和生理序列。第二个具体目的是检查环境因素是否可以改变神经发育和再生的顺序。为了确定环境信号在视网膜发育和再生中的重要性，将改变维甲酸(RA)的水平；视黄酸是已知的视网膜发育所必需的形态原。该项目的意义在于，它将更好地了解神经再生和视觉发育之间的关系，并对眼睛健康问题和发生视网膜损伤的任何眼病都有影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to examine the mechanisms involved in the development of neural circuits and compare these mechanisms of neural development to the mechanisms involved in regeneration in zebrafish. The purpose of this project is to determine whether neural regeneration is similar to the process of neural development or whether the two processes represent different mechanisms. The first specific aim of this work is to determine whether the recovery of the retina and tectum following retinal damage follows the same anatomical and physiological sequence found in normal development. The second specific aim is to examine whether environmental factors can modify the sequence of neural development and regeneration. To determine the importance of environmental signals in the developing and regenerating retina, retinoic acid (RA) levels will be altered; RA is a known morphogen necessary for retinal development. The project's significance is that it will provide a better understanding of the relationship between neural regeneration and visual development and has implications for eye health issues and for any eye disease in which retinal damage occurs.