Arizona Clinical and Translational Science Award Planning Grant

描述（由申请人提供）：通过定义的临床和教育目标，独特的系统医学重点和全州致力于实施分子知情治疗决策计划的独特组合，亚利桑那州临床和转化科学奖将为临床和转化科学打造一个独特的变革，新颖和综合的学术家园。亚利桑那州目前的人口是整个美国的缩影：人口老龄化不断加剧，大量未参保的人口易患特定疾病，人口聚集但地理分散。我们建议组织我们的CTSA计划，使新的临床和转化计划，教育和职业发展计划将成功地解决这些复杂的健康问题。CTSA计划提供了一个逻辑框架，以整合巴特尔纪念研究所为亚利桑那州生物医学研究制定全州范围路线图的国家认可的努力，并利用亚利桑那州研究型生物医学和临床组织的研究和临床专业知识的互补优势，包括大学和研究机构，医院和医疗机构，NIDDK和IMS。一个大型的全州范围内的患者基础是一个巨大的资源，用于临床，转化和成果研究的应用，将从我们全州的临床研究工作。我们聚集了一批临床医生和科学家，他们代表了最高质量的临床护理和研究，对转化研究的持续承诺以及作为一个团队共同努力的明确承诺。亚利桑那州CTSA团队有具体的目标，它将解决，并将通过在应用，临床和结果研究的连续体工作，确保项目具有互补优势，将允许翻译和实施新的发现临床治疗和筛选程序。认识到我们团队的地理分布，我们已经开发了有效的通信方法，并将使用新一代技术，基于网络的多中心远程医疗，以加强在规划期间的沟通，使所有研究人员和机构都能为产生的联合研究工作做出重大贡献。CTSA代表了具有独特和显著合作记录的机构的综合努力，正式联手改善亚利桑那州和整个医学界患者的治疗结果。

DESCRIPTION (provided by applicant): Through the inimitable combination of defined clinical and educational goals, a unique systems-medicine focus and a statewide commitment to implement a program for molecularly-informed therapeutic decisions, the Arizona Clinical and Translational Science Award will forge a uniquely transformative, novel and integrative academic home for clinical and translational science. Arizona's current population is a microcosm of the US as a whole: a growing aging population, large uninsured populations with predisposition to specific diseases and a clustered but geographically-dispersed populous. We propose to organize our CTSA program so that novel clinical and translational programs and education and career development programs will successfully tackle these complex health problems. The CTSA program provides a logical framework to integrate nationally-recognized efforts by the Battelle Memorial Institute to develop a statewide roadmap for Arizona's biomedical research and capitalizes on the complementary strengths in research and clinical expertise of research-oriented biomedical and clinical organizations across Arizona, including universities and research institutes, hospitals and healthcare institutions, the NIDDK and the IMS. A large statewide patient base is a tremendous resource for application of clinical, translational and outcomes research that will derive from our statewide clinical research efforts. We have assembled a cadre of clinicians and scientists who represent highest quality clinical care and research, an ongoing commitment to translational research and an unequivocal commitment to work together as a team. The Arizona CTSA team has specific goals it will address and will do so by working across the continuum of applied, clinical, and outcomes research ensuring that projects have complementary strengths that will allow translation and implementation of new findings to clinical therapies and screening procedures. Recognizing the geographic dispersment of our team, we have developed effective methods of communication and will use new generation technology for web-based multi-center telemedicine to strengthen communication during the planning period so that all investigators and institutions can contribute significantly to the generated joint research efforts. The CTSA represents the integrated efforts of institutions with a unique and remarkably collaborative track record, formally joining forces to improve outcomes for patients across Arizona and the entire medical community.