Arizona Clinical and Translational Science Award Planning Grant

描述（由申请人提供）：通过明确的临床和教育目标的独特结合，独特的系统医学重点和全州范围内对实施分子信息治疗决策计划的承诺，亚利桑那州临床和转化科学奖将为临床和转化科学打造一个独特的变革，新颖和综合的学术家园。亚利桑那州目前的人口是整个美国的一个缩影：不断增长的老龄化人口，大量没有保险的人口易患特定疾病，人口聚集但地理上分散。我们建议组织我们的CTSA项目，以便新的临床和转化项目以及教育和职业发展项目能够成功地解决这些复杂的健康问题。CTSA计划提供了一个逻辑框架，整合了巴特尔纪念研究所在全国范围内认可的努力，为亚利桑那州的生物医学研究制定了一个全州范围的路线图，并利用了亚利桑那州研究型生物医学和临床组织在研究和临床专业知识方面的互补优势，包括大学和研究机构、医院和医疗机构、NIDDK和IMS。一个庞大的全州患者基础是临床应用的巨大资源，转化和结果研究将从我们的全州临床研究工作中获得。我们汇集了一批临床医生和科学家，他们代表着最高质量的临床护理和研究，对转化研究的持续承诺，以及作为一个团队共同努力的明确承诺。亚利桑那CTSA团队有具体的目标，他们将通过应用、临床和结果研究的连续工作来实现这一目标，确保项目具有互补的优势，从而将新发现转化和实施到临床治疗和筛查程序中。认识到我们团队的地理分散，我们已经开发了有效的沟通方法，并将在规划期间使用新一代基于网络的多中心远程医疗技术来加强沟通，以便所有研究人员和机构能够为产生的联合研究工作做出重大贡献。CTSA代表了具有独特和显著合作记录的机构的综合努力，正式联合起来改善亚利桑那州和整个医学界患者的结果。

DESCRIPTION (provided by applicant): Through the inimitable combination of defined clinical and educational goals, a unique systems-medicine focus and a statewide commitment to implement a program for molecularly-informed therapeutic decisions, the Arizona Clinical and Translational Science Award will forge a uniquely transformative, novel and integrative academic home for clinical and translational science. Arizona's current population is a microcosm of the US as a whole: a growing aging population, large uninsured populations with predisposition to specific diseases and a clustered but geographically-dispersed populous. We propose to organize our CTSA program so that novel clinical and translational programs and education and career development programs will successfully tackle these complex health problems. The CTSA program provides a logical framework to integrate nationally-recognized efforts by the Battelle Memorial Institute to develop a statewide roadmap for Arizona's biomedical research and capitalizes on the complementary strengths in research and clinical expertise of research-oriented biomedical and clinical organizations across Arizona, including universities and research institutes, hospitals and healthcare institutions, the NIDDK and the IMS. A large statewide patient base is a tremendous resource for application of clinical, translational and outcomes research that will derive from our statewide clinical research efforts. We have assembled a cadre of clinicians and scientists who represent highest quality clinical care and research, an ongoing commitment to translational research and an unequivocal commitment to work together as a team. The Arizona CTSA team has specific goals it will address and will do so by working across the continuum of applied, clinical, and outcomes research ensuring that projects have complementary strengths that will allow translation and implementation of new findings to clinical therapies and screening procedures. Recognizing the geographic dispersment of our team, we have developed effective methods of communication and will use new generation technology for web-based multi-center telemedicine to strengthen communication during the planning period so that all investigators and institutions can contribute significantly to the generated joint research efforts. The CTSA represents the integrated efforts of institutions with a unique and remarkably collaborative track record, formally joining forces to improve outcomes for patients across Arizona and the entire medical community.