Core--Informatics, Biostatistics and data management

核心--信息学、生物统计学和数据管理

• 批准号: 7052512
• 负责人: JEFFREY M. TRENT
• 金额: $ 41.76万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052512
• 关键词: bioinformatics; biomarker; biomedical equipment development; biomedical facility; biotechnology; bioterrorism /chemical warfare; computer data analysis; computer simulation; computer system design /evaluation; cooperative study; data management; experimental designs; functional /structural genomics; high throughput technology; metabolomics; radiation dosage; statistical service /center; statistics /biometry

This Core will provide a variety of informatics and biostatistical analytic support to the Research Projects, other Cores, and the Pilot Projects of the Center for High-Throughput Minimally-Invasive Radiation Biodosimetry. This Core will also provide central, secure hosting for data exchange among all Consortium members. As well as more specific bioinformatics issues described below, this Core will provide general statistical support in terms of experimental design, and statistical data analysis. This Core will also have a central role in the review of proposed Pilot Projects. Central members of the Core are Jeffrey Trent and Michael Bittner at TGen, and Marianthi Markatou at Columbia University, all of whom have international reputations in their field. Direct analytic efforts will center on informatics and specialized statistical support of efforts to develop biodosimeters based on gene expression in lymphocytes (Project 2) and small molecule production in body fluids (Project 3). In order for biomarkers to be useful as biodosimeters, it is important to be able to determine how accurately and effectively the marker measurements allow classification of irradiated individuals on the basis of the radiation doses they have sustained. To do this the Consortium will have to be able to rapidly find those markers that not only separate the classes, but those which do so with the greatest resistance to inter-individual variation and assay noise. The Consortium will also benefit from a clear understanding of the ways in which the fundamental mechanisms of cellular response to radiation give rise to the measurable outcomes in the various assays proposed. In concert with the functional genomics Core and also with Project 3, this Core will analyze functional genomic and metabolomic measurements from the responding cells in most of these assays. This will allow assessments of the common and differential aspects of the genomic/metabolomic response in the various systems, and help us discern where the measurements provide complementary or redundant information. In summary, this Core will provide the bioinformatics that will be crucial to the success of Projects 2 and 3, and will provide statistical support in terms of experimental design and data analysis for all Consortium members.

该核心将为研究项目、其他核心和高通量微创辐射生物剂量学中心的试点项目提供各种信息学和生物统计分析支持。该核心还将为所有联合会成员之间的数据交换提供中央安全托管服务。除了下文描述的更具体的生物信息学问题外，该核心还将提供实验设计和统计数据分析方面的一般统计支持。该核心还将在审查拟议的试点项目方面发挥核心作用。核心的核心成员是TGen的Jeffrey Trent和Michael Bittner，以及哥伦比亚大学的Marianthi Markatou，他们都在各自的领域享有国际声誉。直接的分析工作将集中在信息学和专门的统计支持，努力开发基于淋巴细胞基因表达（项目2）和体液中小分子生产（项目3）的生物剂量计。为了使生物标记物可用作生物剂量计，重要的是能够确定标记物测量的准确性和有效性如何，从而能够根据受辐射个体所承受的辐射剂量对其进行分类。要做到这一点，联盟将必须能够迅速找到那些标记，不仅分离类，但那些这样做的最大阻力，个体间的变化和测定噪音。该联合会还将受益于清楚地了解细胞对辐射反应的基本机制如何在所提议的各种测定中产生可测量的结果。与功能基因组学核心和项目3相一致，该核心将分析大多数这些测定中响应细胞的功能基因组学和代谢组学测量。这将允许评估不同系统中基因组/代谢组学响应的共同和差异方面，并帮助我们辨别测量结果 提供补充或冗余信息。总之，该核心将提供对项目2和3的成功至关重要的生物信息学，并将为所有联盟成员提供实验设计和数据分析方面的统计支持。