CTSA Planning at Dartmouth Medical School

描述（由申请人提供）：成像、基因组学、蛋白质组学和其他生物医学技术的最新进展极大地增强了我们对健康和疾病的理解。然而，如果我们要实现我们的知识所允许的医疗保健改善的承诺，我们必须重新配置以研究为基础的机构，以强调临床和转化研究的综合，多学科方法。达特茅斯医学院的研究人员已经开始转变他们的临床和转化研究方法。与RFA RM-06-011的目标一致，题为“机构科学奖（CTSA）的规划赠款"，我们寻求启动一个规划过程，在达特茅斯设计一个CTSA。这一规划过程将利用我们最近的成就，并导致我们的行政结构，我们的教育计划和我们的研究活动的重新设计，以优化临床和转化科学在达特茅斯。我们将集中精力：阐明疾病的病理生理学;开发新的干预措施和创新的临床试验方法;评估临床实践中的干预措施;并确保临床和转化科学对健康和医疗保健服务的最大影响。通过规划过程，我们将优化利用现有资源，确定组织，教育和研究需求，并致力于建立达特茅斯作为临床和转化科学的主要国家网站。 我们的具体目标是这个规划补助金是：（1）组织一个严格的，多层次的规划过程，以创建合作伙伴关系，组织结构和资源，以改变我们的教学方式，进行和整合临床和转化研究在达特茅斯;和（2）准备，在这个规划过程结束时提交申请到美国国立卫生研究院一个成熟的达特茅斯CTSA。

DESCRIPTION (provided by applicant): Recent advances in imaging, genomics, proteomics, and in other biomedical technologies have greatly enhanced our understanding of health and disease. If we are to meet the promise of improvements in health care that our knowledge allows, however, we must reconfigure research-based institutions to emphasize an integrated, multi-disciplinary approach to clinical and translational research. Investigators at Dartmouth Medical School have begun to transform their approach to clinical and translational research. Inline with the goals of the RFA RM-06-011, entitled "Planning Grants for Institutional Science Awards (CTSA)", we seek to initiate a planning process to design a CTSA at Dartmouth. This planning process will capitalize on our recent accomplishments and lead toward a re-engineering of our administrative structures, our educational programs, and our research activities in order to optimize clinical and translational science at Dartmouth. We will focus our efforts toward: elucidating disease pathophysiology; developing novel interventions and innovative approaches to clinical trials; evaluating interventions in clinical practice; and assuring maximum impact of clinical and translational science on health and health care delivery. Through the planning process, we will optimize utilization of current resources, define organizational, educational, and research needs, and work toward establishing Dartmouth as a major national site for clinical and translational science. Our Specific Aims for this planning grant are: (1) to organize a rigorous, multi-level planning process to create the partnerships, organizational structure, and resources to transform the way we teach, conduct and integrate clinical and translational research at Dartmouth; and (2) to be prepared, by the end of this planning process to submit an application to the NIH for a mature Dartmouth CTSA.