INFLUENCE OF BEHAVIORAL EXPERIENCE ON NEURAL PLASTICITY IN STROKE NEUROREHAB

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。Jones和Schallert在这个项目中的主要任务是：(a)设计和实施一个带有控制程序的运动康复计划，以增强感觉运动皮层单侧局局性缺血性损伤的大鼠的神经和功能结果；(b)在UT进行功能结果的视频测量分析，包括前肢伸展和感觉运动功能；(c)对McNeill实验室的人员和南加州大学的其他人员进行康复训练和功能结果测试培训；(d)制备实验大鼠脑送McNeill进行分子变化分析(e)评估双半球新皮层神经元结构变化，包括锥体神经元树突树突和脊柱在UT和USC实验动物脑中的变化；(f)通过频繁前往南加州大学并通过电子邮件通信参与实验的执行，以检查运动疗法和增强或降低缺血性损伤大鼠和人的神经可塑性的药物的相互作用。主要关注的问题是：(1)与单独操作相比，杂技体验和伸臂训练相结合是否能显著改善行为结果；(2)对改善行为功能最优的康复训练操作是否能促进最大的皮层和纹状体神经可塑性改变

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary tasks of Jones and Schallert in this project are to: (a) design and implement a motor rehabilitation program with control procedures to enhance neural and functional outcome in rats that sustain focal ischemic injury unilaterally in the sensorimotor cortex; (b) carry out at UT a videometric analysis of functional outcome, including forelimb reaching and sensorimotor function; (c) train personnel in the McNeill lab and others at USC on rehabilitative training and functional outcome tests; (d) prepare the brains of experimental rats to be sent to McNeill for analyses of molecular changes (e) assess bi-hemispheric neocortical neuronal structural changes, including pyramidal neuron dendritic arborization and spine changes in the brains of experimental animals from both UT and USC; (f) participate by frequent trips to USC and email correspondence in the execution of experiments examining the interactive effects of motor therapy and agents that enhance or reduce neuroplasticity in both rats and people with ischemic injury. The questions of primary interests are (1) whether the combination of acrobatic experience and reach training will significantly improve behavioral outcome compared to either independent manipulation and (2) whether the rehabilitative training manipulation that is optimal for improving behavioral function promotes the greatest cortical and striatal neuroplastic change