CHARACTERIZATION OF LUNG SURFACTANT LIPID DEGRADATION IN PSEUDOMONAS AERUGINOSA

铜绿假单胞菌肺表面活性剂脂质降解的表征

• 批准号: 7381989
• 负责人: Tung T Hoang
• 金额: $ 6.71万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381989
• 关键词: CHARACTERIZATION; LUNG; SURFACTANT; LIPID; DEGRADATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pseudomonas aeruginosa, an opportunistic pathogen which causes life-threatening infections in wounds, burns and in particular the lung of cystic fibrosis patients, is a bacterium which is extremely difficult to eradicate with antibiotics due to resistance mechanisms and biofilm formation. The pathogenesis of P. aeruginosa lung infection in cystic fibrosis patients is not clear. A better understanding of the pathogenesis and mechanisms of growth of P. aeruginosa in the lung may lead to identification of new ways to eradicate the organism in these chronic lung infections.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。铜绿假单胞菌（Pseudomonasaeruginosa）是一种机会致病菌，其在伤口、烧伤和特别是囊性纤维化患者的肺中引起危及生命的感染，是一种由于耐药性机制和生物膜形成而极难用抗生素根除的细菌。囊性纤维化患者铜绿假单胞菌肺部感染的发病机制尚不清楚。更好地了解铜绿假单胞菌在肺中生长的发病机制和机制可能会导致确定新的方法来根除这些慢性肺部感染中的有机体。