CHARACTERIZATION OF LUNG SURFACTANT LIPID DEGRADATION IN PSEUDOMONAS AERUGINOSA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pseudomonas aeruginosa, an opportunistic pathogen which causes life-threatening infections in wounds, burns and in particular the lung of cystic fibrosis patients, is a bacterium which is extremely difficult to eradicate with antibiotics due to resistance mechanisms and biofilm formation. The pathogenesis of P. aeruginosa lung infection in cystic fibrosis patients is not clear. A better understanding of the pathogenesis and mechanisms of growth of P. aeruginosa in the lung may lead to identification of new ways to eradicate the organism in these chronic lung infections.