A Study of Water-Spread Polymer Micelles on Water Surface: Toward Developing a First-in-Kind Polymer Lung Surfactant Therapy
水面上水铺展聚合物胶束的研究:开发首创聚合物肺表面活性剂疗法
基本信息
- 批准号:2211843
- 负责人:
- 金额:$ 40.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Every year around 200,000 patients in the US are diagnosed with Acute Respiratory Distress Syndrome (ARDS) as a result of such causes as viral infection (e.g., COVID-19), physical trauma, and inhalation of chemicals. Patients diagnosed with ARDS (critically low blood oxygenation levels) face a staggering 40% mortality rate. The use of animal-derived lung surfactant replacement therapy that has been used to treat certain respiratory conditions has not been successful in treating ARDS. Therefore, there is dire need for an effective therapeutic that goes beyond current treatments (mechanical ventilation). The investigator’s laboratory is pioneering a transformative first-in-kind “Polymer Lung Surfactant (PLS)” therapy that is composed of a block copolymer and can address limitations of conventional animal-derived lung surfactant therapeutics. By studying their fundamental behavior, advances can be made in the development of a PLS with the hope of ultimately translating this research to improvements in human health outcomes.Lung surfactant replacement therapy is one of the greatest achievements in interfacial science research. Each year in the US alone, this lung surfactant technology saves over 30,000 newborns suffering from deficiency of endogenous lung surfactant. Adults can suffer from similar symptoms (ARDS) when the function of their native lung surfactant becomes impaired due to injury to lung parenchyma. Unfortunately, the surfactant replacement therapy which is used to treat neonates with insufficient lung surfactant stores has not been shown to be effective for ARDS. It has been discovered that micelles derived from a synthetic amphiphilic block copolymer, poly(styrene)-poly(ethylene glycol) (PS-PEG), show great promise for the treatment of ARDS. A greater understanding of the fundamental science of the interfacial mechanical and transport behavior of water-spread block copolymers is required for further advancement of this technology. This is the gap that this award aims to fill. Specifically, the experiments provide understanding on the molecular origin of the unique surface mechanical behavior of water-spread PS-PEG micelles on water surface (toward further optimization of PLS formulations). Surface rheological behavior of water-spread PS-PEG micelles (to understand their unique protein resistant behavior) will be studied. Interfacial flow and coating properties of PS-PEG micelle solutions through lung airways (which will help optimize PLS delivery processes) will be investigated. This award provides multidisciplinary training for graduate and undergraduate students involved to learn state-of-the-art concepts and skills in interfacial engineering. Available campus resources are used to enhance recruitment of underrepresented/minority undergraduate students for this project. Local high school students are provided with research experience opportunities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在美国,每年约有20万患者被诊断为急性呼吸窘迫综合征(ARDS),其原因是病毒感染(例如,COVID-19)、身体创伤和吸入化学品。被诊断患有ARDS(严重低血氧水平)的患者面临着惊人的40%的死亡率。动物源性肺表面活性物质替代疗法已用于治疗某些呼吸系统疾病,但在治疗ARDS方面并不成功。因此,迫切需要一种超越当前治疗(机械通气)的有效治疗方法。研究人员的实验室正在开创一种变革性的第一种“聚合物肺表面活性剂(PLS)”疗法,该疗法由嵌段共聚物组成,可以解决传统动物源性肺表面活性剂疗法的局限性。通过研究它们的基本行为,可以在PLS的发展中取得进展,并希望最终将这项研究转化为人类健康结果的改善。肺表面活性物质替代疗法是界面科学研究中最伟大的成就之一。每年仅在美国,这种肺表面活性剂技术就挽救了30,000多名患有内源性肺表面活性剂缺乏症的新生儿。当由于肺实质损伤而导致其天然肺表面活性物质的功能受损时,成人可遭受类似的症状(ARDS)。不幸的是,用于治疗肺表面活性物质储存不足的新生儿的表面活性物质替代疗法尚未显示对ARDS有效。已经发现,衍生自合成的两亲性嵌段共聚物聚(苯乙烯)-聚(乙二醇)(PS-PEG)的胶束显示出治疗ARDS的巨大前景。为了进一步发展这一技术,需要对水分散嵌段共聚物的界面机械和传输行为的基础科学有更深入的了解。这就是这个奖项旨在填补的差距。具体而言,实验提供了对水分散PS-PEG胶束在水表面上的独特表面机械行为的分子起源的理解(朝向PLS制剂的进一步优化)。将研究水分散PS-PEG胶束的表面流变行为(以了解其独特的蛋白质抗性行为)。将研究PS-PEG胶束溶液通过肺气道的界面流动和涂层性质(这将有助于优化PLS递送过程)。该奖项为研究生和本科生提供多学科培训,以学习界面工程中最先进的概念和技能。可用的校园资源被用来加强代表性不足/少数民族本科生为这个项目的招聘。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Radiation-induced photodynamic therapy using calcium tungstate nanoparticles and 5-aminolevulinic acid prodrug
- DOI:10.1039/d3bm00921a
- 发表时间:2023-08-02
- 期刊:
- 影响因子:6.6
- 作者:Viswanath,Dhushyanth;Shin,Sung-Ho;Won,You-Yeon
- 通讯作者:Won,You-Yeon
Surface Pressure-Area Mechanics of Water-Spread Block Copolymer Micelle Monolayers at the Air-Water Interface: Effect of Hydrophobic Block Chemistry
空气-水界面处水铺展嵌段共聚物胶束单层的表面压力面积力学:疏水嵌段化学的影响
- DOI:
- 发表时间:2023
- 期刊:
- 影响因子:3.9
- 作者:Kim, Seyoung;Park, Sungwan;Fesenmeier, Daniel J.;Jun, Taesuk;Sarkar, Kaustabh;Won, You-Yeon
- 通讯作者:Won, You-Yeon
Determination of Glass Transition Temperatures in Bulk and Micellar Nanoconfined Polymers Using Fluorescent Molecular Rotors as Probes for Changes in Free Volume
- DOI:10.1021/acs.macromol.3c00968
- 发表时间:2023-08-01
- 期刊:
- 影响因子:5.5
- 作者:Kim, Seyoung;Lee, Minhwan;Won, You-Yeon
- 通讯作者:Won, You-Yeon
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You-Yeon Won其他文献
Fast response humidity sensor based on graphene oxide films supported by TiO2 nanorods
基于TiO2纳米棒支撑氧化石墨烯薄膜的快速响应湿度传感器
- DOI:
10.1016/j.diamond.2020.108031 - 发表时间:
2020-11 - 期刊:
- 影响因子:4.1
- 作者:
Xuan Zhao;Xiangdong Chen;You-Yeon Won;Xing Ding;You-Yeon Won;Xiangdong Chen - 通讯作者:
Xiangdong Chen
Imaging nanostructured fluids using cryo-TEM
- DOI:
10.1007/bf02705412 - 发表时间:
2004 - 期刊:
- 影响因子:2.7
- 作者:
You-Yeon Won - 通讯作者:
You-Yeon Won
You-Yeon Won的其他文献
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{{ truncateString('You-Yeon Won', 18)}}的其他基金
Statistically Sequence-Controlled Pharmaceutical Polymers, and Studies of Their Molecular Thermodynamic and Kinetic Properties
统计序列控制的药用聚合物及其分子热力学和动力学性质的研究
- 批准号:
1803968 - 财政年份:2018
- 资助金额:
$ 40.34万 - 项目类别:
Standard Grant
I-Corps: Polymer Lung Surfactants for Neonatal Respiratory Distress Syndrome
I-Corps:聚合物肺表面活性剂治疗新生儿呼吸窘迫综合征
- 批准号:
1713953 - 财政年份:2017
- 资助金额:
$ 40.34万 - 项目类别:
Standard Grant
A Study of the Air-Water Interfacial Behavior of Biodegradable Polyesters: Toward Rational Design of a Polymeric Lung Surfactant
可生物降解聚酯的空气-水界面行为研究:合理设计聚合物肺表面活性剂
- 批准号:
1264336 - 财政年份:2013
- 资助金额:
$ 40.34万 - 项目类别:
Standard Grant
Novel Mixed Brushes with Tunable Internal Structures of Various Length Scales
具有各种长度尺度可调内部结构的新型混合刷
- 批准号:
0906567 - 财政年份:2009
- 资助金额:
$ 40.34万 - 项目类别:
Standard Grant
Identification of the Polycation Molecular Factors That Promote the Intracellular Trafficking of Polycation/DNA Complexes
促进聚阳离子/DNA 复合物细胞内运输的聚阳离子分子因子的鉴定
- 批准号:
0828574 - 财政年份:2008
- 资助金额:
$ 40.34万 - 项目类别:
Standard Grant
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