COBRE: OUHSC: PROTEOMICS/BIOINFORMATICS CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。机构发展奖（IDEA）计划的目的是促进与健康相关的研究，并通过支持教师发展和加强研究机构的基础设施来提高研究人员的竞争力，这些机构位于历史上获得NIH资助的总成功率较低的州。因此，我们建立了一个以视觉和眼科研究为主题的生物医学研究卓越中心（COBRE）。COBRE及其核心设施由美国国立卫生研究院资助的研究人员领导，包括五名没有NIH R01支持历史的年轻研究人员。Matsumoto博士在二维凝胶电泳，质谱分析和蛋白质组学数据分析方面拥有专业知识，指导眼部蛋白质组学/生物信息学核心。2002年2月人类基因组草图的完成有力地预示了生物医学科学的未来。没有基因组数据的有效利用，任何领域的生物医学科学都将遭受缓慢的进展。在此背景下，蛋白质组学/生物信息学核心协助所有参与的视觉研究人员在眼部蛋白质组学方面提供相关技术和科学指导。COBRE蛋白质组学/生物信息学核心以现有的P30国家眼科研究所视觉研究分析生物化学核心设施为基础，具备二维凝胶电泳、图像存档和分析、凝胶内消化、多肽质量指纹图谱识别目标蛋白、通过分析多个二维凝胶数据进行数据挖掘、基因组数据库和通过互联网搜索相关生物信息的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Institutional Development Award (IDEA) program is to foster health-related research and to increase the competitiveness of investigators through support of faculty development and enhancement of the research infrastructure of institutions located in states with historically low aggregate success rates for grant awards from the NIH. Thus, we established a Center of Biomedical Research Excellence (COBRE) with the thematic focus of Vision and Ophthalmologic Research. The COBRE and its Core Facilities are headed by established NIH-funded investigators and includes five young investigators who do not have a prior history of NIH R01 support. Dr. Matsumoto who has expertise in two-dimensional gel electrophresis, mass spectrometry, and the analyses of proteomics data directs the Ocular Proteomics/Bioinformatics Core. The completion of the draft of human genome in February 2002 eloquently predicts the future of biomedical sciences. Without an efficient use of genome data the biomedical sciences in any area will suffer from slow progress. Upon this background, the Proteomics/Bioinformatics Core assists all of the participating vision researchers with the pertinent techniques and scientific guidance in ocular proteomics. The COBRE Proteomics/Bioinformatics Core is based on the existing P30 National Eye Institute Vision Research Analytical Biochemistry Core Facility and renders the capability of running two-dimensional gel electrophoresis, image archiving and analysis, in-gel digestion, peptide mass fingerprinting for the identification of target proteins, datamining through the analysis of multiple two-dimensional gel data, and genome database and relevant bioinformation searches through the Internet.