COBRE: OUHSC: PROTEOMICS/BIOINFORMATICS CORE

COBRE：OUHSC：蛋白质组学/生物信息学核心

• 批准号: 7610502
• 负责人: HIROYUKI MATSUMOTO
• 金额: $ 10.09万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610502
• 关键词: Analytical Biochemistry; Archives; Area; Award; Bioinformatics; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Digestion; Faculty; Fingerprint; Fostering; Funding; Future; Gel; Genome; Grant; Head; Human Genome; Image; Institution; Internet; Mass Spectrum Analysis; National Eye Institute; Peptides; Proteins; Proteomics; Purpose; Rate; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resources; Running; Science; Source; Techniques; Two-Dimensional Gel Electrophoresis; United States National Institutes of Health; Vision; Vision research; base; data mining; genome database; programs; ranpirnase; success; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Institutional Development Award (IDEA) program is to foster health-related research and to increase the competitiveness of investigators through support of faculty development and enhancement of the research infrastructure of institutions located in states with historically low aggregate success rates for grant awards from the NIH. Thus, we established a Center of Biomedical Research Excellence (COBRE) with the thematic focus of Vision and Ophthalmologic Research. The COBRE and its Core Facilities are headed by established NIH-funded investigators and includes five young investigators who do not have a prior history of NIH R01 support. Dr. Matsumoto who has expertise in two-dimensional gel electrophresis, mass spectrometry, and the analyses of proteomics data directs the Ocular Proteomics/Bioinformatics Core. The completion of the draft of human genome in February 2002 eloquently predicts the future of biomedical sciences. Without an efficient use of genome data the biomedical sciences in any area will suffer from slow progress. Upon this background, the Proteomics/Bioinformatics Core assists all of the participating vision researchers with the pertinent techniques and scientific guidance in ocular proteomics. The COBRE Proteomics/Bioinformatics Core is based on the existing P30 National Eye Institute Vision Research Analytical Biochemistry Core Facility and renders the capability of running two-dimensional gel electrophoresis, image archiving and analysis, in-gel digestion, peptide mass fingerprinting for the identification of target proteins, datamining through the analysis of multiple two-dimensional gel data, and genome database and relevant bioinformation searches through the Internet.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 机构发展奖 (IDEA) 计划的目的是促进与健康相关的研究，并通过支持教师发展和加强位于 NIH 拨款总成功率历史较低的州的机构的研究基础设施来提高研究人员的竞争力。因此，我们建立了生物医学卓越研究中心 (COBRE)，其主题重点是视觉和眼科研究。 COBRE 及其核心设施由 NIH 资助的资深研究人员领导，其中包括五名没有 NIH R01 支持历史的年轻研究人员。 Matsumoto 博士在二维凝胶电泳、质谱和蛋白质组数据分析方面拥有丰富的专业知识，负责指导眼部蛋白质组/生物信息学核心。 2002 年 2 月人类基因组草图的完成雄辩地预测了生物医学的未来。如果没有有效利用基因组数据，任何领域的生物医学科学都将进展缓慢。在此背景下，蛋白质组学/生物信息学核心为所有参与的视觉研究人员提供眼部蛋白质组学的相关技术和科学指导。 COBRE蛋白质组学/生物信息学核心基于现有的P30国家眼科研究所视觉研究分析生物化学核心设施，具有运行二维凝胶电泳、图像存档和分析、凝胶内消化、用于识别目标蛋白的肽质量指纹、通过分析多个二维凝胶数据进行数据挖掘、基因组数据库和相关功能的能力。 通过互联网搜索生物信息。