COBRE: LSU HSC: ADMINISTRATIVE CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。行政核心设在药理学系，支持该方案的全面管理。行政核心为方案的有效运作提供了保护伞。项目主任史蒂芬·M·拉尼尔博士负责项目的所有行政方面，并监督指导工作。Lynnette Small担任Cobre赠款的行政协调员，并与药理学部门业务经理Karen Jorgenson密切合作。斯莫尔女士建立了一个卓越的办公室，负责处理Cobre行政核心的所有财务、采购和组织问题。她每月与初级调查人员和核心主任会面，每周与项目主任拉尼尔博士会面。史莫尔女士亦与部门人事总监林明训先生紧密合作，引进新员工。三名老牌教员加入我们，成为科布雷的新导师。Parthasarathy博士从埃默里大学加入我们，Lucchesi博士从阿拉巴马大学伯明翰分校加入我们。Kapusta博士是药理学系的教授，拥有两笔R01奖学金，重点是阿片肽在控制心血管和肾功能方面的作用。Lucchesi博士和Parthasarathy博士得到了来自NIH的多笔赠款的良好资助，并在血管生物学和/或心肌肥厚领域开展工作。项目、主任和导师如下：项目1-PARP1和血管中的氧化应激JI：Hamid A.Boulares，博士导师：SamPath Parthasarathy，博士。项目2-基因转移，氧化应激和糖尿病血管疾病项目主任/导师：Frank Park，博士导师：Daniel R.Kapusta，博士。项目3-VSMC中生长因子和整合素信号的整合：安德鲁·D·卡特林，博士导师：Pamela A.Lucchesi，博士项目4-内质网到高尔基体心肌细胞中信号蛋白的运输和VSMC项目主任/导师JI：光宇，博士。导师：William Claycomb，博士和Stephen M.Lanier，博士。项目5--一氧化氮缺乏项目中的血管平滑肌可塑性：Gregory M.Dick，博士导师：William M.Chilian，博士和Daniel R.Kapusta，博士。项目6--炎症在内皮再灌注损伤中的作用项目主任/导师：张翠华，博士行政支助小组协助制定了2005年3月提交的两份共享仪器设备补助金，以及2004年9月提交的国立卫生研究院机构博士前培训补助金，用于“综合药理学和生理学培训”。这些举措将直接使心血管生物学领域的发展项目受益。NIH/NCRR与IBM电子服务器计算机共享仪器拨款“Thermo Finnigan Proteome X LTQ Workstation(LC/MS)”PI：art L.Haas，Ph.D.项目期：04/01/2006-03/31/2007提交的总成本：496,150美元提交的：2005年3月21日NIH/NCRR共享仪器赠款“在活体电子顺磁共振成像系统(Bruker Elesys)中”PI：Barry Potter，Ph.D.项目期：04/01/2006-03/31/2007提交的总成本：482,170美元2005年NIH/NIGMS博士前培训补助金“综合药理学和生理学培训”PI：Stephen M.Lanier博士项目期间：2005年7月1日至2010年6月30日总成本：865,353美元行政核心还为LSUHSC心血管卓越中心和Cobre计划“心血管生物学导师”建立了网站。Http://www.medschool.lsuhsc.edu/cardio_center/http://www.medschool.在接下来的一年里，我们将继续为初级调查人员的资助发展提供支持，为共享仪器奖提供资助，并为基础设施建设和动物护理设施的升级提供资助。这一核心运行良好，预计来年不会有任何变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The administrative core is based in the Department of Pharmacology and supports the overall management of the program. The administrative core provides the umbrella for effective operation of the program. The Program Director, Stephen M. Lanier, Ph.D. is responsible for all administrative aspects of the program and oversight of the mentoring effort. Lynnette Small serves as Administrative Coordinator for the COBRE grant and works very closely with the Department of Pharmacology Business Manager, Karen Jorgenson. Ms. Small has established a superb office that handles all fiscal, purchasing, and organizational issues for the COBRE administrative core. She meets monthly with each of the Junior Investigators and Core Directors and weekly with the Program Director, Dr. Lanier. Ms. Small has also worked very closely with our departmental Personnel Director, Mr. Paul Lam, to bring on new staff. Three established faculty joined us as new mentors on the COBRE. Dr. Parthasarathy joined us from Emory University and Dr. Lucchesi joined us from the University of Alabama - Birmingham. Dr. Kapusta is a Professor in the Department of Pharmacology with two R01 grants focused on the role of opioid peptides on control of cardiovascular and renal function. Drs. Lucchesi and Parthasarathy are well funded by multiple grants from NIH and work in the area of vascular biology and/or cardiac hypertrophy. Projects, Directors and Mentors are listed below: Project 1 - PARP1 and Oxidant Stress in the Vasculature Project Director/Mentored JI: Hamid A. Boulares, Ph.D. Mentor: Sampath Parthasarathy, Ph.D. Project 2 - Gene Transfer, Oxidant Stress, and Diabetic Vascular Disease Project Director/Mentored JI: Frank Park, Ph.D. Mentor: Daniel R. Kapusta, Ph.D. Project 3 - Integration of Growth Factors and Integrin Signaling in VSMC Project Director/Mentored JI: Andrew D. Catling, Ph.D. Mentor: Pamela A. Lucchesi, Ph.D. Project 4 - ER to GOLGI Trafficking of Signaling Proteins in Cardiac Myocytes and VSMC Project Director/Mentored JI: Guangyu Wu, Ph.D. Mentors: William Claycomb, Ph.D. and Stephen M. Lanier, Ph.D. Project 5 - Vascular smooth muscle plasticity in nitric oxide deficiency Project Director/Mentored JI: Gregory M. Dick, Ph.D. Mentors: William M. Chilian, Ph.D. and Daniel R. Kapusta, Ph.D. Project 6 - Role of Inflammation in Endothelial Reperfusion Injury Project Director/Mentored JI: Cuihua Zhang, Ph.D. Mentor: William M. Chilian, Ph.D. The administrative support team assisted in the development of two shared instrumentation grants submitted in March 2005, as well as an NIH institutional predoctoral training grant, submitted in September 2004, for "Training in Integrative Pharmacological and Physiological Sciences". These initiatives will directly benefit the developing program in cardiovascular biology. NIH/NCRR Shared Instrumentation Grant "Thermo Finnigan Proteome X LTQ Workstation (LC/MS) with IBM e-server computer" PI: Art L. Haas, Ph.D. Project Period: 04/01/2006 - 03/31/2007 Total Cost: $496,150 Submitted: March 21, 2005 NIH/NCRR Shared Instrumentation Grant "In Vivo Electron Paramagnetic Resonance Imaging System (Bruker Elesys)" PI: Barry Potter, Ph.D. Project Period: 04/01/2006 - 03/31/2007 Total Cost: $482,170 Submitted: March 21, 2005 NIH/NIGMS Predoctoral Training Grant "Training in Integrative Pharmacological and Physiological Sciences" PI: Stephen M. Lanier, Ph.D. Project Period: 07/01/2005 to 06/30/2010 Total Costs: $865,353 The administrative core also established the WEB site for the LSUHSC Cardiovascular Center of Excellence and for the COBRE program "Mentoring in Cardiovascular Biology". http://www.medschool.lsuhsc.edu/cardio_center/ http://www.medschool. suhsc.edu/cardio_center/COBRE.asp In the upcoming year, we will be providing continued support for grant development by Junior Investigators, Shared Instrumentation Awards and grants for infrastructure development and upgrade of animal care facilities. This core is functioning fine and no changes are anticipated in the upcoming year.