Mood and Anxiety Subtypes in Anorexia Nervosa: Relevance to Treatment

神经性厌食症的情绪和焦虑亚型：与治疗的相关性

• 批准号: 7383648
• 负责人: JENNIFER E WILDES
• 金额: $ 13万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7383648
• 关键词: Acute; Admission activity; Affect; Anorexia Nervosa; Anxiety; Anxiety Disorders; Binge Eating; Body Weight decreased; Caring; Classification; Clinical; Complex; DSM-IV; Data; Development; Disease; Disinhibition; Eating Disorders; Etiology; Goals; Heterogeneity; Individual; Inpatients; Intervention; Lead; Length of Stay; Manic; Measures; Mental Health; Mentored Research Scientist Development Award; Mentors; Modeling; Moods; Morbidity - disease rate; Outcome; Participant; Patients; Pattern; Personality Traits; Population; Prevention program; Psychopathology; Qualifying; Quality of life; Recording of previous events; Recurrence; Relapse; Relative (related person); Reporting; Research; Research Personnel; Research Training; Scheme; Severities; Short-Term Course; Social Phobia; Structure; Subgroup; Symptoms; Techniques; Temperament; Time; Training; Week; Weight; base; career; clinically relevant; depressive symptoms; design; medical specialties; novel; outcome forecast; programs; psychosocial; purge; response; restoration; therapy development; two-dimensional

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award application describes training and research plans designed to qualify the candidate for a career as an independent mental health researcher with expertise in the implications of co-morbid psychopathology for the etiology, classification and treatment of eating disorders. Unrecognized systematic heterogeneity within the population of individuals with eating disorders may produce inconsistent findings across studies (e.g., if heterogeneous subgroups are entered in different proportions in different studies) and obscure clinically relevant information about etiology, prognosis and treatment response. In this application, the research plan focuses on understanding how heterogeneity in patterns of co-morbid mood and anxiety psychopathology is related to treatment response in patients with anorexia nervosa (AN). To this end, the underlying structure of mood and anxiety disorder co-morbidity will be examined in 150 AN patients using dimensional measures of psychiatric symptomatology and temperament. Participants will be assessed 1-2 weeks after admission for acute (i.e., inpatient or day hospital) treatment at a large, well established specialty care program and then followed closely for 12 months after discharge to determine whether co-morbidity subtypes have utility for identifying predictors of treatment response in AN. Guided by an interdisciplinary team of mentors, advanced training in 1) clinical and etiologic factors relevant to research with AN patients; 2) dimensional approaches to the study of psychopathology; and 3) data analytic techniques for identifying clinical subgroups and modeling longitudinal outcomes will facilitate the candidate's goal of establishing an independent research career focusing on the psychopathology and treatment of AN. Information about differences among AN patients with respect to mood and anxiety disorder symptoms and personality traits will promote treatment development initiatives by identifying potential targets for novel interventions. Further, a better understanding of factors related to negative outcome during the period immediately following discharge from acute treatment may lead to the development of more effective treatments and relapse prevention programs. Finally, understanding robust differences in symptom patterns among patients with AN may provide clues that will promote research on the complex causes of this pernicious disorder.

描述（由申请人提供）：该指导研究科学家发展奖申请描述了培训和研究计划，旨在使候选人有资格成为独立的心理健康研究人员，并具有共病精神病理学对病因学的影响的专业知识，分类和饮食失调的治疗。进食障碍人群中未识别的系统异质性可能会在不同研究中产生不一致的结果（例如，如果在不同的研究中以不同的比例输入异质亚组），并且模糊了关于病因、预后和治疗反应的临床相关信息。在这项申请中，研究计划的重点是了解如何异质性的模式共病情绪和焦虑精神病理学与治疗反应神经性厌食症（AN）患者。为此，情绪和焦虑障碍共病的基础结构将在150例AN患者中使用精神病学和气质的维度测量进行检查。参与者将在入院后1-2周进行急性（即，住院或日间医院）治疗，然后在出院后密切随访12个月，以确定共病亚型是否可用于确定AN治疗反应的预测因子。在跨学科导师团队的指导下，进行以下方面的高级培训：1）与AN患者研究相关的临床和病因因素; 2）精神病理学研究的维度方法;和3）用于识别临床亚组和建模纵向结果的数据分析技术将促进候选人建立专注于AN精神病理学和治疗的独立研究职业生涯的目标。关于AN患者在情绪和焦虑障碍症状和人格特征方面的差异的信息将通过确定新干预措施的潜在目标来促进治疗开发计划。此外，更好地了解急性治疗后立即出院期间与阴性结局相关的因素可能会导致更有效的治疗和复发预防计划的发展。最后，了解AN患者症状模式的显著差异可能会提供线索，促进对这种恶性疾病复杂原因的研究。