Benign Breast Disease: A New Frontier for Prevention

良性乳腺疾病：预防的新领域

• 批准号: 7369774
• 负责人: MARY Beryl DALY
• 金额: $ 11.58万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369774
• 关键词: Award; Awareness; Basic Science; Behavioral Sciences; Benign; Biological Assay; Biological Markers; Biology; Biopsy; Biopsy Specimen; Breast; Breast Cancer Prevention; Breast Diseases; Caring; Categories; Chemoprevention; Clinical; Clinical Management; Clinical Protocols; Collaborations; Community Healthcare; Counseling; Decision Aid; Decision Making; Diagnosis; Diagnostic; Discrimination; Disease Management; Education; Educational Status; Epidemiologic Studies; Family; Fellowship; Fostering; Genetic; Goals; Health; Health Promotion; Hereditary Malignant Neoplasm; Histopathology; Human Genome Project; Individual; Intervention; Lesion; Malignant Neoplasms; Malignant neoplasm of ovary; Mammography; Medical Oncology; Mentors; Molecular; Molecular Medicine; Nature; Normal tissue morphology; Outcome; Pathologist; Patients; Population; Population Sciences; Prevention; Prevention strategy; Preventive; Proteomics; Protocols documentation; Public Health; Randomized; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Rotation; Scientist; Screening procedure; Senior Scientist Award; Series; Standards of Weights and Measures; Students; Testing; Therapeutic; Time; Tissues; Training; Translational Research; Translations; Uncertainty; Underserved Population; Woman; Work; base; breast lesion; cancer prevention; cancer risk; career; coping; disorder prevention; frontier; improved; interest; laser capture microdissection; malignant breast neoplasm; novel; preference; prognostic; programs; prospective; psychologic; stem; theories; tumor molecular fingerprint

DESCRIPTION (provided by applicant): For the past twenty years, I have been involved with the care of women with breast and ovarian cancer, and their families. During that time my research focus has gradually shifted from management of the disease to its prevention. This direction has been enhanced by the work of the Human Genome Project, which has made tremendous progress in advancing our understanding of the genetic basis of cancer, and by the increased awareness on the part of both the public and the health care community of the tremendous potential for disease prevention and control. Building on this framework, I have developed a nationally recognized research-based program, defined by familial cancer risk, in which to explore novel education and counseling interventions and prevention strategies. I have formed longstanding collaborations with colleagues in the basic sciences, population sciences and behavioral sciences to foster translational research. I have contributed to the training of scientists at many levels who are new to the field of cancer prevention and control. I represent one of a handful of investigators in the field of cancer prevention and control who combines theory-driven research initiatives with actual translation to the clinical setting. At this point in my career, the K05 award will allow me to extend these efforts to a growing and underserved population of women who are at increased risk for breast cancer because of a diagnosis of benign breast disease. In the new era of molecular medicine, this population provides an ideal opportunity to study early molecular signatures of cancer risk, to identify genetic modifiers of risk, and to tailor preventive options to the biology of the lesion. The award will also facilitate my efforts to formalize a novel clinical genetics training rotation within the medical oncology fellowship, and will afford more opportunities to mentor students at all levels of training.

描述（由申请人提供）：在过去的二十年里，我一直参与照顾患有乳腺癌和卵巢癌的妇女及其家人。在此期间，我的研究重点逐渐从疾病管理转向疾病预防。人类基因组计划的工作在促进我们对癌症遗传基础的理解方面取得了巨大进展，公众和卫生保健社区对疾病预防和控制的巨大潜力的认识不断提高，从而加强了这一方向。在这个框架的基础上，我开发了一个全国公认的基于研究的项目，以家族癌症风险为定义，在这个项目中探索新的教育和咨询干预措施以及预防策略。我与基础科学、人口科学和行为科学领域的同事建立了长期合作关系，以促进转化研究。我为培训癌症预防和控制领域的许多新科学家做出了贡献。我是癌症预防和控制领域为数不多的研究人员之一，他们将理论驱动的研究倡议与实际转化为临床环境相结合。在我职业生涯的这个阶段，K05奖将使我能够将这些努力扩展到越来越多的、得不到充分服务的女性群体，她们因为被诊断为良性乳房疾病而患乳腺癌的风险增加。在分子医学的新时代，这一人群提供了一个理想的机会来研究癌症风险的早期分子特征，识别风险的遗传修饰因子，并根据病变的生物学特性量身定制预防方案。该奖项还将促进我在医学肿瘤学奖学金中正式建立一个新的临床遗传学培训轮转，并将提供更多的机会来指导各级培训的学生。