Breast cancer risk, distress, and biased cognitive processing of cancer words

乳腺癌风险、痛苦和癌症词汇的认知处理偏差

• 批准号: 7500875
• 负责人: Bonnie A McGregor
• 金额: $ 7.9万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-25 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7500875
• 关键词: Acute; Address; Affect; Anxiety; Behavioral; Biological; Cancer Patient; Chronic; Chronic stress; Clinical; Cognitive; Color; Communities; Computer information processing; Condition; Distress; Family history of; Health; Human; Hydrocortisone; Intervention; Laboratories; Literature; Malignant Neoplasms; Measures; Mediating; Mediator of activation protein; Mental Depression; Names; Operative Surgical Procedures; Participant; Patient Self-Report; Phobic anxiety disorder; Population; Process; Rate; Reaction Time; Reporting; Risk; Salivary; Sampling; Score; Stress; Task Performances; Testing; Thinking; Time Study; Week; Woman; Work; acute stress; biological adaptation to stress; cancer risk; chemotherapy; innovation; insight; malignant breast neoplasm; novel; peer; prophylactic; psychologic; psychological distress; selective attention; stress management; stressor

DESCRIPTION (provided by applicant): Women with a family history of breast cancer are at greater risk for breast cancer and can report elevated levels of chronic psychological distress as a result of how they perceive that risk. Chronic distress has been associated with increased reactivity to acute stressors in healthy populations and women with a family history of breast cancer. Evidence suggests acute stress reactivity interferes with the cognitive processing of threat- related information, including cancer words. One study has used a modified version of the Stroop color naming task to show that cancer words elicit cognitive processing interference among women with a family history of breast cancer. However, indicators of chronic distress were not associated with the biased cognitive processing in this sample, perhaps because they were not reporting elevated levels of chronic distress. The relationship between chronic stress, acute stress reactivity, and biased cognitive processing among women at risk for breast cancer is not clear. The present study will directly address this gap by administering the cancer Stroop task to a sample of family history positive and family history negative women who are reporting elevated levels of chronic distress. The proposed study will also measure and characterize the acute stress response that may be associated with taking the cancer Stroop task by including acute stress ratings and cortisol sampling before and after the task. Cortisol is one of the major biological indicators of stress in humans. Finally, the present study will test the effects of an existing 10-week CBSM intervention on distress and cancer Stroop task performance among the family history positive women. It is important to understand how chronic distress, acute stress reactivity and biased cognitive processing work among women at risk for breast cancer because women at risk for breast cancer are need to process information about how to manage their risk, for example whether to undergo prophylactic chemotherapies and surgeries.

描述（由申请人提供）：有乳腺癌家族史的妇女患乳腺癌的风险更大，并且由于她们如何看待这种风险，可以报告慢性心理困扰水平升高。在健康人群和有乳腺癌家族史的女性中，慢性痛苦与对急性压力源的反应性增加有关。有证据表明，急性应激反应会干扰对威胁相关信息的认知处理，包括癌症词汇。一项研究使用了Stroop颜色命名任务的修改版本，表明癌症单词会引起有乳腺癌家族史的女性的认知处理干扰。然而，在这个样本中，慢性痛苦的指标与有偏见的认知处理无关，也许是因为他们没有报告慢性痛苦的水平升高。慢性压力、急性压力反应和有乳腺癌风险的女性认知加工偏差之间的关系尚不清楚。本研究将直接解决这一差距，通过管理癌症Stroop任务的样本家族史阳性和家族史阴性的妇女谁是报告水平升高的慢性困扰。拟议的研究还将测量和表征可能与癌症Stroop任务相关的急性应激反应，包括任务前后的急性应激评分和皮质醇采样。皮质醇是人类压力的主要生物指标之一。最后，本研究将测试现有的10周CBSM干预对抑郁和癌症Stroop任务的表现在家族史阳性的妇女。重要的是要了解慢性痛苦，急性应激反应和有偏见的认知处理如何在有乳腺癌风险的女性中发挥作用，因为有乳腺癌风险的女性需要处理有关如何管理其风险的信息，例如是否接受预防性化疗和手术。