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Brief CBT for Anxiety and Advanced NSCLC

针对焦虑和晚期 NSCLC 的简短 CBT

基本信息

批准号：
7406760
负责人：
Joseph Andrew Greer
金额：
$ 8.75万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-13 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7406760
关键词：
Address Advanced Malignant Neoplasm Adverse effects Age Anxiety Arousal Arts Award Behavior Therapy Behavioral Behavioral Medicine Breast Cancer Patient Caring Cause of Death Clinical Clinical Research Clinical Treatment Cognition Cognitive Cognitive Therapy Comorbidity Complex Condition Depth Development Diagnosis Diagnostic Neoplasm Staging Disease Distal Distress Doctor of Philosophy Environment Epidemiology Feedback Gender General Hospitals Goals Guidelines Holly Hospitals Individual Intervention Interview Investigation Life Literature Living Wills Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Manuals Massachusetts Medical Medical Oncology Mental Depression Mental Health Mental disorders Mentorship Modeling Morbidity - disease rate Non-Small-Cell Lung Carcinoma Outcome Outpatients Pain Participant Patient Participation Patients Personal Satisfaction Pharmaceutical Preparations Phase Physiological Population Protocols documentation Provider Psychiatry Purpose Quality of life Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Rate Relaxation Research Research Personnel Sampling Schedule Screening procedure Services Staging Standards of Weights and Measures Symptoms Techniques Testing Thinking Thoracic Oncology Time Title Training Visit Waiting Lists Week abstracting base cancer care cancer diagnosis chemotherapy clinically significant contextual factors coping design experience improved innovation interest medical appointment novel oncology psychologic psychosocial research study satisfaction sex size therapy development treatment effect

项目摘要

DESCRIPTION (provided by applicant): Title: Brief CBT for Anxiety and Advanced NSCLC Project Summary/Abstract Overview: This is an application to develop and preliminarily test cognitive-behavioral therapy (CBT) for the treatment of anxiety in individuals with advanced non-small cell lung cancer (NSCLC). The overall goal is to lay the necessary groundwork for a full-scale randomized controlled trial of this treatment. Background: CBT for anxiety is an evidence-based, validated psychosocial intervention for anxiety which has not been examined in oncology patients in general or advanced lung cancer in particular. Lung cancer is the second most frequently diagnosed cancer and one of the leading causes of death in the U.S. Coping with this diagnosis can cause clinically significant, distressing, and interfering anxiety associated with impaired quality of life and worse medical outcomes. Research Plan: This study will follow NIH-defined guidelines for behavioral therapies development. Accordingly, there will be two phases. The first phase is to adapt state-of-the-art CBT for anxiety to the specific population of patients with advanced NSCLC. This will involve conducting qualitative interviews to obtain feedback from patients with advanced lung cancer on the components of CBT for anxiety, developing an outline of a treatment manual, and piloting the intervention openly. The second phase is a pilot randomized controlled trial of the psychosocial intervention following the treatment manual outline to examine patient acceptability, feasibility of delivery, and an estimation of the effect size for anxiety reduction and improvement in quality of life. Environment: The study will take place at Massachusetts General Hospital, drawing on the clinical and research expertise of the Centers for Cancer Care (the Thoracic Oncology Service) and the Department of Psychiatry's Behavioral Medicine Service which has considerable expertise in cognitive behavioral therapy development and testing. The timely opportunity for study recruitment is facilitated by ongoing research in the Thoracic Oncology Service that will be screening for psychiatric distress in individuals with lung cancer. Mentorship will be provided by Steven Safren, PhD and Holly Prigerson, PhD, nationally-recognized experts in the development and testing of CBT protocols for diverse medical populations and the assessment and epidemiology of psychological disorders among patients with advanced cancer, respectively. Relevance of Research: The study will further understanding of the impact of anxiety on advanced cancer patients. Novel interventions for alleviating distress and improving quality of life will be developed. Approximately 30% of patients with advanced lung cancer experience debilitating anxiety symptoms that are associated with worse medical and psychosocial outcomes. The purpose of the present investigation is to develop and pilot test a behavioral intervention that can be delivered to oncology patients in a timely and accessible manner. Through this study, we will gain a deeper understanding of the psychosocial needs of patients with advanced lung cancer as well as create a state-of-the-art behavioral intervention that addresses these concerns and improves patients' overall quality of life.

项目简介/摘要概述：本项目旨在开发并初步测试认知行为疗法（CBT）治疗晚期非小细胞肺癌（NSCLC）患者焦虑的应用。总体目标是为这种治疗的全面随机对照试验奠定必要的基础。背景：CBT治疗焦虑是一种以证据为基础的、有效的焦虑心理社会干预，尚未在一般肿瘤患者或晚期肺癌患者中进行过研究。肺癌是美国第二大最常诊断的癌症，也是导致死亡的主要原因之一。应对这一诊断可能会导致临床上显著的、痛苦的、干扰性的焦虑，与生活质量受损和更糟糕的医疗结果相关。研究计划：本研究将遵循美国国立卫生研究院定义的行为疗法发展指南。因此，将分为两个阶段。第一阶段是将最先进的CBT用于治疗焦虑，以适应晚期非小细胞肺癌患者的特定人群。这将包括进行定性访谈，以获得晚期肺癌患者对CBT治疗焦虑成分的反馈，制定治疗手册大纲，并公开试点干预措施。第二阶段是根据治疗手册大纲进行社会心理干预的随机对照试验，以检查患者的可接受性、实施的可行性，并估计减少焦虑和改善生活质量的效应大小。环境：该研究将在马萨诸塞州总医院进行，利用癌症护理中心（胸部肿瘤学服务）和精神病学行为医学服务部门的临床和研究专业知识，后者在认知行为治疗开发和测试方面具有相当大的专业知识。胸科肿瘤学服务正在进行的研究将筛查肺癌患者的精神困扰，这为研究招募提供了及时的机会。指导将由Steven Safren博士和Holly Prigerson博士提供，他们分别是针对不同医疗人群开发和测试CBT协议以及晚期癌症患者心理障碍评估和流行病学方面的国家公认专家。研究意义：本研究将进一步了解焦虑对晚期癌症患者的影响。新的干预措施，以减轻痛苦和提高生活质量将被开发。大约30%的晚期肺癌患者会出现令人衰弱的焦虑症状，这些症状与较差的医疗和社会心理结局相关。本研究的目的是开发和试点测试一种行为干预，可以提供给肿瘤患者及时和方便的方式。通过这项研究，我们将更深入地了解晚期肺癌患者的心理社会需求，并创造一种最先进的行为干预方法来解决这些问题，提高患者的整体生活质量。