ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVE

青少年酗酒：双胞胎研究的视角

• 批准号: 7433937
• 负责人: Richard Joseph Rose
• 金额: $ 26.99万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433937
• 关键词: Adolescent; Alcohol abuse; Authorization documentation; Cities; Disclosure; Face; Finland; Human Resources; Indiana; Institutes; Instruction; Last Name; Names; Numbers; Principal Investigator; Printing; Progress Reports; Public Health; Research; Research Personnel; Research Project Grants; Role; Rosa; Site; Twin Studies; Universities; Washington; abstracting; programs

DESCRIPTION: Submitted in response to RFA AA-99-003, this application requests five years’ support to study consequences and mechanisms of adolescent alcohol abuse in adult and adolescent twin pairs. The research proposal builds on two ongoing twin-family studies conducted in Finland. One study, FinnTwin16, has ascertained 2,800 twin pairs, born 1975-79, and assessed them, and their parents, with questionnaires, in 1991-1995, as the twins reached age 16; follow-up questionnaire assessments of the twins were made at ages 17 and 18 1/2. We propose a fourth questionnaire assessment of all these Finnish twins, at ages 22-25, to evaluate their adult use/abuse of alcohol and their social, educational, occupational and interpersonal competencies. From the adolescent questionnaire assessments, we have identified >200 dizygotic twin pairs for intensive follow-up; the targeted cotwins were selected for extreme concordance or extreme discordance for adolescent alcohol abuse. At ages 22-25, we will interview them with the Semi-Structured Assessment for Genetics of Alcoholism (SSAGA), access them with a neuropsychological test battery and evaluate their electrophysiological function with ERP paradigms. These within-family comparisons of co-twins discordant for adolescent alcohol abuse will robustly test for its consequences. To compliment this appraisal of early adult consequences of adolescent problem drinking, we propose intensive study of two birth cohorts from a second on-going study, FinnTwin12; 485 twin pairs, born 1986-87, are selected for intensive study in that project with 50% at elevated familial risk for alcoholism. At age 14, in years 2000-01, these twin pairs will be interviewed with the adolescent SSAGA (with other funding), and as part of this proposal, we will append to the interview an enriched neuropsychological test battery and assay testosterone and cortisol from saliva. Jointly, these neurophysiological, neuropsychological, and neuroendocrine studies of targeted Finnish twins, for whom risk-relevant data have been collected earlier, will offer incisive analyses of neurobiological mechanisms and consequences of alcohol abuse in adolescence.

描述：此申请是响应 RFA AA-99-003 提交的 要求五年的支持来研究后果和机制 成人和青少年双胞胎中的青少年酒精滥用。研究 该提案以芬兰正在进行的两项双胞胎家庭研究为基础。一 FinnTwin16 研究已确定 2,800 对双胞胎，出生于 1975-79 年， 1991-1995 年，通过问卷调查对他们及其父母进行了评估 双胞胎年满16岁；对双胞胎的后续问卷评估是 制作于 17 岁和 18 1/2 岁。我们提出第四次问卷评估 所有这些 22 至 25 岁的芬兰双胞胎，评估他们在成年后的使用/滥用情况 酒精及其社会、教育、职业和人际关系 能力。从青少年问卷评估中，我们得到 确定了超过 200 对异卵双胞胎进行强化随访；目标双胞胎 被选择为极端一致或极端不一致 青少年酗酒。在 22-25 岁期间，我们将采访他们 酒精中毒遗传学半结构化评估 (SSAGA)，访问它们 使用神经心理学测试电池并评估他们的电生理学 与 ERP 范例一起运行。这些双胞胎的家庭内部比较 青少年酗酒的不一致将对其进行强有力的测试 结果。为了赞扬这种对早期成人后果的评估 青少年饮酒问题，我们建议对两个出生队列进行深入研究 来自第二项正在进行的研究 FinnTwin12； 485 对双胞胎，出生于 1986-87 年， 选择在该项目中进行强化研究，其中 50% 的人在高家族 酗酒的风险。 2000-01 年，14 岁时，这对双胞胎将成为 采访了青少年 SSAGA（有其他资助），并作为 根据这个建议，我们将在采访中附加丰富的神经心理学内容 测试电池并测定唾液中的睾酮和皮质醇。共同地，这些 神经生理学、神经心理学和神经内分泌学的靶向研究 先前已收集了芬兰双胞胎的风险相关数据，他们将 对神经生物学机制和后果进行深入分析 青春期酗酒。