Reinforcement as a Prospective Predictor of Real-time Alcohol Abuse Following Bariatric Surgery

强化作为减肥手术后实时酒精滥用的前瞻性预测因子

• 批准号: 10370120
• 负责人: SCOTT G ENGEL
• 金额: $ 25.9万
• 依托单位: SANFORD RESEARCH NORTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10370120
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Anatomy; Bariatrics; Behavioral; Biological; Blood alcohol level measurement; Body Weight decreased; Clinical; Data; Development; Dose; Drug Kinetics; Ecological momentary assessment; Environment; Family; Foundations; Frequencies; Future; Gastrectomy; Gastric Bypass; Grant; Health Benefit; Individual; Intervention; Investigation; Knowledge; Laboratories; Lead; Life; Measures; Mental Health; Methodology; Minority; Monitor; Neurocognitive; Onset of illness; Operative Surgical Procedures; Outcome; Paper; Patients; Peptides; Physiological; Play; Postoperative Period; Prevention; Procedures; Psychological reinforcement; Publishing; Recording of previous events; Reporting; Research; Resolution; Rewards; Risk; Role; Severities; Societies; Substance abuse problem; Symptoms; System; Time; Weight; alcohol effect; alcohol intervention; alcohol measurement; alcohol misuse; alcohol reinforcement; alcohol risk; alcohol use disorder; bariatric surgery; base; cohort; comorbidity; critical period; design; drinking; drinking behavior; economic behavior; experience; high risk; large datasets; physical conditioning; prospective; psychosocial; racial diversity; surgery outcome; weight loss intervention

ABSTRACT Recent research has clearly shown that when compared to before surgery, post-bariatric surgery patients are at increased risk for alcohol use disorders and increased alcohol intake. Understanding the mechanisms that contribute to these negative clinical outcomes is of considerable scientific and clinical importance. In the present study, we propose to investigate the extent to which changes in the reinforcement of alcohol lead to increased alcohol intake in post-bariatric surgery patients. We will employ momentary naturalistic assessment, objective continuous alcohol measurement, and laboratory methodology to carefully assess reinforcement using an empirically supported behavior economics-based measure. Additionally, this study is designed as a prospective, longitudinal investigation that will follow bariatric surgery patients from one year to two years after surgery.

摘要 最近的研究清楚地表明，与手术前相比，减肥手术后的患者 酒精使用障碍和酒精摄入量增加的风险增加。了解以下机制 造成这些负面的临床结果具有相当重要的科学和临床意义。在 目前的研究，我们建议调查酒精强化的变化导致的程度 减肥手术后患者酒精摄入量增加。我们将采用瞬间的自然主义评估， 目的连续酒精测量和实验室方法学仔细评估强化 使用经验支持的基于行为经济学的衡量标准。此外，这项研究被设计为一种 对减肥手术患者进行一年至两年的前瞻性纵向调查 做手术。