权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

In Vivo Cancer Therapy Monitoring with Diffuse Optical Methods

使用漫射光学方法监测体内癌症治疗

基本信息

批准号：
7470357
负责人：
REGINE CHOE
金额：
$ 8.12万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-08 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7470357
关键词：
Acidity Adriamycin PFS Algorithms Animal Model Animals Autoradiography Biometry Blood Blood Vessels Blood flow Breast Cancer Patient Clinic Clinical Condition Cyclophosphamide Daily Deoxyglucose Depth Detection Devices Diagnosis Diffuse Dyes Education Environment Fever Fluorescence Fluorescence Microscopy Fluorochrome Functional disorder Glucose Goals Hand Hematology Hemoglobin Heterogeneity Human Hydralazine Image Individual Injection of therapeutic agent Invasive Light Lipids Malignant Neoplasms Mammary Neoplasms Measurable Measurement Measures Mentors Metabolic Metabolism Modality Monitor Mus Neoadjuvant Therapy Niacinamide Operative Surgical Procedures Optical Methods Optics Outcome Oxygen Paclitaxel Palpation Pathway interactions Pennsylvania Performance Phase Physics Physiology Plants Positron-Emission Tomography Property Radiology Specialty Range Recruitment Activity Research Research Personnel Sensitivity and Specificity Slice Spectrum Analysis Staging Surgical Pathology Surrogate Markers System Technology Therapeutic Time Tissues Tracer Training Translating Treatment Efficacy Tumor Biology Tumor Cell Line Ultrasonography United States National Institutes of Health Universities Variant Water Woman Work Xenograft Model analog base cancer therapy chemotherapy diffuse optical tomography experience feeding fluorescence imaging glucose metabolism glucose monitor hemodynamics hyperthermia treatment improved in vivo indexing instrument instrumentation malignant breast neoplasm molecular imaging neoplastic cell oncology pre-clinical programs response size therapy outcome trend tumor uptake

项目摘要

DESCRIPTION (provided by applicant): My long-range goal is to assess and improve the capability of diffuse optical methods in detection, diagnosis and therapeutic monitoring of breast cancer. Diffuse optical methods using near-infrared light provide several unique functional parameters (such as total hemoglobin concentration, blood oxygen saturation, blood flow, water and lipid concentration) to enhance tumor sensitivity and specificity. Moreover, deep tissue micro-environment (e.g. vascular leakiness, acidity) can be probed with diffuse fluorescence imaging/spectroscopy. Diffuse optical methods can impact on cancer therapy monitoring and planning at early stages since the metabolic changes due to therapy may precede the anatomical size changes measured by clinical palpation or conventional imaging modalities. I have worked on diffuse optical tomography to detect and characterize breast cancer for -10 years at the University of Pennsylvania. I have acquired excellent education and experience in instrumentation and numerical analysis and also got valuable clinical experience. However, as the research is growing rapidly and expanding more into the clinical regime, more in-depth biomedical training is becoming necessary to translate the diffuse optical technology into the clinic. Therefore, I am proposing to expand my horizons under my mentor, Dr. Arjun Yodh from Physics department and co-mentors, Dr. Mitchell Schnall, Dr. Jerry Glickson from Radiology and Dr. Angela DeMichele from Hematology-Oncology. During this mentored phase (K99), I will take courses to get fundamental training on tumor biology and physiology as well as biostatistics. For K99 research, I will explore the utility of portable diffuse optical device to assess neoadjuvant chemotherapy response of subjects with breast cancer. In the subsequent independent investigator phase (ROO), I will compare fluorescence diffuse optical method using a new optical dye whose concentration corresponds to glucose level with autoradiography/PET on mouse xenograft model of human breast cancer. Once I establish the performance of this dye, I will use it as a surrogate marker for glucose metabolism. I will investigate whether simultaneous monitoring of glucose and oxygen metabolism accessible by all optical methods can enhance the assessment of treatment efficacy. This independent research will pave the ways for molecular imaging in vivo for therapy monitoring and diagnosis when it becomes available for human use.

描述(申请人提供)：我的长期目标是评估和提高漫反射光学方法在乳腺癌检测、诊断和治疗监测中的能力。利用近红外光的漫反射光学方法提供了几个独特的功能参数(如总血红蛋白浓度、血氧饱和度、血流量、水和脂肪浓度)来提高肿瘤的敏感性和特异性。此外，还可以利用漫反射荧光成像/光谱分析来探测深层组织微环境(如血管渗漏、酸度)。扩散光学方法可能会在早期阶段影响癌症治疗的监测和计划，因为治疗引起的代谢变化可能先于临床触诊或传统成像方式测量的解剖大小变化。我在宾夕法尼亚大学从事漫反射光学断层扫描以检测和确定乳腺癌的特征已有10年。我在仪器和数值分析方面获得了良好的教育和经验，也获得了宝贵的临床经验。然而，随着研究的迅速发展，越来越多的研究扩展到临床，更深入的生物医学培训变得必要，以将漫反射光学技术转化为临床。因此，我提议在我的导师，物理系的Arjun Yodh博士和共同导师Mitchell Schnall博士，放射科的曾傑瑞博士和血液肿瘤科的Angela DeMichele博士的指导下，扩大我的视野。在这个指导阶段(K99)，我将参加有关肿瘤生物学和生理学以及生物统计学的基础培训课程。对于K99研究，我将探索便携式漫反射光学设备在评估乳腺癌患者新辅助化疗反应方面的应用。在随后的独立研究阶段(Roo)，我将在小鼠人乳腺癌移植模型上比较使用一种新的荧光染料的荧光漫射光学方法和放射自显影/PET。一旦我确定了这种染料的性能，我将把它作为葡萄糖代谢的替代标记物。我将研究是否可以通过所有光学方法同时监测葡萄糖和氧代谢，以增强对治疗效果的评估。这项独立的研究将为活体分子成像为治疗、监测和诊断铺平道路，当它可供人类使用时。