Larva to Butterfly:Training as Systems Cancer Biologist

幼虫到蝴蝶：系统癌症生物学家的培训

• 批准号: 7476450
• 负责人: SREE N SREENATH
• 金额: $ 14.61万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476450
• 关键词: Active Learning; Apoptosis; Area; Award; Beds; Behavior; Binding; Biological; Biological Phenomena; Biological Sciences; Biology; Butterflies; Cancer Biology; Cancer Center; Categories; Cell Cycle; Cell Nucleus; Cell physiology; Cells; Chemistry; Clinical Treatment; Complex; Computer Analysis; Computer Simulation; Controlled Study; Cytoplasm; Economics; Educational Curriculum; Engineering; Equilibrium; Evolution; Facility Construction Funding Category; Feedback; Gene Expression; General Systems Theory; Goals; Growth; Health; Helix (Snails); Image; In Vitro; Interdisciplinary Study; Knowledge; Language Development; Larva; Learning; Literature; MEKs; Malignant Neoplasms; Mammalian Cell; Mathematics; Measures; Mentors; Modeling; Molecular Biology; Motivation; Neoplasm Metastasis; Nobel Prize; Nurses; Oncogenes; Pathway interactions; Personal Satisfaction; Pharmacology; Physicians; Physics; Process; Property; Protocols documentation; Qualitative Research; Range; Ras/Raf; Regulator Genes; Research; Research Personnel; Research Project Grants; Rotation; Science; Scientist; Signal Pathway; Signal Transduction; Solutions; Specialist; Standards of Weights and Measures; Structure; Students; System; Systems Analysis; Systems Biology; Systems Theory; Techniques; Time; Tissues; Training; Tumor Suppressor Genes; Universities; Validation; Variant; Water; Work; abstracting; angiogenesis; base; behavior influence; concept; data collection methodology; demographics; design; ear helix; experience; feeding; hydrology; in vivo; interest; novel strategies; programs; research study; resilience; response; tumor

DESCRIPTION (provided by applicant): Complexity is a hallmark of any biological system. In my K25 award period I will focus on applying Systems Science approaches to cancer biology in the context of complex systems, and transform myself into a Systems Cancer Biologist. As a System Scientist with two decades of experience, it was required of me to learn diverse fields quickly enough to collaborate with specialists in such dissimilar fields as astrodynamics, demographics, economics, engineering, health, hydrology, physics, and water chemistry. Interdisciplinary research requires 'learning the language' - i.e., to converse with disciplinary specialists to jointly define problems, understanding and, search for solutions. With an experiential learning approach with guidance from my mentors and collaborator, during my K25 period, I will develop specific 'small' research projects as a vehicle for learning about important cancer problems. Lab rotations in biology, imaging, pharmacology, etc., supplements knowledge, and in appreciating data collection, methodology and protocols, needed for model validation, analysis verification - essentially in silico approach, that leads to in vitro. The in vivo experiments will be in the longer term. With my quantitative and qualitative research background, I will focus on inter- and intra-cell signaling pathways, in particular JAK-STAT and Ras-Raf-MEK-ERK, and, on transcriptional and post-transcriptional gene expression networks. Understanding cross-talk and regulatory gene network behavior, requires defining problems using goal seeking, coordination, bounded autonomy, resilience and robustness paradigms, and the application of systems science approaches of multilevel and hierarchical systems theory, coordination and control. Cell functions such as apoptosis, angiogenesis, tissue invasion, proliferation, metastasis and differentiation, important in cancer biology will provide motivation for this research. Over the next two decades I will work to be a leader and co-leader with cancer biologists and, collaborate with physicians- essentially bench-to-bed. As an educator, I will create a Systems Cancer Biology course to train a new cadre of students in both engineering and cancer biology. In the longer term I will co-develop a curriculum to replicate my experience in creating more Systems Cancer Biologists.

描述（由申请人提供）：复杂性是任何生物系统的标志。 在我的 K25 奖励期间，我将专注于在复杂系统的背景下将系统科学方法应用于癌症生物学，并将自己转变为系统癌症生物学家。 作为一名拥有二十年经验的系统科学家，我需要足够快地学习不同领域，以便与天体动力学、人口统计学、经济学、工程、健康、水文学、物理学和水化学等不同领域的专家合作。 跨学科研究需要“学习语言”——即与学科专家交谈，共同定义问题、理解问题并寻找解决方案。 在导师和合作者的指导下，通过体验式学习方法，在 K25 期间，我将开发特定的“小型”研究项目，作为了解重要癌症问题的工具。 生物学、成像、药理学等方面的实验室轮换补充了知识，并在欣赏模型验证、分析验证所需的数据收集、方法和协议方面——本质上是在计算机方法中，这导致了体外。 体内实验将是长期的。 凭借我的定量和定性研究背景，我将重点关注细胞间和细胞内信号通路，特别是 JAK-STAT 和 Ras-Raf-MEK-ERK，以及转录和转录后基因表达网络。 了解串扰和调控基因网络行为，需要使用目标寻求、协调、有限自主、弹性和鲁棒性范式来定义问题，以及应用多级和分层系统理论、协调和控制的系统科学方法。 在癌症生物学中重要的细胞功能，如凋亡、血管生成、组织侵袭、增殖、转移和分化，将为这项研究提供动力。 在接下来的二十年里，我将努力成为癌症生物学家的领导者和共同领导者，并与医生合作——基本上是从工作台到床上。 作为一名教育家，我将创建一门系统癌症生物学课程，以培训工程和癌症生物学方面的新学生骨干。 从长远来看，我将共同开发一门课程，以复制我在培养更多系统癌症生物学家方面的经验。