Patient-oriented research in early life origins of CVD

描述（由申请人提供）： 不仅在成年生活中，而且从概念中起作用的因素对终身心血管健康产生影响。动物和人类研究，包括我们自己的研究，现在正在为儿童肥胖和心血管风险的产前和围产期决定因素提供有趣的线索。但缺乏前瞻性数据，转化为预防性干预措施才刚刚开始。Gillman博士和他的学员将在未来五年集中精力研究这一领域，这不仅是该领域本身的关键时期，也是继续扩大他的潜力，做出重大贡献，培养该领域下一代以患者为导向的研究人员的关键时期。这项建议的具体目标是：（1）研究儿童肥胖症和心血管危险因素的产前和围产期决定因素。这些分析将利用正在进行的NIH资助的Viva项目提供的基础设施，该项目是一项针对孕妇及其子女的前瞻性队列研究。(2)提供一个滋养的专业环境，培训和晋升的开始临床研究人员，谁将在项目Viva和其他正在进行的以患者为导向的研究项目中进行研究，在该地区的生命过程的方法，以慢性疾病。主要焦点将集中在以下领域：（1）肥胖、心血管风险、哮喘和认知的产前和围产期起源;（2）青春期饮食和体育活动的决定因素;（3）预防幼儿肥胖的创新干预措施。

DESCRIPTION (provided by applicant): Factors operating not only in adult life, but also from conception, have impact on lifelong cardiovascular health. Animal and human studies, including our own, are now providing intriguing clues into the pre- and perinatal determinants of childhood obesity and cardiovascular risk. But prospective data are lacking, and translation into preventive interventions has only just begun. With the support from this K24 competing continuation grant, Dr. Gillman and his mentees will focus intensively on this area of research for the next five years, a critical period not only for the field itself, but also for continuing to expand his potential for significant contributions and for nurturing the next generation of patient-oriented researchers in this field. The specific aims of this proposal are (1) To examine pre- and perinatal determinants of childhood obesity and cardiovascular risk factors. These analyses will take advantage of the infrastructure provided by the ongoing NIH-funded Project Viva, a prospective cohort study of pregnant women and their children. (2) To provide a nourishing professional environment for the training and advancement of beginning clinical researchers, who will conduct studies within Project Viva and other ongoing patient-oriented research projects in the area of the life course approach to chronic disease. Major foci will be in the areas of (1) pre- and perinatal origins of obesity, cardiovascular risk, asthma, and cognition; (2) determinants of diet and physical activity in adolescence; and (3) innovative interventions to prevent obesity in young children.