SAN DIEGO LATINO RESEARCH CENTER OF EXCELLENCE PARTNERSHIP TO REDUCE CVD DISPARIT

圣迭戈拉丁裔卓越研究中心：合作减少心血管疾病 拉美裔美国人的差异 圣地亚哥拉丁裔卓越研究中心是一个三方合作组织，旨在促进 并加快研究，改善低收入拉丁裔人的糖尿病和心血管疾病结局 住在圣地亚哥的边境地区。圣地亚哥州立大学(SDSU)和加州大学 圣地亚哥大学(UCSD)代表着两所大型研究密集型大学，其中一所拥有公共卫生学院和 另一个有医学院学历，但有社区研究的经验和兴趣 训练。圣伊西德罗健康中心(SYHC)是一个大型的、主要为拉丁裔服务的社区卫生中心 为弱势患者提供服务的中心，也有研究中心。SYHC由以下机构授权 卫生资源和服务管理局(HRSA)参与名为卫生的联邦倡议 差异协作(HOC)。HOC使用计划护理模式和模式的方法来 在以社区为导向的初级保健的背景下改进，以积极改变人民的生活 数十万美国人(BPCHC，2006)。 圣地亚哥拉丁裔卓越研究中心建议将重点放在糖尿病和 低收入拉丁裔经历的心血管疾病(CVD)及其相关生物行为危险因素 住在圣地亚哥边境地区。主要研究计划建议进行随机临床试验评估 实施国家胆固醇教育计划的两种文化适宜方法的效果 (NCEP，2001)和美国糖尿病协会(ADA，2001)指南。干预的重点 方法包括患者自我管理、递送系统设计、临床信息系统 和决策支持，这是HDC计划护理模式的所有关键要素。创新包括使用 双语社区卫生工作者，遵守障碍的环境评估，文化上的适当 基于理论模型和颈动脉内膜中层厚度使用的行为策略 (CIMT)是以拉丁裔为主的队列中的主要结果。融入干预研究 设计是心血管疾病横断面研究的能力，例如，识别遗传风险因素和 拉丁裔人群特有的基因-环境相互作用、嵌套式病例对照研究和银行血清 以吸引新的调查人员，并扩大该提案的科学能力。 培训核心计划提出了一个培训方案，重点是现有的培训方案和 每个合作伙伴的长处。SDSU和UCSD将提供研究方法方面的培训和指导 对心血管疾病差异研究感兴趣的少数族裔调查人员和对健康感兴趣的非少数族裔调查人员 差距。SYHC将提供关注人群和差异研究的环境，以及 对拉丁裔社区有深入了解的临床医生。

SAN DIEGO LATINO RESEARCH CENTER OF EXCELLENCE: PARTNERSHIP TO REDUCE CVD DISPARITIES IN LATINOS The San Diego Latino Research Center of Excellence is a tri-lateral collaboration that seeks to promote and expedite research that improves diabetes and cardiovascular disease outcomes in low-income Latinos living in the border region of San Diego. San Diego State University (SDSU) and the University of California, San Diego (UCSD) represent two large research intensive universities, one with a school of public health and the other with a school of medicine but both with experience and interest in community based research and training. The San Ysidro Health Center (SYHC) is a large, predominantly Latino-serving community health center that provides services to disadvantaged patients and also has a research center. SYHC is mandated by the Health Resources and Service Administration (HRSA) to engage in the Federal Initiative called the Health Disparities Collaborative (HOC). The HOC uses the methodology of the Planned Care Model and the Model for Improvement in the context of Community Oriented Primary Care to make a positive difference in the lives of hundreds of thousands of Americans (BPCHC, 2006). The San Diego Latino Research Center of Excellence proposes to focus on the disparities in diabetes and cardiovascular disease (CVD) and its associated bio-behavioral risk factors experienced by low-income Latinos living in the San Diego border region. The main research plan proposes a randomized clinical trial evaluating the efficacy of 2 culturally appropriate methods for applying the National Cholesterol Education Program (NCEP, 2001) and the American Diabetes Association (ADA, 2001) guidelines. The focus of the intervention methods includes strategies that patient self management, delivery system design, clinical information systems and decision support, all key elements of the HDC Planned Care Model. Innovations include the use of bilingual Community Health Workers, environmental assessments for barriers to adherence, culturallyappropriate behavioral strategies based on a theoretical model and the use of carotid intimal medial thickness (CIMT) as the primary outcome in a predominantly Latino cohort. Integrated into the intervention research design is the capacity for CVD cross-sectional studies, for example, identification of genetic risk factors and gene-environment interactions specific to the Latino population, nested case-control studies and banked serum to attract new investigators and expand the scientific capacity of the proposal. The training core plan proposes a training program that focuses on the existing training programs and the strengths of each partner. SDSU and UCSD will supply the training and mentoring in research methods for minority investigators interested in CVD disparities research and non-minority investigators interested in health disparities. The SYHC will provide the population of focus and the setting for disparities research and the clinicians with intimate knowledge of the Latino community.