SAN DIEGO LATINO RESEARCH CENTER OF EXCELLENCE PARTNERSHIP TO REDUCE CVD DISPARIT

圣地亚哥拉丁卓越研究中心：减少CVD的伙伴关系 拉丁美洲的差距 卓越的圣地亚哥拉丁裔研究中心是一个三边合作，旨在促进 并加快改善低收入拉丁美洲人糖尿病和心血管疾病结局的研究 住在圣地亚哥的边境地区圣地亚哥州立大学（SDSU）和加州大学， 圣地亚哥大学（UCSD）代表了两所大型研究密集型大学，一所是公共卫生学院， 另一个拥有医学院，但在社区研究方面都有经验和兴趣， 训练圣伊西德罗健康中心（SYHC）是一个大型的，主要为拉丁美洲人服务的社区健康中心。 该中心为弱势患者提供服务，也有一个研究中心。SYHC由以下机构授权： 卫生资源和服务管理局（HRSA）参与联邦倡议，称为健康 差异协作（HOC）。HOC使用计划性护理模式和 改善面向社区的初级保健，积极改善 成千上万的美国人（BPCHC，2006年）。 圣地亚哥拉丁裔卓越研究中心建议重点关注糖尿病和糖尿病的差异， 低收入拉丁美洲人经历的心血管疾病（CVD）及其相关的生物行为风险因素 住在圣地亚哥边境地区主要研究计划提出了一项随机临床试验， 2种文化上适当的方法应用国家胆固醇教育计划的有效性 (NCEP，2001）和美国糖尿病协会（ADA，2001）指南。干预的重点 方法包括患者自我管理、输送系统设计、临床信息系统等策略 和决策支持，HDC计划护理模式的所有关键要素。创新包括使用 双语社区卫生工作者，依从性障碍的环境评估，文化适宜 基于理论模型和使用颈动脉内膜中层厚度的行为策略 （CIMT）作为主要结果在一个主要拉丁裔队列。纳入干预研究 设计是心血管病横断面研究的能力，例如，识别遗传风险因素， 拉丁美洲人群特有的基因-环境相互作用、巢式病例对照研究和库存血清 以吸引新的研究人员，并扩大该提案的科学能力。 培训核心计划提出了一个培训方案，重点是现有的培训方案和 每个合作伙伴的优势。SDSU和UCSD将提供研究方法的培训和指导， 对CVD差异研究感兴趣的少数民族研究者和对健康感兴趣的非少数民族研究者 差距。SYHC将提供重点人群和差异研究的背景， 对拉丁裔社区有深入了解的临床医生。

SAN DIEGO LATINO RESEARCH CENTER OF EXCELLENCE: PARTNERSHIP TO REDUCE CVD DISPARITIES IN LATINOS The San Diego Latino Research Center of Excellence is a tri-lateral collaboration that seeks to promote and expedite research that improves diabetes and cardiovascular disease outcomes in low-income Latinos living in the border region of San Diego. San Diego State University (SDSU) and the University of California, San Diego (UCSD) represent two large research intensive universities, one with a school of public health and the other with a school of medicine but both with experience and interest in community based research and training. The San Ysidro Health Center (SYHC) is a large, predominantly Latino-serving community health center that provides services to disadvantaged patients and also has a research center. SYHC is mandated by the Health Resources and Service Administration (HRSA) to engage in the Federal Initiative called the Health Disparities Collaborative (HOC). The HOC uses the methodology of the Planned Care Model and the Model for Improvement in the context of Community Oriented Primary Care to make a positive difference in the lives of hundreds of thousands of Americans (BPCHC, 2006). The San Diego Latino Research Center of Excellence proposes to focus on the disparities in diabetes and cardiovascular disease (CVD) and its associated bio-behavioral risk factors experienced by low-income Latinos living in the San Diego border region. The main research plan proposes a randomized clinical trial evaluating the efficacy of 2 culturally appropriate methods for applying the National Cholesterol Education Program (NCEP, 2001) and the American Diabetes Association (ADA, 2001) guidelines. The focus of the intervention methods includes strategies that patient self management, delivery system design, clinical information systems and decision support, all key elements of the HDC Planned Care Model. Innovations include the use of bilingual Community Health Workers, environmental assessments for barriers to adherence, culturallyappropriate behavioral strategies based on a theoretical model and the use of carotid intimal medial thickness (CIMT) as the primary outcome in a predominantly Latino cohort. Integrated into the intervention research design is the capacity for CVD cross-sectional studies, for example, identification of genetic risk factors and gene-environment interactions specific to the Latino population, nested case-control studies and banked serum to attract new investigators and expand the scientific capacity of the proposal. The training core plan proposes a training program that focuses on the existing training programs and the strengths of each partner. SDSU and UCSD will supply the training and mentoring in research methods for minority investigators interested in CVD disparities research and non-minority investigators interested in health disparities. The SYHC will provide the population of focus and the setting for disparities research and the clinicians with intimate knowledge of the Latino community.