Spatio-temporal structural and functional studies into the novel interaction between LIMD1 and clathrin heavy chain proteins

LIMD1 与网格蛋白重链蛋白之间新型相互作用的时空结构和功能研究

• 批准号: BB/F006470/1
• 负责人: Tyson Sharp
• 金额: $ 41.79万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF006470%2F1
• 关键词: Spatio; temporal; structural; functional; studies

We have identified the LIMD1 gene that may be damaged or lost in many human diseases and cancers. In order to determine why this protein is so important for human health we performed experiment to determine how this protein functions. We subsequently discovered that LIMD1 interacts with a subset of proteins the function of which is to regulate a critical cellular process called endocytosis. Thus LIMD1's ability to regulate cell growth and proliferation could be through novel interactions with key regulators of endocytosis.

我们已经确定了LIMD1基因，该基因可能在许多人类疾病和癌症中受损或丢失。为了确定为什么这种蛋白质对人类健康如此重要，我们进行了实验来确定这种蛋白质的功能。我们随后发现，LIMD1与一个蛋白质子集相互作用，其功能是调节一个称为内吞的关键细胞过程。因此，LIMD1调节细胞生长和增殖的能力可能是通过与内吞作用的关键调节因子的新型相互作用。

项目成果

CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.

• DOI: 10.1158/0008-5472.can-15-3134
• 发表时间: 2016-08-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Feber A;Worth DC;Chakravarthy A;de Winter P;Shah K;Arya M;Saqib M;Nigam R;Malone PR;Tan WS;Rodney S;Freeman A;Jameson C;Wilson GA;Powles T;Beck S;Fenton T;Sharp TV;Muneer A;Kelly JD
• 通讯作者: Kelly JD

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

• DOI: 10.1016/j.febslet.2011.03.013
• 发表时间: 2011-04-06
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Foxler DE;James V;Shelton SJ;Vallim TQ;Shaw PE;Sharp TV
• 通讯作者: Sharp TV