Spatio-temporal structural and functional studies into the novel interaction between LIMD1 and clathrin heavy chain proteins

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We have identified the LIMD1 gene that may be damaged or lost in many human diseases and cancers. In order to determine why this protein is so important for human health we performed experiment to determine how this protein functions. We subsequently discovered that LIMD1 interacts with a subset of proteins the function of which is to regulate a critical cellular process called endocytosis. Thus LIMD1's ability to regulate cell growth and proliferation could be through novel interactions with key regulators of endocytosis.