MECHANISM OF NON-CLASSICAL RELEASE OF THE ANGIOGENESIS REGULATOR, IL1-ALPHA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 普鲁多夫斯基的这个项目代表了他对缺乏信号肽的蛋白质的非经典释放机制的长期生产性兴趣的一个新方向。本项目旨在研究促炎症细胞因子IL1-α的释放机制，以及该机制与促血管生成因子FGF1的不同之处。这些研究将对设计新的IL1-α和FGF1释放抑制剂具有翻译潜力和治疗意义。预计该项目将在检查GIST肿瘤或周围炎性细胞释放IL1-α方面与项目2(L.Liww)互动。该项目可以帮助开发治疗心血管和肿瘤疾病的新方法，其基础是靶向致炎和促血管生成蛋白的非经典释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project by I. Prudovsky represents a new direction for his long term productive interest in non-classical release mechanisms for proteins lacking signal peptides. This project proposes to examine the mechanism of release of the pro-inflammatory cytokine IL1-alpha, and how this mechanism differs from that of the pro-angiogenic factor FGF1. These studies will have translational potential and therapeutic implications for the design of novel inhibitors of IL1-alpha and FGF1 release. It is anticipated that this project will be interactive with Project 2 (L. Liaw) in examining the release of IL1-alpha from GIST tumors or surrounding inflammatory cells. The project can contribute to the development of new methods of treatment of cardiovascular and oncological disorders, based on targeting non-classical release of pro-inflammatory and pro-angiogenic proteins.