MECHANISM OF NON-CLASSICAL RELEASE OF THE ANGIOGENESIS REGULATOR, IL1-ALPHA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是研究促血管生成多肽FGF 1和IL 1-α的跨膜转运机制以及Notch信号转导对这些蛋白质的非经典释放的调节。 该项目与项目2（L。Liaw）在检测Notch在血管生成和癌发生的调节中的作用。该项目可以促进心血管和肿瘤疾病治疗新方法的开发，其基础是靶向促炎和促血管生成蛋白的非经典释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This goal of the project is to examine the mechanism of transmembrane translocation of pro-angiogenic polypeptides FGF1 and IL1-alpha and regulation of the non-classical release of these proteins by Notch signaling. This project is interactive with Project 2 (L. Liaw) in examining the role of Notch in the regulation of angiogenesis and carcinogenesis. The project can contribute to the development of new methods of treatment of cardiovascular and oncological disorders, based on targeting non-classical release of pro-inflammatory and pro-angiogenic proteins.