A molecular scaffold that mediates box C/D snoRNP biogenesis

介导框 C/D snoRNP 生物发生的分子支架

• 批准号: BB/F006853/1
• 负责人: Nicholas Watkins
• 金额: $ 55.09万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF006853%2F1
• 关键词: molecular; scaffold; mediates; box; snoRNP

Individual functions in the cell are harnessed and controlled, often within large molecular machines. Examples include the activities that replicate DNA, synthesise proteins and generate RNA. Correct assembly of these machines is performed in a controlled way, far from their site of function. This is important as partially or incorrectly assembled complexes are likely to interfere with the normal processes in the cell. We wish to study the assembly of one family of such cellular machines, the box C/D snoRNPs, complexes that are important for the production of the machinery that produces proteins in the cell. Our aim is to study the role of assembly factors in the formation of the box C/D snoRNPs.

细胞中的单个功能通常在大型分子机器中被利用和控制。例子包括复制DNA、合成蛋白质和产生RNA的活动。这些机器的正确装配是在远离其功能位置的受控方式下进行的。这一点很重要，因为部分或不正确组装的复合物可能会干扰细胞中的正常过程。我们希望研究这种细胞机器的一个家族的组装，盒子C/D snoRNPs，对细胞中产生蛋白质的机器的生产很重要的复合物。我们的目的是研究装配因子在盒状C/D snornp形成中的作用。

项目成果

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans.

• DOI: 10.1093/nar/gkw213
• 发表时间: 2016-06-20
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Wells GR;Weichmann F;Colvin D;Sloan KE;Kudla G;Tollervey D;Watkins NJ;Schneider C
• 通讯作者: Schneider C