权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Roles for receptor activity modifying proteins with non-traditional binding partners

受体活性修饰蛋白与非传统结合伴侣的作用

基本信息

批准号：
BB/F008392/1
负责人：
T M Skerry
金额：
$ 38.33万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FF008392%2F1
关键词：
Roles receptor activity modifying proteins

项目摘要

The communication between the cells in the body influences how our tissues are constructed and how they function. Cells signal to each other in a variety of ways, but the vast majority of signalling involves receptors / proteins that can recognise specific hormone or growth factor signalling molecules. In recent years it has been discovered that a growing number of hormone molecules do not signal to a receptor only by switching it on or off but instead, the action of the receptor on binding its hormone is altered according to the presence of a so-called receptor activity modifying protein or RAMP. Different RAMPs can either change the presence of a receptor on the cell surface, alter the hormone that can bind to a receptor or change the consequences of hormone binding. We aim to determine the specific consequences on cell signalling induced by different combinations of receptor, hormone and RAMP and to identify novel receptors that are regulated by RAMPs. We will use a combination of techniques that are currently available in Sheffield and the results of our work will provide new insights into how hormones function in the body with implications for understanding of health and disease.

体内细胞之间的交流影响着我们的组织如何构建以及它们如何发挥功能。细胞以各种方式相互传递信号，但绝大多数信号传导涉及可以识别特定激素或生长因子信号分子的受体/蛋白质。近年来，已经发现越来越多的激素分子不仅仅通过打开或关闭受体来向受体发出信号，而是根据所谓的受体活性修饰蛋白或RAMP的存在来改变受体结合其激素的作用。不同的RAMP可以改变细胞表面受体的存在，改变可以与受体结合的激素或改变激素结合的结果。我们的目的是确定特定的后果，对细胞信号诱导的不同组合的受体，激素和RAMP，并确定新的受体，RAMPs的调节。我们将结合使用目前在谢菲尔德可用的技术，我们的工作结果将为了解激素在体内的功能提供新的见解，并对理解健康和疾病产生影响。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

DOI：
10.1074/jbc.m114.624601
发表时间：
2015-09-18
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Weston C;Lu J;Li N;Barkan K;Richards GO;Roberts DJ;Skerry TM;Poyner D;Pardamwar M;Reynolds CA;Dowell SJ;Willars GB;Ladds G
通讯作者：
Ladds G

Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target.