Sleep/Wake Contiuum in Lewy Body Disease

路易体病的睡眠/觉醒连续体

• 批准号: 7430261
• 负责人: Donald L. Bliwise
• 金额: $ 33.43万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7430261
• 关键词: Behavior; Brain Stem; Clinical; Cognition; Condition; Controlled Study; Dementia; Deposition; Diagnosis; Disease; Dreams; Elderly; Elements; Environment; Excessive Daytime Sleepiness; Functional disorder; Hour; Impaired cognition; Laboratories; Lewy Bodies; Lewy Body Disease; Measurement; Measures; Motor; Parkinson Disease; Parkinsonian Disorders; Patients; Play; Polysomnography; Protocols documentation; Psyche structure; REM Sleep; Role; Science; Sleep; Sleep disturbances; Testing; Time; Work; alertness; alpha synuclein; concept; disorder control; experience; follow-up; hypocretin; insight; neurobehavioral; neurobehavioral test; novel; roentgen equivalent man

DESCRIPTION (provided by applicant): Dementia with Lewy Bodies (DLB) represents the second most common cause of dementia. The sleep/wake continuum plays an integral, though seldom explicitly recognized role in characterizing DLB, with both fluctuations in alertness and hallucinatory experiences (often accompanied by dream-enactment behaviors) considered core features of the condition. In this study, we will compare patients meeting clinical criteria for DLB (n=50), idiopathic Parkinson's Disease (IPD) (n=50) and elderly controls (n=20) to examine potential pathophysiologic mechanisms underlying these observations. Patients and controls will be studied at entry in an intensive, 72-hour laboratory protocol with polysomnographic and neurobehavioral measurements and followed-up 3 years later neurobehaviorally. Our Specific Aims are: 1) to compare polysomnographically excessive daytime sleepiness (EDS) and nocturnal sleep in DLB, IPD and controls; 2) to test whether fluctuation in mental status in DLB is related to EDS; 3) to predict whether declining cognition over 3 years is predicted by polysomnographic and neurobehavioral markers at entry. The results of this study will inform basic sleep/wake science by investigating potential substrates underlying the observed pathophysiology seen in DLB and IPD. The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism.

描述（由申请人提供）：路易体痴呆症（DLB）是痴呆症的第二大常见原因。睡眠/觉醒连续体在表征DLB中起着不可或缺的作用，尽管很少明确认识到这一点，但警觉性和幻觉体验（通常伴随着做梦行为）的波动被认为是这种情况的核心特征。在这项研究中，我们将比较符合DLB（n=50），特发性帕金森病（IPD）（n=50）和老年对照（n=20）的临床标准的患者，以检查这些观察结果的潜在病理生理机制。患者和对照组将在入组时进行密集的72小时实验室方案研究，进行多导睡眠图和神经行为测量，并在3年后进行神经行为随访。我们的具体目标是：1）比较DLB、IPD和对照组的多导睡眠图过度日间嗜睡（EDS）和夜间睡眠; 2）测试DLB中精神状态的波动是否与EDS相关; 3）预测3年以上认知下降是否通过入组时的多导睡眠图和神经行为标志物预测。本研究的结果将通过调查DLB和IPD中观察到的病理生理学的潜在底物，为基础睡眠/觉醒科学提供信息。拟议的工作也将提供重要的临床见解疾病相关性和疾病过程中广泛的帕金森氏症。