Spinal Control of Locomotion: Studies and Applications

脊髓运动控制：研究与应用

• 批准号: 7417917
• 负责人: Ilya A Rybak
• 金额: $ 43.03万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-03 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7417917
• 关键词: Acceleration; Animals; Ankle; Architecture; Biomechanics; Biomedical Engineering; Characteristics; Collaborations; Complement component C1s; Computer Simulation; Coupled; Cutaneous; Data; Data Set; Databases; Development; Disease; Electric Stimulation; Engineering; Environment; Evaluation; Feedback; Felis catus; Fiber; Fire - disasters; Flexor; Gait; Generations; Goals; Hindlimb; Hip Joint; Hip region structure; Implanted Electrodes; Individual; Injury; Institutes; Interneurons; Investigation; Joints; Kinetics; Knee; Laboratories; Lead; Length; Limb structure; Literature; Locomotion; Locomotor Recovery; Manitoba; Measurement; Measures; Medicine; Methods; Midbrain structure; Modeling; Motion; Motor Neurons; Movement; Muscle; Nerve; Neural Pathways; Operative Surgical Procedures; Pathway interactions; Pattern; Pattern Formation; Performance; Phase; Physiology; Population; Preparation; Principal Investigator; Procedures; Property; Reaction; Reflex action; Regulation; Relative (related person); Research Personnel; Rest; Role; Running; Scientist; Sensory; Series; Shapes; Shipping; Ships; Signal Transduction; Simulate; Skeletal system; Spinal; Spinal Cord; Spinal Cord transection injury; Spinal Injuries; Spinal cord injury; Staging; Suggestion; Surface; Synapses; System; Technology; Tendon force; Tendon structure; Testing; Time; Training; USA Georgia; Universities; Walking; Weight; Western Asia Georgia; base; central pattern generator; college; comparative; computational neuroscience; computer framework; deletion analysis; insight; interest; kinematics; model development; multidisciplinary; neural circuit; neuromechanism; neurophysiology; neuroregulation; programs; relating to nervous system; research study; restoration; simulation; tool

DESCRIPTION (provided by applicant): This Bioengineering Partnership brings together a multidisciplinary team of neuroscientists and engineers with complementary expertise in neural organization of the spinal cord (Dr. David McCrea, University of Manitoba), biomedical engineering and neuromuscular stimulations (Dr. Michel Lemay, Drexel University), physiology and biomechanics of locomotion (Dr. Boris Prilutsky, Georgia Institute of Technology), and computational neuroscience and neural control (Dr. llya Rybak, Drexel University). The goals of this project are (1) to perform a comprehensive multidisciplinary study of neural mechanisms in the mammalian spinal cord responsible for generation of the locomotor pattern and control of locomotion and (2) to find optimal strategies for restoring locomotor function after spinal cord injuries. In this project, two comprehensive databases will be created based on experimental studies of fictive locomotion in the decerebrate cat and on biomechanical studies of freely moving uninjured cats and spinal cats. These databases will be used for the development of (1) a computational model of neural circuitry of the spinal cord responsible for generation and control of the locomotor pattern and (2) a neuro-musculo-skeletal model of cat's locomotion. Special quantitative biomechanical criteria will be developed for evaluation of locomotor capabilities of spinal cats during and after implementation of different treatments for restoring the locomotor function. The computational models and biomechanical criteria developed will provide guidance for the applied treatments and evaluation of their results. Different strategies for the restoration of locomotor capabilities based on the combination of locomotor training on a treadmill with phase-dependent electrical stimulation of the selected sensory afferents will be implemented and investigated. The results of this project will provide significant insights into spinal mechanisms responsible for control of locomotion and will represent an important step toward the development of optimal and effective methods for restoration of locomotor function after various spinal cord injuries.

描述（由申请人提供）：该生物工程合作伙伴关系汇集了一个由神经科学家和工程师组成的多学科团队，他们在脊髓神经组织（曼尼托巴大学的 David McCrea 博士）、生物医学工程和神经肌肉刺激（德雷塞尔大学的 Michel Lemay 博士）、运动生理学和生物力学（鲍里斯博士）方面具有互补的专业知识。 Prilutsky，佐治亚理工学院），以及计算神经科学和神经控制（llya Rybak 博士，德雷克塞尔大学）。该项目的目标是（1）对哺乳动物脊髓中负责产生运动模式和控制运动的神经机制进行全面的多学科研究；（2）找到脊髓损伤后恢复运动功能的最佳策略。在该项目中，将基于对去大脑猫的虚构运动的实验研究以及对自由移动的未受伤猫和脊椎猫的生物力学研究来创建两个综合数据库。这些数据库将用于开发（1）负责生成和控制运动模式的脊髓神经回路计算模型，以及（2）猫运动的神经肌肉骨骼模型。将制定特殊的定量生物力学标准，用于评估脊髓猫在实施不同的恢复运动功能治疗期间和之后的运动能力。开发的计算模型和生物力学标准将为应用治疗和评估其结果提供指导。将实施和研究基于跑步机上的运动训练与所选感觉传入的相位依赖性电刺激相结合的运动能力恢复的不同策略。该项目的结果将为控制运动的脊柱机制提供重要的见解，并将代表着朝着开发各种脊髓损伤后恢复运动功能的最佳和有效方法迈出的重要一步。