Helminth secreted proteins – from anthelmintic vaccines to therapies for autoimmunity

蠕虫分泌的蛋白质 — 从驱虫疫苗到自身免疫疗法

• 批准号: nhmrc : 1020114
• 负责人: Prof Alexander Loukas
• 金额: $ 49.34万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/helminth-secreted-proteins-therapies-autoimmunity/110003
• 关键词: Helminth; secreted; proteins; anthelmintic; vaccines

Human helminths (worms) cause chronic disease in developing countries, yet their disappearance from developed countries has been accompanied by an increase in the prevalence of autoimmune and allergic diseases. My resesarch focuses on the proteins these worms secrete and their use in (1) the development of anthelmintic vaccines, and (2) the development of novel anti-inflammatory molecules to treat autoimmunity, particularly diseases affecting the gut.

人类蠕虫（蠕虫）在发展中国家引起慢性疾病，但它们在发达国家的消失伴随着自身免疫性和过敏性疾病流行率的增加。我的研究重点是这些蠕虫分泌的蛋白质及其在（1）驱虫疫苗的开发，和（2）开发新的抗炎分子来治疗自身免疫，特别是影响肠道的疾病中的应用。