Helminth secretomes: from vaccines to novel anti-inflammatory biologics

蠕虫分泌组：从疫苗到新型抗炎生物制剂

• 批准号: nhmrc : 1117504
• 负责人: Prof Alexander Loukas
• 金额: $ 64.07万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/helminth-secretomes-vaccines-inflammatory-biologics/946228
• 关键词: Helminth; secretomes; vaccines; novel; anti

Billions of people in developing countries are infected with parasitic worms, but they have been eradicated from industrialised nations. Humans co-evolved with worms, so their recent removal has deprived us of signals required to keep inflammation in check. My research focuses on worm molecules that can be used to (1) develop vaccines to combat these parasitic infections in developing countries, and (2) as a novel platform of anti-inflammatory therapeutics for use in industrialised nations.

发展中国家有数十亿人感染寄生蠕虫，但它们已从工业化国家根除。人类与蠕虫共同进化，所以它们最近的消失剥夺了我们控制炎症所需的信号。我的研究重点是蠕虫分子，可用于（1）开发疫苗以对抗发展中国家的寄生虫感染，以及（2）作为工业化国家使用的抗炎疗法的新平台。