A New Magnetic Resonance Imaging Console for the 7 Tesla Small Bore Animal Imaging Facility

适用于 7 特斯拉小口径动物成像设施的新型磁共振成像控制台

• 批准号: BB/F011350/1
• 负责人: Stephen Williams
• 金额: $ 28.07万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF011350%2F1
• 关键词: New; Magnetic; Resonance; Imaging; Console

This proposal to BBSRC is for new equipment to enable images to be taken of intact biological specimens ranging from isolated organs (including human heart tissue) through to living animals. The technology we will use is magnetic resonance imaging (MRI), which is a non-destructive method to take images of superb clarity and detail from within living subjects without using harmful radiation. MRI is widely used for imaging patients in hospitals, and we are proposing to purchase similar equipment for imaging much smaller subjects, such as rats and mice. One of the advantages of MRI is that it is a very versatile technique which can be used in a number of different ways / in this proposal we include three different studies of the brain: one in which we look for regions of the brain which are important in regulating appetite; another in which we are interested in where drugs which alter states of mind act; and a third in which we wish to understand how inflammation (the process by which the body responds to an infection or allergy) affects the brain. We are not restricting our study to the brain / we will also use imaging to find out about detailed structure of the heart, to discover mechanisms which lead to the formation of new blood vessels, and finally by imaging, after death, the heads of a number of specimens of different mammalian species (including some valuable samples stored in museums) we hope to improve our understanding of how mammals move and maintain their balance. The versatility of the technique means that it can be used to help provide answers to a large range of scientific questions in biology, and by this purchase we will be able to provide the opportunity to local researchers to undertake state-of-the-art imaging studies for several years to come.

向BBSRC提交的这一提案是关于新设备的，以便能够对完整的生物标本进行成像，从孤立的器官（包括人类心脏组织）到活体动物。我们将使用的技术是磁共振成像（MRI），这是一种非破坏性的方法，可以在不使用有害辐射的情况下从活体内拍摄清晰度和细节的图像。核磁共振成像广泛用于医院的病人成像，我们建议购买类似的设备，用于成像小得多的对象，如大鼠和小鼠。MRI的优点之一是它是一种非常通用的技术，可以以多种不同的方式使用/在这个建议中，我们包括三种不同的大脑研究：一种是我们寻找大脑中对调节食欲很重要的区域;另一种是我们感兴趣的改变精神状态的药物在哪里起作用;第三个是我们希望了解炎症（身体对感染或过敏反应的反应过程）如何影响大脑。我们的研究并不局限于大脑，我们还将使用成像技术来了解心脏的详细结构，发现导致新血管形成的机制，最后通过成像，在死后，不同哺乳动物的头部（包括一些保存在博物馆的珍贵样本）我们希望能增进我们对哺乳动物如何移动和保持平衡的了解。该技术的多功能性意味着它可以用于帮助提供生物学中大量科学问题的答案，通过此次购买，我们将能够为当地研究人员提供机会，在未来几年内进行最先进的成像研究。

项目成果

Differential Effects of Anaesthesia on the phMRI Response to Acute Ketamine Challenge.

麻醉对急性氯胺酮挑战的 phMRI 反应的不同影响。

• DOI: 10.9734/bjmmr/2012/1412
• 发表时间: 2012
• 期刊: British journal of medicine and medical research
• 作者: Hodkinson DJ

Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

• DOI: 10.1002/jmri.24955
• 发表时间: 2015-12
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Doblas S;Almeida GS;Blé FX;Garteiser P;Hoff BA;McIntyre DJ;Wachsmuth L;Chenevert TL;Faber C;Griffiths JR;Jacobs AH;Morris DM;O'Connor JP;Robinson SP;Van Beers BE;Waterton JC
• 通讯作者: Waterton JC

Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI.

• DOI: 10.1002/mrm.26860
• 发表时间: 2018-04
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Featherstone AK;O'Connor JPB;Little RA;Watson Y;Cheung S;Babur M;Williams KJ;Matthews JC;Parker GJM
• 通讯作者: Parker GJM