RELATIONSHIP BETWEEN DNA STRUCTURE AND ADDUCT FORMATION

DNA 结构与加合物形成之间的关系

• 批准号: 7355284
• 负责人: BARRY GOLD
• 金额: $ 0.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355284
• 关键词: RELATIONSHIP; BETWEEN; DNA; STRUCTURE; ADDUCT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The equilibrium binding and covalent interactions of carcinogens and antineoplastic agents with double-stranded DNA involves complex steric and electronic factors that are not well understood. This study will provide new and fundamental information on (a) the origin of the sequence specificity of antineoplastic DNA crosslinking agents; (b) how to design efficient DNA crosslinking agents; and (c) how the interaction of DNA with charged species, including basic amino acid sidechains, can induce DNA deformation.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。致癌物和致癌剂与双链DNA的平衡结合和共价相互作用涉及复杂的空间和电子因素，这些因素尚未得到很好的理解。这项研究将提供新的和基本的信息：（a）的序列特异性的DNA交联剂的起源;（B）如何设计有效的DNA交联剂;和（c）如何与带电物种，包括碱性氨基酸侧链的DNA的相互作用，可以诱导DNA变形。