CYCLOTRON PRODUCED ISOTOPES IN BIOLOGY & MEDICINE

回旋加速器在生物学中产生的同位素

• 批准号: 7355189
• 负责人: MICHAEL J. WELCH
• 金额: $ 0.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355189
• 关键词: CYCLOTRON; PRODUCED; ISOTOPES; BIOLOGY; MEDICINE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The chemistry core of the cyclotron project is aimed at the development of new radio-pharmaceuticals for use in positron emission tomography. A major usage of the mass spectrometry facility is in the characterization of new compounds. We typically produce new fluorinated or methylated derivatives of lead pharmaceuticals. There are then screened for the desired biological activity. Consequently mass spectrometry plays a fundamental role in this research.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。回旋加速器项目的化学核心旨在开发用于正电子发射断层扫描的新型放射性药物。质谱分析设备的一个主要用途是表征新化合物。我们通常生产新的氟化或甲基化的先导药物衍生物。然后筛选所需的生物活性。因此，质谱在这项研究中起着重要的作用。