CYCLOTRON PRODUCED ISOTOPES IN BIOLOGY & MEDICINE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The chemistry core of the cyclotron project is aimed at the development of new radio-pharmaceuticals for use in positron emission tomography. A major usage of the mass spectrometry facility is in the characterization of new compounds. We typically produce new fluorinated or methylated derivatives of lead pharmaceuticals. There are then screened for the desired biological activity. Consequently mass spectrometry plays a fundamental role in this research.