Dosimetry

剂量学核心已经在CMMI建立了大约6年。这个核心的目的是 制定CMMI申办的药代动力学和剂量学数据处理标准程序 临床试验，但这一核心也有助于CMMI的研究人员在临床前评估。核心是 负责第一个培训站点的方法，CMMI要求其成像协议， 确保所有设备，无论是在内部和外部网站，是正确的校准和维护。的 核心接收研究中心为CMMI进行的所有成像研究的数字和硬拷贝 临床方案。然后，核心将审查这些图像，并准备感兴趣的区域， 可以生成时间-活性曲线。一名训练有素的核医生和一名核医学技术专家 监督这项工作。作为一个额外的质量保证检查，CMMI也有这些数据由 合格的辐射健康物理学家（本计划项目，杰夫·西格尔博士）。这个核心也是 负责处理药代动力学数据。

The Dosimetry Core has been established at CMMI for about 6 years. The purpose of this core was to develop standard procedures for processing pharmacokinetic and dosimetry data for CMMI-sponsored clinical trials, but this core also assists investigators at CMMI in preclinical evaluation. The core is responsible for first training sites in the methodology that CMMI requires of its imaging protocols and ensures all equipment, both internally and at extramural sites, are properly calibrated and maintained. The core receives digital and hard copies of all imaging studies performed by investigational sites for CMMI clinical protocols. The core will then reviews these images and prepares regions of interest from which time-activity curves can be generated. A trained nuclear physician and a nuclear medicine technologist supervise this work. As an additional quality assurance check, CMMI also has these data reviewed by a qualified radiation health physicist (for this Program Project, Dr. Jeff Siegel). This core also is responsible for processing pharmacokinetic data.