Dosimetry

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The Dosimetry Core has been established at CMMI for about 6 years. The purpose of this core was to develop standard procedures for processing pharmacokinetic and dosimetry data for CMMI-sponsored clinical trials, but this core also assists investigators at CMMI in preclinical evaluation. The core is responsible for first training sites in the methodology that CMMI requires of its imaging protocols and ensures all equipment, both internally and at extramural sites, are properly calibrated and maintained. The core receives digital and hard copies of all imaging studies performed by investigational sites for CMMI clinical protocols. The core will then reviews these images and prepares regions of interest from which time-activity curves can be generated. A trained nuclear physician and a nuclear medicine technologist supervise this work. As an additional quality assurance check, CMMI also has these data reviewed by a qualified radiation health physicist (for this Program Project, Dr. Jeff Siegel). This core also is responsible for processing pharmacokinetic data.