Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
基本信息
- 批准号:7390618
- 负责人:
- 金额:$ 471.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-12 至 2010-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The overall long-term objective of this program project is to identify novel dietary, hormonal and genetic determinants of breast (Project 1), colorectal (Project 2), and ovarian (Project 3) cancer risk in women, with the ultimate aim of finding means for prevention and improved survival. The combination of questionnaire-derived data and biomarkers, coupled with the long-term follow-up, affords the opportunity to further understand of the time course, as well as mechanisms of cancer development. To achieve these objectives, we will relate
a) Prospectively collected data on diet, weight gain, physical activity, analgesic use, and other behaviors;
b) Nutrient and hormone levels in prospectively collected blood; and
c) Genotypic information from archived DNA and tissue blocks; to incidence of breast, colorectal, and ovarian cancers.
In addition, a fourth project will refine methods for polychotomous logistic regression and, using both a previous diet validation study and a new diet validation study, will address methodologic issues involving repeated measures of nutrients in relation to cancer risk. This project will also address causal inference and incidence modeling, as well as statistical issues in haplotype estimation and haplotype-environment interactions. Additional follow-up is required to identify adequate numbers of cases to address hypotheses outlined in each of the projects.
This program project is based on the Nurses' Health Study cohort, comprising 121,700 women who were 30 to 55 years of age when enrolled in 1976. The program project serves as the central resource for updating questionnaire data and confirming incident diseases necessary for the many related grants addressing incidence of cancer and other major chronic diseases. Thus, through funding of Cores A and B in the program project, we maintain follow-up of the cohort and timely confirmation of incident cancers and deaths. Core C conducts specimen handling and genetic analysis and Core D provides leadership and data analysis. The program project also helps to support our repository of biological samples. With this renewal application, we have an institutional commitment of $386,000 to upgrade our freezer facility.
We address three major themes across the projects. Each project will be providing either an initial assessment (ovarian cancer) or more in depth assessment (breast and colon cancers) of the role of one carbon metabolism and gene hypermethylation in carcinogenesis. Further, modeling these complex exposures will be a focus of Project 4, hence optimizing the analyses being conducted in the other three projects. The role of energy balance throughout life (as assessed through body size, physical activity, and IGF) is another focus of the three projects. The role of inflammatory markers in disease is an area of focus in both the colon and ovarian projects. Project 4 develops statistical approaches to data analysis that apply directly to Projects 1, 2, and 3 for evaluation of nutrient-cancer associations when using repeated measures of diet. Methodologic work on polychotomous logistic regression is applicable to each project as sufficient numbers of cases allow for evaluation of hypotheses relating to subsets of cancer endpoints (e.g., ductal vs., lobular breast cancer; mucinous vs. nonmucinous ovarian cancer; total cancer mortality). Furthermore, the development of methods for haplotype estimation and the evaluation of haplotype-environment interactions are applicable across each of the projects as we evaluate potential gene-environment interactions.
Strong scientific synergy permeates the projects. All projects are based on the same infrastructure of data collection, management, disease follow-up, and data analysis. The investigators, although focusing on their own areas, interact closely, which allows cross-fertilization of knowledge, ideas and approaches, and results in considerable productivity and efficiency.
描述(由申请人提供):本项目的总体长期目标是确定女性乳腺癌(项目1)、结直肠癌(项目2)和卵巢癌(项目3)风险的新的饮食、激素和遗传决定因素,最终目标是找到预防和提高生存率的方法。问卷数据和生物标志物的结合,再加上长期随访,为进一步了解癌症发展的时间进程和机制提供了机会。为了实现这些目标,我们将相互联系
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Susan E Hankinson其他文献
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
全基因组关联研究确定了与胰腺癌易感性相关的 ABO 基因座的变体
- DOI:
10.1038/ng.429 - 发表时间:
2009-08-02 - 期刊:
- 影响因子:29.000
- 作者:
Laufey Amundadottir;Peter Kraft;Rachael Z Stolzenberg-Solomon;Charles S Fuchs;Gloria M Petersen;Alan A Arslan;H Bas Bueno-de-Mesquita;Myron Gross;Kathy Helzlsouer;Eric J Jacobs;Andrea LaCroix;Wei Zheng;Demetrius Albanes;William Bamlet;Christine D Berg;Franco Berrino;Sheila Bingham;Julie E Buring;Paige M Bracci;Federico Canzian;Françoise Clavel-Chapelon;Sandra Clipp;Michelle Cotterchio;Mariza de Andrade;Eric J Duell;John W Fox Jr;Steven Gallinger;J Michael Gaziano;Edward L Giovannucci;Michael Goggins;Carlos A González;Göran Hallmans;Susan E Hankinson;Manal Hassan;Elizabeth A Holly;David J Hunter;Amy Hutchinson;Rebecca Jackson;Kevin B Jacobs;Mazda Jenab;Rudolf Kaaks;Alison P Klein;Charles Kooperberg;Robert C Kurtz;Donghui Li;Shannon M Lynch;Margaret Mandelson;Robert R McWilliams;Julie B Mendelsohn;Dominique S Michaud;Sara H Olson;Kim Overvad;Alpa V Patel;Petra H M Peeters;Aleksandar Rajkovic;Elio Riboli;Harvey A Risch;Xiao-Ou Shu;Gilles Thomas;Geoffrey S Tobias;Dimitrios Trichopoulos;Stephen K Van Den Eeden;Jarmo Virtamo;Jean Wactawski-Wende;Brian M Wolpin;Herbert Yu;Kai Yu;Anne Zeleniuch-Jacquotte;Stephen J Chanock;Patricia Hartge;Robert N Hoover - 通讯作者:
Robert N Hoover
Susan E Hankinson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Susan E Hankinson', 18)}}的其他基金
Metabolomic profile of chronic distress in relation to diseases of aging across diverse populations
不同人群中与衰老疾病相关的慢性痛苦的代谢组学特征
- 批准号:
10584230 - 财政年份:2017
- 资助金额:
$ 471.96万 - 项目类别:
Endogenous hormones and postmenopausal breast cancer: Etiologic insights and improving risk prediction
内源性激素和绝经后乳腺癌:病因学见解和改进风险预测
- 批准号:
9899942 - 财政年份:2017
- 资助金额:
$ 471.96万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8692673 - 财政年份:2012
- 资助金额:
$ 471.96万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8273845 - 财政年份:2012
- 资助金额:
$ 471.96万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8517054 - 财政年份:2012
- 资助金额:
$ 471.96万 - 项目类别:
Leadership, Administration and Statisitical Analysis
领导、管理和统计分析
- 批准号:
7786701 - 财政年份:2010
- 资助金额:
$ 471.96万 - 项目类别:
Premonopausal Hormone Levels and Risk of Breast Cancer
绝经前激素水平和乳腺癌风险
- 批准号:
7844510 - 财政年份:2009
- 资助金额:
$ 471.96万 - 项目类别:
Modifiable Risk Factors and Gene/Environment interactions in Ovarian Cancer
卵巢癌中可改变的危险因素和基因/环境相互作用
- 批准号:
6991014 - 财政年份:2004
- 资助金额:
$ 471.96万 - 项目类别:
URINARY ESTROGEN METABOLITES AND BREAST CANCER RISK
尿液雌激素代谢物与乳腺癌风险
- 批准号:
6377888 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
相似海外基金
DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
女性癌症的饮食和激素决定因素
- 批准号:
6191792 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
女性癌症的饮食和激素决定因素
- 批准号:
6475805 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
女性癌症的饮食和激素决定因素
- 批准号:
6624669 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
女性癌症的饮食和激素决定因素
- 批准号:
6408109 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
6521536 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
9098607 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
7283744 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
8071521 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
6859501 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别:
Dietary and Hormonal Determinants of Cancer in Women
女性癌症的饮食和激素决定因素
- 批准号:
8662722 - 财政年份:2000
- 资助金额:
$ 471.96万 - 项目类别: