DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN

本项目的总体长期目标是确定妇女患乳腺癌、结直肠癌和卵巢癌风险的新的饮食和激素决定因素，最终目的是找到预防和提高生存率的方法。将问卷数据与生物标志物相结合，再加上长期随访，为进一步了解癌症发展的时间进程和机制提供了机会。为了实现这些目标，我们将a)前瞻性地收集有关饮食、绝经后激素使用、吸烟和其他行为的数据；B)前瞻性采集血液中的营养和激素水平；c)存档DNA和组织块的基因分型信息；乳腺癌、结直肠癌和卵巢癌的发病率。该方案项目以护士健康研究队列为基础，该队列包括1212,700名1976年登记时年龄在30至55岁之间的妇女。该方案项目是解决这一妇女群体中出现的癌症和其他主要慢性疾病发病率的许多相关赠款的中心资源。项目1。饮食，外源性激素和乳腺癌风险。项目2。饮食、激素和结直肠癌的风险。项目3。荷尔蒙，饮食和卵巢癌的风险。项目4。风险建模中的统计创新。

The overall long-term objective of this Program Project is to identify novel dietary and hormonal determinants of breast colorectal and ovarian cancer risk in women, with the ultimate aim to find means for prevention and improved survival. The combination of questionnaire derived data with biomarkers, coupled with the long-follow-up, affords the opportunity to further understanding of the time course and mechanisms of cancer development. To achieve these objectives, we will relate a) prospectively collected data on diet, post-menopausal hormone use, smoking, and other behaviors; b) nutrient and hormone levels in prospectively collected blood; and c) genotyping information form archived DNA and tissue blocks; to incidence of breast colorectal, and ovarian cancer. This Program Project is based on the Nurses' Health Study cohort comprising 1212,700 women who were 30 to 55 years of age when enrolled in 1976. The Program Project serves as the central resource for the many related grants addressing incidence of cancer and other major chronic diseases that arise in this cohort of women. Project 1. Diet, exogenous hormones and breast cancer risk. Project 2. Diet, hormones and brisk of colorectal cancer. Project 3. Hormones, diet and risk of ovarian cancer. Project 4. Statistical innovations in risk modeling.