Imaging Core

成像核心

• 批准号: 7315097
• 负责人: Anna M Wu
• 金额: $ 9.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7315097
• 关键词: Animals; Antibodies; Archives; Area; Arts; Autoradiography; Award; Behavior; Biological; Biological Markers; Bioluminescence; Build-it; California; Cancer Detection; Capromab Pendetide; Cardiology; Cell Nucleus; Cell Proliferation; Cell surface; Clinic; Clinical; Communities; Comprehensive Cancer Center; Consultations; Data; Databases; Department of Energy; Detection; Development; Discipline of Nuclear Medicine; Disease; Doctor of Medicine; Ensure; Evaluation; Excretory function; Faculty; Fluorescence; Funding; Gene Delivery; Genes; Glucose; Glutamate Carboxypeptidase II; Goals; Grant; Housing; Image; Image Analysis; Imaging Techniques; Imaging technology; Institutes; Invasive; Investigation; Knowledge; Label; Laboratories; Leadership; Learning; Magnetic Resonance Imaging; Mainstreaming; Malignant Neoplasms; Malignant neoplasm of prostate; Medical Research; Medical center; Metabolic; Methods; Modality; Modeling; Molecular; Molecular Medicine; Monitor; Mus; Neurology; Organism; PET/CT scan; Participant; Pathway interactions; Patients; Pelvis; Physicians; Play; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Pre-Clinical Model; Prostate; Purpose; Quality Control; Radiolabeled; Radionuclide Imaging; Reporter; Reproduction spores; Research; Research Personnel; Resources; Retrieval; Rodent; Role; Schedule; Science; Sensitivity and Specificity; Services; Small Animal Imaging Resource Programs; Small Animal Imaging Systems; Sodium; Staging; System; Technology; Therapeutic Agents; Time; Tracer; Training; Transgenic Organisms; Ultrasonography; Work; Xenograft procedure; antibody engineering; base; bone; cryostat; desire; digital; fluorescence imaging; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; innovation; instrument; instrumentation; interest; investigator training; medical schools; molecular imaging; molecular/cellular imaging; mouse model; nanosystems; novel; oncology; optical imaging; pre-clinical; pre-clinical research; programs; radiotracer; research clinical testing; response; single photon emission computed tomography; treatment planning; uptake; urinary; vector

The purpose of the Imaging Core is to support the in vivo imaging needs of the projects of the UCLA SPORE in Prostate Cancer. Non-invasive imaging is a key experimental approach for studying disease in intact organisms. The Imaging Core provides functional as well as anatomical imaging technologies to SPORE investigators, at the pre-clinical and clinical level. Furthermore, the Core works closely with investigators to develop and implement new imaging tracers and technologies. Finally, centralization of these services in a Core improves the quality and reliability of imaging-based data. The goals of the Imaging Core are : 1) to provide and support state-of-the-art small animal preclinical imaging research; 2) to support innovative clinical imaging studies; and 3) to provide scientific and administrative support to Prostate SPORE investigators. Pre-clinical imaging studies are centralized in the Crump Institute imaging facility, which houses two microPET scanners, a microCT, three Xenogen IVIS optical imaging system, and a new Maestro multispectral fluorescence imager. Ancillary facilities including radiolabeling lab and rodent housing, are adjacent. In 2007 the preclinical Imaging Facility will relocate to new, spacious quarters in the California Nanosystems Institute building where it will continue to expand its offerings to investigators in oncologic molecular imaging. Clinical imaging and evaluation of novel radiolabeled tracers is supported by the Ahmanson Biological Imaging Clinic in the Geffen School of Medicine. Key aspects of the provision of imaging services are quality control and data acquision/storage/analysis, which the Imaging Core provides in order to ensure reliable access to the instrumentation and data. Lay description: One of the most exciting areas of medical research is the developing of new ways to "see" what's going on, in pre-clinical models, and ultimately in patients. Molecular imaging will provide better ways to detect cancer, and smarter ways to understand its behavior and select the most effective therapy. The Imaging Core helps all SPORE investigators to integrate imaging into their basic investigations, and to develop new ways to detect prostate cancer in patients.

成像核心的目的是支持加州大学洛杉矶分校项目的活体成像需求 前列腺癌中的孢子。非侵入性成像是研究疾病的关键实验方法 完整的有机体。成像核心提供功能和解剖成像技术，以 孢子调查员，在临床前和临床层面。此外，核心与以下方面密切合作 研究人员开发和实施新的成像示踪剂和技术。最后，集中化 核心中的这些服务提高了基于成像的数据的质量和可靠性。影像的目标 核心是：1)提供和支持最先进的小动物临床前成像研究；2)支持 创新的临床影像研究；以及3)为前列腺癌提供科学和管理支持 孢子调查员。临床前成像研究集中在克伦普研究所的成像设备中， 其中包括两台microPET扫描仪、一台microCT、三台Xenogen IVIS光学成像系统和一台新的 Maestro多光谱荧光成像仪。附属设施，包括放射性标记实验室和啮齿动物住所， 是相邻的。2007年，临床前成像设备将搬迁到加利福尼亚州的新的、宽敞的宿舍 纳米系统研究所大楼，该公司将继续在那里向肿瘤学研究人员提供服务 分子成像。新型放射性标记示踪剂的临床成像和评估由 格芬医学院的Ahmanson生物成像诊所。提供以下服务的主要方面 成像服务是质量控制和数据采集/存储/分析，成像核心在 以确保对仪器和数据的可靠访问。外行描述：最令人兴奋的 医学研究的领域是开发新的方法来“看到”临床前模型中正在发生的事情，以及 最终在病人身上。分子成像将提供更好的方法来检测癌症，以及更智能的方法来 了解它的行为并选择最有效的治疗方法。成像核心帮助所有孢子 研究人员将成像整合到他们的基础研究中，并开发新的方法来检测前列腺癌 病人中的癌症。