Imaging Core

成像核心

基本信息

批准号：
7315097
负责人：
Anna M Wu
金额：
$ 9.21万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7315097
关键词：
Animals Antibodies Archives Area Arts Autoradiography Award Behavior Biological Biological Markers Bioluminescence Build-it California Cancer Detection Capromab Pendetide Cardiology Cell Nucleus Cell Proliferation Cell surface Clinic Clinical Communities Comprehensive Cancer Center Consultations Data Databases Department of Energy Detection Development Discipline of Nuclear Medicine Disease Doctor of Medicine Ensure Evaluation Excretory function Faculty Fluorescence Funding Gene Delivery Genes Glucose Glutamate Carboxypeptidase II Goals Grant Housing Image Image Analysis Imaging Techniques Imaging technology Institutes Invasive Investigation Knowledge Label Laboratories Leadership Learning Magnetic Resonance Imaging Mainstreaming Malignant Neoplasms Malignant neoplasm of prostate Medical Research Medical center Metabolic Methods Modality Modeling Molecular Molecular Medicine Monitor Mus Neurology Organism PET/CT scan Participant Pathway interactions Patients Pelvis Physicians Play Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Pre-Clinical Model Prostate Purpose Quality Control Radiolabeled Radionuclide Imaging Reporter Reproduction spores Research Research Personnel Resources Retrieval Rodent Role Schedule Science Sensitivity and Specificity Services Small Animal Imaging Resource Programs Small Animal Imaging Systems Sodium Staging System Technology Therapeutic Agents Time Tracer Training Transgenic Organisms Ultrasonography Work Xenograft procedure antibody engineering base bone cryostat desire digital fluorescence imaging improved in vivo in vivo Cellular and Molecular Imaging Centers innovation instrument instrumentation interest investigator training medical schools molecular imaging molecular/cellular imaging mouse model nanosystems novel oncology optical imaging pre-clinical pre-clinical research programs radiotracer research clinical testing response single photon emission computed tomography treatment planning uptake urinary vector

项目摘要

The purpose of the Imaging Core is to support the in vivo imaging needs of the projects of the UCLA SPORE in Prostate Cancer. Non-invasive imaging is a key experimental approach for studying disease in intact organisms. The Imaging Core provides functional as well as anatomical imaging technologies to SPORE investigators, at the pre-clinical and clinical level. Furthermore, the Core works closely with investigators to develop and implement new imaging tracers and technologies. Finally, centralization of these services in a Core improves the quality and reliability of imaging-based data. The goals of the Imaging Core are : 1) to provide and support state-of-the-art small animal preclinical imaging research; 2) to support innovative clinical imaging studies; and 3) to provide scientific and administrative support to Prostate SPORE investigators. Pre-clinical imaging studies are centralized in the Crump Institute imaging facility, which houses two microPET scanners, a microCT, three Xenogen IVIS optical imaging system, and a new Maestro multispectral fluorescence imager. Ancillary facilities including radiolabeling lab and rodent housing, are adjacent. In 2007 the preclinical Imaging Facility will relocate to new, spacious quarters in the California Nanosystems Institute building where it will continue to expand its offerings to investigators in oncologic molecular imaging. Clinical imaging and evaluation of novel radiolabeled tracers is supported by the Ahmanson Biological Imaging Clinic in the Geffen School of Medicine. Key aspects of the provision of imaging services are quality control and data acquision/storage/analysis, which the Imaging Core provides in order to ensure reliable access to the instrumentation and data. Lay description: One of the most exciting areas of medical research is the developing of new ways to "see" what's going on, in pre-clinical models, and ultimately in patients. Molecular imaging will provide better ways to detect cancer, and smarter ways to understand its behavior and select the most effective therapy. The Imaging Core helps all SPORE investigators to integrate imaging into their basic investigations, and to develop new ways to detect prostate cancer in patients.

成像核心的目的是支持UCLA项目的体内成像需求前列腺癌中的孢子。非侵入性成像是研究疾病的关键实验方法完整的生物。成像核为功能和解剖成像技术提供孢子研究人员，临床前和临床水平。此外，核心与研究人员开发和实施新的成像示踪剂和技术。最后，集中化核心中的这些服务提高了基于成像数据的质量和可靠性。成像的目标核心是：1）提供和支持最先进的小动物临床前成像研究； 2）支持创新的临床成像研究； 3）为前列腺提供科学和行政支持孢子调查员。临床前成像研究集中在Crump Institute Imaging设施中，其中包含两个微型扫描仪，一个微型扫描仪，三个Xenogen ivis光学成像系统和一个新的大师多光谱荧光成像仪。辅助设施，包括放射线标记实验室和啮齿动物住房，相邻。 2007年，临床前成像设施将搬到加利福尼亚州的新宽敞宿舍纳米系统研究所大楼将继续将其产品扩展到肿瘤学的调查人员分子成像。新型放射性标记示踪剂的临床成像和评估由 Geffen医学院的Ahmanson生物成像诊所。提供的关键方面成像服务是质量控制和数据采集/存储/分析，成像核心提供为了确保对仪器和数据的可靠访问。外行描述：最令人兴奋的医学研究领域是开发新的方式来“查看”正在发生的事情，在临床前模型中以及最终在患者中。分子成像将提供更好的方法来检测癌症，并更聪明了解其行为并选择最有效的疗法。成像芯有助于所有孢子调查人员将成像整合到他们的基本研究中，并开发新的方法来检测前列腺患者的癌症。