Imaging Core

成像核心

• 批准号: 7315097
• 负责人: Anna M Wu
• 金额: $ 9.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7315097
• 关键词: Animals; Antibodies; Archives; Area; Arts; Autoradiography; Award; Behavior; Biological; Biological Markers; Bioluminescence; Build-it; California; Cancer Detection; Capromab Pendetide; Cardiology; Cell Nucleus; Cell Proliferation; Cell surface; Clinic; Clinical; Communities; Comprehensive Cancer Center; Consultations; Data; Databases; Department of Energy; Detection; Development; Discipline of Nuclear Medicine; Disease; Doctor of Medicine; Ensure; Evaluation; Excretory function; Faculty; Fluorescence; Funding; Gene Delivery; Genes; Glucose; Glutamate Carboxypeptidase II; Goals; Grant; Housing; Image; Image Analysis; Imaging Techniques; Imaging technology; Institutes; Invasive; Investigation; Knowledge; Label; Laboratories; Leadership; Learning; Magnetic Resonance Imaging; Mainstreaming; Malignant Neoplasms; Malignant neoplasm of prostate; Medical Research; Medical center; Metabolic; Methods; Modality; Modeling; Molecular; Molecular Medicine; Monitor; Mus; Neurology; Organism; PET/CT scan; Participant; Pathway interactions; Patients; Pelvis; Physicians; Play; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Pre-Clinical Model; Prostate; Purpose; Quality Control; Radiolabeled; Radionuclide Imaging; Reporter; Reproduction spores; Research; Research Personnel; Resources; Retrieval; Rodent; Role; Schedule; Science; Sensitivity and Specificity; Services; Small Animal Imaging Resource Programs; Small Animal Imaging Systems; Sodium; Staging; System; Technology; Therapeutic Agents; Time; Tracer; Training; Transgenic Organisms; Ultrasonography; Work; Xenograft procedure; antibody engineering; base; bone; cryostat; desire; digital; fluorescence imaging; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; innovation; instrument; instrumentation; interest; investigator training; medical schools; molecular imaging; molecular/cellular imaging; mouse model; nanosystems; novel; oncology; optical imaging; pre-clinical; pre-clinical research; programs; radiotracer; research clinical testing; response; single photon emission computed tomography; treatment planning; uptake; urinary; vector

The purpose of the Imaging Core is to support the in vivo imaging needs of the projects of the UCLA SPORE in Prostate Cancer. Non-invasive imaging is a key experimental approach for studying disease in intact organisms. The Imaging Core provides functional as well as anatomical imaging technologies to SPORE investigators, at the pre-clinical and clinical level. Furthermore, the Core works closely with investigators to develop and implement new imaging tracers and technologies. Finally, centralization of these services in a Core improves the quality and reliability of imaging-based data. The goals of the Imaging Core are : 1) to provide and support state-of-the-art small animal preclinical imaging research; 2) to support innovative clinical imaging studies; and 3) to provide scientific and administrative support to Prostate SPORE investigators. Pre-clinical imaging studies are centralized in the Crump Institute imaging facility, which houses two microPET scanners, a microCT, three Xenogen IVIS optical imaging system, and a new Maestro multispectral fluorescence imager. Ancillary facilities including radiolabeling lab and rodent housing, are adjacent. In 2007 the preclinical Imaging Facility will relocate to new, spacious quarters in the California Nanosystems Institute building where it will continue to expand its offerings to investigators in oncologic molecular imaging. Clinical imaging and evaluation of novel radiolabeled tracers is supported by the Ahmanson Biological Imaging Clinic in the Geffen School of Medicine. Key aspects of the provision of imaging services are quality control and data acquision/storage/analysis, which the Imaging Core provides in order to ensure reliable access to the instrumentation and data. Lay description: One of the most exciting areas of medical research is the developing of new ways to "see" what's going on, in pre-clinical models, and ultimately in patients. Molecular imaging will provide better ways to detect cancer, and smarter ways to understand its behavior and select the most effective therapy. The Imaging Core helps all SPORE investigators to integrate imaging into their basic investigations, and to develop new ways to detect prostate cancer in patients.

成像核心的目的是支持UCLA项目的体内成像需求 前列腺癌的治疗方法非侵入性成像是研究疾病的关键实验方法 完整的有机体Imaging Core提供功能和解剖成像技术， SPORE研究者，在临床前和临床水平。此外，核心小组还与 研究人员开发和实施新的成像示踪剂和技术。最后，中央集权 Core中的这些服务提高了基于成像的数据的质量和可靠性。成像的目标 核心是：1）提供和支持最先进的小动物临床前成像研究; 2）支持 创新的临床影像研究;及3）为前列腺科提供科学及行政支援 孢子调查员。临床前成像研究集中在Crump研究所成像设施， 它拥有两个microPET扫描仪，一个microCT，三个Xenogen IVIS光学成像系统，以及一个新的 Maestro多光谱荧光成像仪辅助设施，包括放射性标记实验室和啮齿动物饲养所， 相邻。2007年，临床前成像设施将搬迁到加州新的宽敞的宿舍 纳米系统研究所大楼，它将继续扩大其产品，以调查在肿瘤学 分子成像新型放射性标记示踪剂的临床成像和评价得到了 Ahmanson生物成像诊所在格芬医学院。提供服务的主要方面 成像服务是质量控制和数据采集/存储/分析，成像核心在 以确保对仪器和数据的可靠访问。Lay描述：最令人兴奋的之一 医学研究领域是开发新的方法来“看到”发生了什么，在临床前模型中， 最终在患者中。分子成像将提供更好的方法来检测癌症， 了解其行为并选择最有效的治疗方法。成像核心帮助所有SPORE 研究人员将成像纳入他们的基础研究，并开发新的方法来检测前列腺 癌症患者。