Imaging Core
成像核心
基本信息
- 批准号:7315097
- 负责人:
- 金额:$ 9.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAntibodiesArchivesAreaArtsAutoradiographyAwardBehaviorBiologicalBiological MarkersBioluminescenceBuild-itCaliforniaCancer DetectionCapromab PendetideCardiologyCell NucleusCell ProliferationCell surfaceClinicClinicalCommunitiesComprehensive Cancer CenterConsultationsDataDatabasesDepartment of EnergyDetectionDevelopmentDiscipline of Nuclear MedicineDiseaseDoctor of MedicineEnsureEvaluationExcretory functionFacultyFluorescenceFundingGene DeliveryGenesGlucoseGlutamate Carboxypeptidase IIGoalsGrantHousingImageImage AnalysisImaging TechniquesImaging technologyInstitutesInvasiveInvestigationKnowledgeLabelLaboratoriesLeadershipLearningMagnetic Resonance ImagingMainstreamingMalignant NeoplasmsMalignant neoplasm of prostateMedical ResearchMedical centerMetabolicMethodsModalityModelingMolecularMolecular MedicineMonitorMusNeurologyOrganismPET/CT scanParticipantPathway interactionsPatientsPelvisPhysiciansPlayPositioning AttributePositron-Emission TomographyPostdoctoral FellowPre-Clinical ModelProstatePurposeQuality ControlRadiolabeledRadionuclide ImagingReporterReproduction sporesResearchResearch PersonnelResourcesRetrievalRodentRoleScheduleScienceSensitivity and SpecificityServicesSmall Animal Imaging Resource ProgramsSmall Animal Imaging SystemsSodiumStagingSystemTechnologyTherapeutic AgentsTimeTracerTrainingTransgenic OrganismsUltrasonographyWorkXenograft procedureantibody engineeringbasebonecryostatdesiredigitalfluorescence imagingimprovedin vivoin vivo Cellular and Molecular Imaging Centersinnovationinstrumentinstrumentationinterestinvestigator trainingmedical schoolsmolecular imagingmolecular/cellular imagingmouse modelnanosystemsnoveloncologyoptical imagingpre-clinicalpre-clinical researchprogramsradiotracerresearch clinical testingresponsesingle photon emission computed tomographytreatment planninguptakeurinaryvector
项目摘要
The purpose of the Imaging Core is to support the in vivo imaging needs of the projects of the UCLA
SPORE in Prostate Cancer. Non-invasive imaging is a key experimental approach for studying disease in
intact organisms. The Imaging Core provides functional as well as anatomical imaging technologies to
SPORE investigators, at the pre-clinical and clinical level. Furthermore, the Core works closely with
investigators to develop and implement new imaging tracers and technologies. Finally, centralization of
these services in a Core improves the quality and reliability of imaging-based data. The goals of the Imaging
Core are : 1) to provide and support state-of-the-art small animal preclinical imaging research; 2) to support
innovative clinical imaging studies; and 3) to provide scientific and administrative support to Prostate
SPORE investigators. Pre-clinical imaging studies are centralized in the Crump Institute imaging facility,
which houses two microPET scanners, a microCT, three Xenogen IVIS optical imaging system, and a new
Maestro multispectral fluorescence imager. Ancillary facilities including radiolabeling lab and rodent housing,
are adjacent. In 2007 the preclinical Imaging Facility will relocate to new, spacious quarters in the California
Nanosystems Institute building where it will continue to expand its offerings to investigators in oncologic
molecular imaging. Clinical imaging and evaluation of novel radiolabeled tracers is supported by the
Ahmanson Biological Imaging Clinic in the Geffen School of Medicine. Key aspects of the provision of
imaging services are quality control and data acquision/storage/analysis, which the Imaging Core provides in
order to ensure reliable access to the instrumentation and data. Lay description: One of the most exciting
areas of medical research is the developing of new ways to "see" what's going on, in pre-clinical models, and
ultimately in patients. Molecular imaging will provide better ways to detect cancer, and smarter ways to
understand its behavior and select the most effective therapy. The Imaging Core helps all SPORE
investigators to integrate imaging into their basic investigations, and to develop new ways to detect prostate
cancer in patients.
成像核心的目的是支持UCLA项目的体内成像需求
前列腺癌的治疗方法非侵入性成像是研究疾病的关键实验方法,
完整的有机体Imaging Core提供功能和解剖成像技术,
SPORE研究者,在临床前和临床水平。此外,核心小组还与
研究人员开发和实施新的成像示踪剂和技术。最后,中央集权
Core中的这些服务提高了基于成像的数据的质量和可靠性。成像的目标
核心是:1)提供和支持最先进的小动物临床前成像研究; 2)支持
创新的临床影像研究;及3)为前列腺科提供科学及行政支援
孢子调查员。临床前成像研究集中在Crump研究所成像设施,
它拥有两个microPET扫描仪,一个microCT,三个Xenogen IVIS光学成像系统,以及一个新的
Maestro多光谱荧光成像仪辅助设施,包括放射性标记实验室和啮齿动物饲养所,
相邻。2007年,临床前成像设施将搬迁到加州新的宽敞的宿舍
纳米系统研究所大楼,它将继续扩大其产品,以调查在肿瘤学
分子成像新型放射性标记示踪剂的临床成像和评价得到了
Ahmanson生物成像诊所在格芬医学院。提供服务的主要方面
成像服务是质量控制和数据采集/存储/分析,成像核心在
以确保对仪器和数据的可靠访问。Lay描述:最令人兴奋的之一
医学研究领域是开发新的方法来“看到”发生了什么,在临床前模型中,
最终在患者中。分子成像将提供更好的方法来检测癌症,
了解其行为并选择最有效的治疗方法。成像核心帮助所有SPORE
研究人员将成像纳入他们的基础研究,并开发新的方法来检测前列腺
癌症患者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anna M Wu其他文献
Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop
利用成像工具指导免疫治疗试验:美国国家癌症研究所癌症成像指导委员会研讨会总结
- DOI:
10.1016/s1470-2045(22)00742-2 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:35.900
- 作者:
Lalitha K Shankar;Heiko Schöder;Elad Sharon;Jedd Wolchok;Michael V Knopp;Richard L Wahl;Benjamin M Ellingson;Nathan C Hall;Martin J Yaffe;Alexander J Towbin;Michael D Farwell;Daniel Pryma;Tina Young Poussaint;Chadwick L Wright;Lawrence Schwartz;Mukesh Harisinghani;Umar Mahmood;Anna M Wu;David Leung;Elisabeth G E de Vries;Steven A Reeves - 通讯作者:
Steven A Reeves
Arming antibodies: prospects and challenges for immunoconjugates
武装抗体:免疫偶联物的前景与挑战
- DOI:
10.1038/nbt1141 - 发表时间:
2005-09-07 - 期刊:
- 影响因子:41.700
- 作者:
Anna M Wu;Peter D Senter - 通讯作者:
Peter D Senter
Anna M Wu的其他文献
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{{ truncateString('Anna M Wu', 18)}}的其他基金
Engineered anti-PSCA antibodies for immunoPET and targeted therapy of pancreatic cancer
用于免疫PET和胰腺癌靶向治疗的工程化抗PSCA抗体
- 批准号:
10544038 - 财政年份:2022
- 资助金额:
$ 9.21万 - 项目类别:
Engineered anti-PSCA antibodies for immunoPET and targeted therapy of pancreatic cancer
用于免疫PET和胰腺癌靶向治疗的工程化抗PSCA抗体
- 批准号:
10343450 - 财政年份:2022
- 资助金额:
$ 9.21万 - 项目类别:
(PQC4) Imaging CD8 T Cells In Tumor Immunotherapy By Immunopet
(PQC4) 在肿瘤免疫治疗中对 CD8 T 细胞进行成像 Immunopet
- 批准号:
8928583 - 财政年份:2014
- 资助金额:
$ 9.21万 - 项目类别:
(PQC4) Imaging CD8 T Cells In Tumor Immunotherapy By Immunopet
(PQC4) 在肿瘤免疫治疗中对 CD8 T 细胞进行成像 Immunopet
- 批准号:
8791842 - 财政年份:2014
- 资助金额:
$ 9.21万 - 项目类别:
In vivo imaging of T Cells using engineered antibodies and PET
使用工程抗体和 PET 对 T 细胞进行体内成像
- 批准号:
8786848 - 财政年份:2014
- 资助金额:
$ 9.21万 - 项目类别:
Recombinant Carcinoembronic Antigen as PET Reporter Gene
重组癌胚抗原作为 PET 报告基因
- 批准号:
7039880 - 财政年份:2005
- 资助金额:
$ 9.21万 - 项目类别:
Biological Modification of Quantum Dots for in vivo Imaging
用于体内成像的量子点的生物修饰
- 批准号:
7067899 - 财政年份:2005
- 资助金额:
$ 9.21万 - 项目类别:
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