Cancer Molecular Imaging
Cancer Molecular Imaging
批准号:
7944543
负责人:
Anna M Wu
金额:
$5.35万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-02 至 2013-11-30
关键词:
Abnormal CellAddressAdvanced DevelopmentAnimal ModelAnimalsAreaArea AnalysesAttentionBiochemical ProcessBiologicalBiological ProcessCancer BiologyCancer Center Support GrantCancer DetectionCancer PatientCancer SurvivorCell CommunicationCell TherapyCellsChronicClinicClinicalClinical TreatmentClinical TrialsCollaborationsComplexDRD2 geneDetectionDevelopmentDiagnosisDisciplineDiseaseDisease ProgressionDopamineEffectivenessEngineeringEvaluationEventFosteringFundingGefitinibGene ExpressionGenomicsGiftsGlioblastomaGoalsGrantHealthHerpesvirus 1HomeostasisHumanImageImaging DeviceImaging technologyImmuneImmune responseImmunotherapyIndividualInflammationInstitutionInvestigationJonsson Comprehensive Cancer Center of University of California Los AngelesKineticsLabelLaboratoriesLeadershipLifeLiliumMalignant NeoplasmsMeasurementMeasuresMicrofluidicsModelingMolecularMolecular ProbesMolecular TargetMonitorNational Cancer InstituteOrganismPatientsPeer ReviewPhysicsPlayPositron-Emission TomographyPre-Clinical ModelPreventionProceduresProcessProteomicsPublicationsRadiolabeledReporter GenesResearch PersonnelResolutionResource SharingRodent ModelRoleScientistScreening procedureSeedsSignal TransductionSyndromeSystemT-LymphocyteTechniquesTherapeuticTracerTranslatingTranslationsTumor BiologyTumor ImmunityViralanalytical methodanalytical toolbasebody systemcancer cellcancer imagingcancer immunotherapycancer initiationcancer therapycell transformationchemobrainchemotherapyclinical applicationcostdesignimaging probeimprovedin vivoinhibitor/antagonistinnovationinsightinstrumentinstrumentationinterestmalignant breast neoplasmmathematical modelmelanomamembermolecular imagingmultimodalitynon-invasive monitornoveloncologypreclinical studypreventprogramsradiotracerresearch clinical testingresponserestorationtechnology developmenttherapeutic genetherapeutic targettherapy developmenttooltumor initiation
中文摘要
癌症分子影像计划区由18名成员组成,跨越7个部门,
加州大学洛杉矶分校在过去的竞争周期中,该计划的研究人员撰写了265篇出版物,其中232篇
(88 89项(34%)为方案间,89项(34%)为方案内。71人(27%)被安置在高影响力
ournals。该计划领域的9个成员使用了目前资助的8个共享资源中的6个
的JCCC。在本资助年度,同行评审的资金总额为440万美元,
其中包括来自国家癌症研究所的380万美元。与其他计划领域一样,JCCC促进了
许多互动活动和许多共享资源支持CMI中的研究者
程序区。在目前的赠款周期内,来自JCCC的资金以CCSG发展的形式提供,
基金,机构支持和慈善捐赠给CMI计划领域共计317,584美元。这些资金
支持种子赠款、招聘/保留和计划领域领导支持。四是方案领域
成员是JCCC支持的受益者。
分子成像是一套强大的方法,可以揭示活体的功能变化,
使人们对人类健康和疾病有了令人信服的见解。新提出的JCCC癌症分子
成像程序区汇集了共同关注采用分子成像的研究人员
研究活体癌症的工具,从实验室啮齿动物模型到患者。CMI的努力
调查人员围绕四个主题进行组织。1)仪器和分析的发展
工具.分子成像的发展需要仪器的不断发展和改进
为生物分子和过程提供更高的分辨率、灵敏度和定量测量
in vivo. 2)新型分子影像学方法的发展。CMI计划区成员已
分子成像领域的领导者,在新型示踪剂、成像基因
使用报告基因表达,开发动物模型以利用非侵入性的优势,
重复和定量成像,并在多模态成像仪器和分析的发展
程序.这些工具用于研究癌症的发生和进展、转移性扩散,
在临床前模型中对治疗的反应。3)成像免疫反应和对
免疫疗法CMI计划领域的一个重要重点是开发监测免疫的工具,
反应,并遵循癌症免疫疗法在活体个体中的效果。4)影像翻译
技术应用于癌症患者的临床环境。最终,CMI计划领域的目标是
提高对癌症的理解、检测和治疗。CMI计划区成员追求
翻译目标,包括确定目前可用的分子示踪剂的最佳使用,
诊所(例如,FDG-PET、FLT-PET)以及通过临床评价翻译新的分子示踪剂。
英文摘要
The Cancer Molecular Imaging Program Area is composed of 18 members, spanning 7 Departments within
UCLA. In the past competing cycle, investigators from this Program authored 265 publications, of which 232
(88%) were inter-programmatic and 89 (34%) intra-programmatic. 71 (27%) were placed in high-impact
ournals. Nine members of this Program Area used 6 out of the 8 Shared Resources that are currently funded
by the JCCC. During the current funding year, peer-reviewed funding totaled $4.4 million in total costs,
including $3.8 million from the National Cancer Institute. As with other Program Areas, JCCC fosters a
number of interactive activities and many of the Shared Resources that support investigators in the CMI
Program Area. During the current grant cycle, funds from the JCCC in the form of CCSG Developmental
Funds, institutional support and philanthropic gifts to the CMI Program Area total $317,584. These funds
supported Seed Grants, recruitment/retention & Program Area Leadership support. Four of the Program Area
Members were the recipients of JCCC support.
Molecular imaging is a powerful set of approaches to reveal functional changes in living subjects that has
enabled compelling insights into human health and disease. The newly proposed JCCC Cancer Molecular
Imaging Program Area brings together investigators with a common focus on employing molecular imaging
tools to investigate cancer in living individuals, from laboratory rodent models to patients. The efforts of CMI
investigators are organized around four main themes. 1) Development of instrumentation and analytical
tools. Moving molecular imaging forward requires constant development and improvement in instrumentation
to provide higher resolution, sensitivity, and quantitative measurement of biological molecules and processes
in vivo. 2) Development of novel molecular imaging approaches. CMI Program Area members have been
leaders in the field of molecular imaging, with significant contributions in novel tracers, imaging gene
expression using reporter genes, developing animal models to exploit the advantages of non-invasive,
repeated and quantitative imaging, and in development of multimodality imaging instrumentation and analytic
procedures. These tools are employed in the study of cancer initiation and progression, metastatic spread, and
response to treatment, in preclinical models. 3) Imaging immune responses and response to
immunotherapy. An important focus of the CMI Program Area is to develop the tools to monitor immune
responses and follow the effects of cancer immunotherapy in living individuals. 4) Translation of imaging
technologies to clinical contexts for cancer patients. Ultimately, the goal of the CMI Program Area is to
improve the understanding, detection, and treatment of cancer. CMI Program Area members pursue
translational goals that include both determining the best use of currently available molecular tracers in the
clinic (e.g., FDG-PET, FLT-PET) as well as translating new molecular tracers through clinical evaluation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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资助金额:$19.25万
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财政年份:2007
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依托单位:
Recombinant Carcinoembronic Antigen as PET Reporter Gene
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依托单位:
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批准号:7067899
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资助金额:$30.41万
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依托单位:
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资助金额:$18.32万
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依托单位:
海外基金