前列腺癌中的孢子-猫眼课题宝

前列腺癌中的孢子

批准号：

7281688

负责人：

DONALD J. TINDALL

金额：

$227.77万

依托单位：

MAYO CLINIC ROCHESTER

依托单位国家：

美国

项目类别：

财政年份：

2001

资助国家：

美国

项目状态：

已结题

起止时间：

2001-08-31 至 2011-08-31

来源：

https://reporter.nih.gov/project-details/7281688

关键词：

3&apos Untranslated Regions 8p22 8q24 AGR2 gene Ablation Acoustics Acute Adenocarcinoma Adenovirus Vector Adenoviruses Adjuvant Advanced Malignant Neoplasm Adverse effects Advisory Committees Advocate Affect Aftercare Algorithms Aliquot Alleles Allogenic Alternative Splicing American Americas Androgen Analogues Androgen Receptor Androgens Animal Model Animals Anterior Anthracenes Antigen Presentation Antigen-Presenting Cells Antigens Apoptosis Apoptotic Appointment Archives Area Arts Attention Attenuated Autoantigens Autoimmune Process Autologous Autologous Dendritic Cells Award BCL2 gene Base Pairing Basic Science Benign Binding Biochemical Biochemistry Bioinformatics Biological Assay Biological Markers Biological Models Biology Biomarkers and Prevention Research Branch Biopsy Biostatistics Core Biotechnology Bladder Blood Bone Marrow Brachytherapy Brachytherapy Seeds Brothers CCL20 gene CCL3 gene CD4 Positive T Lymphocytes CD8B1 gene CDKN1A gene CHEK2 gene CRISP-3 protein Calcium Channel Blockers Calcium Signaling Cancer Detection Cancer Patient Canis familiaris Caring Catechol Estrogens Cell Cycle Arrest Cell Death Cell Differentiation process Cell Line Cell Proliferation Cell Therapy Cells Centromere Cessation of life Characteristics Chemicals Chromosomal Instability Chromosomal Stability Chromosome abnormality Chromosomes Chromosomes, Human, Pair 8 Class Classification Clinic Clinical Clinical Data Clinical Endocrinology Clinical Research Clinical Trials Clinical Trials Design Cloning Cold Therapy Collaborations Collagen Type XVII Collection Colon Communities Compatible Complement Complement component C1s Complementary DNA Complex Comprehensive Cancer Center Computer software Computers Consent Control Groups Core Facility Count County Cox Proportional Hazards Models CpG Islands Cross Presentation Cryosurgery Cultured Cells Cytolysis Cytomegalovirus Cytoplasm Cytotoxic T-Lymphocytes DNA Damage DU145 Daily Data Data Analyses Data Collection Databases Dendritic Cell Vaccine Dendritic Cells Department of Defense Dermal Dermis Detection Development Dexamethasone Diagnosis Diagnostic Diagnostic Procedure Diagnostics Research Disease Disease Progression District of Columbia Doctor of Medicine Doctor of Philosophy Dose Dot Immunoblotting Double Strand Break Repair Down-Regulation Drug Formulations Drug usage Early Diagnosis Ectopic Expression Educational workshop Effectiveness Electronics Embryo End Point Endocrinology Enrollment Ensure Environment Enzymes Epidemiologic Studies Epidemiology Epithelial Epithelial Cells Epitopes Estrogens Etiology Evaluation Ewings sarcoma Excision Exhibits Exons Expressed Sequence Tags Extracellular Fluid Extramural Activities F-Box Proteins Family Family history of Fibroblasts Finland Fluorescent in Situ Hybridization Freezing Frequencies Funding Gamma Cameras Gene Delivery Gene Expression Gene Targeting Gene Transfer Generations Genes Genetic Genetic Polymorphism Genetic Transcription Genetic Variation Genets Genome Genus Cola Germany Giant Cells Gleason Grade for Prostate Cancer Glutamate Carboxypeptidase II Goals Grant Growth HLA-A2 Antigen HLA-DR1 Antigen HLA-DR13 HLA-DR15 HLA-DR53 HLA-DR9 HSV-Tk Gene Helper-Inducer T-Lymphocyte Histocompatibility Testing Homeostasis Homologous Gene Hormonal Hormones Human Human Genetics Human Glandular Kallikrein 2 Image Image Analysis Imaging Device Imaging Techniques Imiquimod Immune Immune response Immune system Immunity Immunodeficient Mouse Immunohistochemistry Immunologics Immunotherapeutic agent Immunotherapy In Situ Hybridization In Vitro In complete remission Incidence Inflammation Inflammatory Inherited Injection of therapeutic agent International Interphase Interview Invasive Investigation Iodides Iodine Journals Kininogenase Knockout Mice LNCaP Laboratories Lead Length Lesion Ligation Link Lipids Local Therapy Localized Longitudinal Studies Lymph node excision Lymphocyte Maintenance Major Histocompatibility Complex Malignant - descriptor Malignant Neoplasms Malignant neoplasm of prostate Malignant neoplasm of thyroid Manuscripts Maps Measures Mediating Medical Imaging Medical Oncology Medical Records Membrane Membrane Glycoproteins Messenger RNA Metabolic Pathway Metabolism Metastatic Neoplasm to Lymph Nodes Metastatic Prostate Cancer Methods Methylation Michigan Minnesota Mitochondrial Proteins Mitotic Mitotic Checkpoint Modality Modeling Modification Molecular Molecular Biology Techniques Molecular Profiling Mus Mutation Myelogenous NBS1 gene NOV gene Natural Killer Cells Nature Negative Lymph Node Neoplasm Metastasis Network-based Normal Cell Normal tissue morphology Nude Mice Null Lymphocytes Numbers Oligonucleotide Microarrays Oncogene Activation Oncogenes Oncogenic Operative Surgical Procedures Organ Outcome PAWR protein PC3 cell line PTEN gene PTEN protein PTGS2 gene Palliative Care Paraffin Paraffin Embedding Participant Pathologic Pathologist Pathology Pathway interactions Patient Self-Report Patients Pattern Peptide T Peptide Vaccines Peptides Perchlorates Performance Pharmaceutical Preparations Pharmacologic Substance Phase Phase I Clinical Trials Phase II Clinical Trials Phenotype Phosphoric Monoester Hydrolases Phosphorylation Physical Examination Physicians Physics Physiologic pulse Plasmids Play Polymerase Chain Reaction Population Population Sciences Postdoctoral Fellow Preparation Prevention Primary Carcinoma Primary Neoplasm Principal Investigator Procedures Process Prognostic Marker Program Development Program Evaluation Prokaryotic Initiation Factor-3 Prospective Studies Prostate Prostate Adenocarcinoma Prostate Cancer Vaccine Prostate Cancer therapy Prostate carcinoma Prostate-Specific Antigen Prostatectomy Prostatic Prostatic Epithelium Prostatic Intraepithelial Neoplasias Prostatic Neoplasms Prostatic Tissue Protein Isoforms Protein Overexpression Proteins Proteolysis Protocols documentation Publications Publishing Pulse taking Puncture biopsy Purpose Quality Control RNA RNA Splicing Radiation Radiation Dosage Radiation Oncology Radiation therapy Radical Prostatectomy Radioactive Radioactive Iodine Randomized Rate Reading Frames Recruitment Activity Recurrence Refractory Registered nurse Regulation Relapse Relative Risks Repair Complex Reporter Reporting Reproduction spores Research Research Design Research Personnel Research Project Grants Resource Sharing Resources Retropubic Prostatectomy Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Risk Risk Factors Role Rosa Route Running SLC5A5 gene Safety Sampling Schedule Science Screening for Prostate Cancer Screening procedure Secure Seeds Series Serum Services Signal Pathway Single Nucleotide Polymorphism Site Son Specialized Program of Research Excellence Specific qualifier value Specimen Staging Staining method Stains Standardization Statistically Significant Staurosporine Structure Study Subject Subcutaneous Injections Subcutaneous Tissue Support of Research Suprapubic Prostatectomy Surface Susceptibility Gene Symptoms Systemic Therapy Systemic disease T-Lymphocyte T-Lymphocyte Epitopes TP53 gene Techniques Technology Testing Therapeutic Therapeutic Effect Thyroid Gland Thyroid carcinoma Time Tissue Microarray Tissue Procurements Tissue Therapy Tissues Today Toll-like receptors Transactivation Transcript Transcriptional Activation Transducers Transfection Transgenic Mice Transgenic Organisms Translating Translational Research Translations Treatment Efficacy Tretinoin Tumor Antigens Tumor Cell Line Tumor Immunity Tumor Markers Tumor Suppression Tumor Suppressor Genes Tumor Suppressor Proteins Tumor Tissue Tumor Volume Tumor stage Tumor-Derived Tumor-Suppressor Gene Inactivation Tumorigenicity Ubiquitin Ubiquitination Ultrasonography United States United States Food and Drug Administration United States National Institutes of Health Universities Up-Regulation Upper arm Urine Urology Ursidae Family Vaccination Vaccines Validation Variant Vascular Endothelial Growth Factor C Viral Virus Replication Visit Washington Week Western Blotting Whole Cell Vaccine Withdrawal Work Xenograft procedure Xenopus Zinc Fingers abstracting adenoviral-mediated androgen independent prostate cancer anthracene anticancer research antigen processing aurora-A kinase base basolateral membrane beta-microseminoprotein c-myc Genes cancer cell cancer epidemiology cancer immunotherapy cancer risk cancer therapy carcinogenesis career cell growth cell killing cell transformation chemokine clinically significant cohort cyclooxygenase 2 cytokine cytotoxic cytotoxicity data management day demographics density deprivation design design and construction digital imaging disease-causing mutation dosimetry doxorubicin/vincristine protocol editorial effectiveness research experience expression vector follow-up forkhead protein gene therapy genetic risk factor hazard hormone refractory prostate cancer hormone therapy human SLC5A5 protein human STK6 protein human TLR7 protein human subject human tissue hyaluronan synthase 1 immunogenic immunogenicity immunoregulation implantation improved in vitro Assay in vivo innovation interest interstitial intradermal injection killings laser capture microdissection loss of function lower urinary tract symptoms lymph nodes mRNA Expression mRNA Stability macrophage scavenger receptors male malignant breast neoplasm melanocyte melanoma member men men&apos s group mibolerone migration monocyte mortality mouse model mutant neoplastic cell novel novel therapeutics nuclease oncology oncoprotein p21 outcome forecast peptide based vaccine peripheral blood plasmid DNA pre-clinical predictive modeling prevent probasin prognostic programs promoter prospective prostate surgery protein aminoacid sequence protein expression quality assurance receptor rectal research study response secretory protein sodium-iodide symporter synthetic peptide therapeutic effectiveness therapeutic gene therapeutic target therapeutic vaccine tissue registry translational approach treatment effect trend trial comparing tumor tumor progression tumorigenesis ubiquitin ligase uptake vaccination strategy vaccine development vector volunteer

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DESCRIPTION (provided by applicant): This Specialized Program of Research Excellence (SPORE) in prostate cancer at the Mayo Clinic Comprehensive Cancer Center will support an interdisciplinary team of basic, clinical, and population science investigators to perform translational research directed at significantly reducing mortality from this malignancy. Donald J. Tindall, Ph.D., will serve as the Principal Investigator and Brian J. Davis, M.D., Ph.D., will serve as Co-Principal Investigator. The translational research objectives of the SPORE will be directed by six research projects: Project 1: Utility of Serum and Tissue Biomarkers for Predicting Response to Androgen Deprivation Therapy in the Population of Men with Rising PSA Following Definitive Treatment (George G. Klee, M.D., Ph.D.), Project 2: Prostate Imaging by Vibro-acoustography (Mostafa Fatemi, Ph.D.), Project 3: Gene Therapy of Prostate Cancer Using Radioactive Iodine (John C. Morris, III, M.D.), Project 4: A Randomized Phase II Clinical Trial to Determine the Safety, Tolerability and Efficacy of an Allogeneic Whole Cell Vaccine Administered With or Without Autologous Myeloid Dendritic Cells to Patients Suffering From Androgen Independent Prostate Carcinoma (Stanimir Vuk-Pavlovic, Ph.D.), and Project 5: An Immune-Based Therapeutic Approach for Prostate Cancer (Esteban Cells, M.D., Ph.D.). Five core resources will support these research projects: Core 1: Administrative Core (Donald J. Tindall, Ph.D.), Core 2: Biospecimens Core (John C. Cheville, M.D.), Core 3: Clinical Core (Brian J. Davis, M.D., Ph.D.), Core 4: Biostatistics Core (Eric J. Bergstralh, M.S.), and Core 5: Patient Advocate Core (Donald D. Layton, Jr., M.D.) A Developmental Research Program has been established to explore opportunities for innovative research and a Career Development Program has been organized to facilitate young investigators to establish independence in prostate cancer translational research. The SPORE structure provides the ideal mechanism to focus and integrate the discovery efforts of investigators and to optimally utilize the clinical resources of the Mayo Clinic practice to continue to make meaningful advances in the management of prostate cancer.

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