The Emory-Morehouse Partnership to Reduce CV Disparities

埃默里-莫尔豪斯合作伙伴关系减少简历差异

基本信息

批准号：
7496025
负责人：
ARSHED A QUYYUMI
金额：
$ 55.75万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7496025
关键词：
Acute Address Adipose tissue Adrenal Cortex Hormones Adult Adverse effects African American Age Algorithms Angiotensinogen Animals Area Arterial Fatty Streak Arts Atherosclerosis Behavior Behavior Therapy Behavioral Bereavement Biochemical Biochemistry Biological Biological Assay Biological Factors Biological Markers Biology Biometry Blood Blood Glucose Blood Pressure Blood Tests Blood Vessels Blood specimen Body Weight decreased C-reactive protein Cardiac Cardiovascular Diseases Cardiovascular system Caring Carotid Atherosclerotic Disease Caucasians Caucasoid Race Central obesity Characteristics Chronic Chronic stress Clinical Clinical Markers Clinical Medicine Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Community Health Community Health Education Community Outreach Community Practice Complex Computers Confounding Factors (Epidemiology)Consensus Control Groups Core Facility Cross-Sectional Studies Data Data Analyses Data Collection Databases Development Diabetes Mellitus Diagnosis Diagnostic Diet Dietary intake Digit structure Discipline of Nursing Discrimination Disease Dyslipidemias Economic Factors Economics Education Educational Curriculum Effectiveness Elements Employee Strikes Enrollment Ensure Environment Epidemic Epidemiologic Studies Essential Hypertension Ethnic Origin Evaluation Event Exhibits Faculty Fasting Fatty acid glycerol esters Fibrinogen Frequencies Functional disorder Genes Genetic Glucose Glutathione Goals Guidelines HDL-triglyceride Health Health behavior High Blood Pressure High Density Lipoproteins High Prevalence Home environment Home visitation House Call Human Hylobates Genus Hyperlipidemia Hypertension Hypertriglyceridemia Incidence Individual Inflammation Inflammatory Influentials Institution Insulin Insulin Resistance Insulin Resistance Pathway Interleukin-6 Intervention Intervention Trial Iodine Isoprostanes Joint Ventures Joints Lead Leptin Life Life Style Link Lipid Peroxides Lipids Low Prevalence Measurement Measures Mediating Mediator of activation protein Mental Depression Mentors Mentorship Metabolic Metabolic syndrome Minority Modeling Modification Morbidity - disease rate National Health and Nutrition Examination Survey Natural Disasters Necrosis Needs Assessment Neighborhoods Non-Insulin-Dependent Diabetes Mellitus Nurses Nursing Students Obesity Obesity associated cardiovascular disease Observational Study Occupations Organ Other Genetics Outcome Oxidation-Reduction Oxidative Stress Participant Pathway interactions Patient Education Patient Self-Report Patients Perception Peroxidase Phase Phenotype Physiological Physiology Pilot Projects Plasma Plasminogen Inactivators Play Population Population Study Predisposition Prevalence Problem Solving Process Property Psychological Factors Psychological Stress Psychology Psychosocial Factor Psychosocial Stress Quality of Care Race Range Rate Reactive Oxygen Species Recruitment Activity Relative (related person)Research Research Infrastructure Research Personnel Resistance Resource Sharing Resources Risk Risk Assessment Risk Factors Role Sampling Self Management Series Services Site Social Aspects of Cancer Social Environment Sodium Solutions Standards of Weights and Measures Stress Structure Surrogate Markers Surveys Syndrome System Telephone Testing Therapeutic Therapeutic Intervention Thrombosis Tissues Tobacco use Training Training and Education Transcendental Meditation Translating Tumor Necrosis Factor-alpha Universities Vascular Diseases Vascular System Weight Weight maintenance regimen Welts Woman Work World Health Organization abdominal fat adipokines adiponectin age group base behavior influence biological adaptation to stress brachial artery cardiovascular disorder risk cohort coping data management design disorder risk epidemiology study ethnic difference ethnic minority population experience fitness follow-up fruits and vegetables health belief health disparity health literacy human TNF protein ilium immune function improved infancy innovation insight interest lifestyle intervention medical schools member men mortality mouse model novel organizational structure patient oriented patient registry pre-clinical pre-doctoral prognostic programs prospective psychologic psychological distress psychosocial racial difference racial discrimination repository research to practice resistin response segregation social social stress stressor therapy design waist circumference

项目摘要

DESCRIPTION (provided by applicant): Over the past decade, there has been an explosive increase in obesity among all age groups within the US population. This epidemic is particularly problematic among African-Americans in the Southeast. Although genetic factors play a contributory role, it is postulated that ethnic disparities in obesity and obesity-related cardiovascular disease (CVD) is related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities. Obesity is often associated with perturbations in the metabolic and physiologic milieu. A cluster of obesity-related abnormalities has been defined as the "Metabolic Syndrome". The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate "adipokines" that directly predispose to insulin-resistance, endothelial dysfunction, inflammation and vascular disease. The proposed program will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic, physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification. The proposed program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology, physiology, biochemistry, nursing and clinical medicine. In a thematic series of inter-related studies, our Program's research plan ranges from: epidemiology studies within the ethnic communities, to patient-centered clinical trial interventions within ethnic community practices, tothe analysis of novel biomarkers of human pathobiology. This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University. This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population that we serve. The specific aims are: Aim 1: Define the relative influence of psychosocial/cultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort. Aim 2: Define the effectiveness of patient-targeted behavioral interventions to enhance the health of African-American patients with the Metabolic Syndrome in the context of community-based clinical practices. Aim 3: To assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African-Americans. Aim 4: To enhance the education/training of fellows/practitioners engaged in CVD disparities research/practice and promote partnerships that enhance cardiovascular health within ethnic communities.

描述（由申请人提供）：在过去的十年中，美国人口中所有年龄段的肥胖症都在爆炸性增加。在东南部的非裔美国人中，这种流行病尤其有问题。尽管遗传因素起着贡献作用，但据推测，肥胖和与肥胖相关的心血管疾病（CVD）的种族差异与生物学因素之间的动态相互作用与对种族社区中独特环境环境的行为反应之间的动态相互作用有关。肥胖通常与代谢和生理环境中的扰动有关。一群与肥胖相关的异常已被定义为“代谢综合征”。肥胖的CVD并发症似乎与脂肪组织本身产生“脂肪因子”的能力有关直接易感胰岛素抵抗，内皮功能障碍，炎症和血管疾病。拟议的计划将使用最先进的方法来定义与肥胖相关的代谢，生理和生化特征以及对生活方式修改的有益反应的潜在种族差异。拟议的计划使用多学科策略来系统地表征与肥胖相关的CVD的潜在种族差异，通过利用心理学，生理学，生物化学，护理和临床医学领域。在一系列相关研究的主题系列中，我们计划的研究计划范围从：种族社区内的流行病学研究到族裔社区实践中以患者为中心的临床试验干预措施，对人类病理生物学的新生物标志物进行分析。这个合作的多入侵者团队建立在莫尔豪斯医学院和埃默里大学之间的互补伙伴关系基础上。该合作伙伴关系共同承诺解决我们服务的高风险CVD人群中的族裔差异。具体目的是：目标1：定义心理社会/文化因素和生物学介体的相对影响，是肥胖症中种族差异和代谢综合征在基于人群的双种族组中的决定因素。目标2：定义针对患者靶向行为干预措施的有效性，以增强非裔美国人患者的健康在基于社区的临床实践的背景下，代谢综合征。目标3：评估创新的生活方式干预策略对非裔美国人血管疾病风险的常规生物标志物的影响。目标4：增强从事CVD差异研究/实践的研究员/从业人员的教育/培训，并促进伙伴关系，以增强族裔社区的心血管健康。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Circulating Progenitor Cells and Racial Differences.

DOI：
10.1161/circresaha.118.313282
发表时间：
2018-08-03
期刊：
Circulation research
影响因子：
20.1
作者：
Samman Tahhan A;Hammadah M;Kelli HM;Kim JH;Sandesara PB;Alkhoder A;Kaseer B;Gafeer MM;Topel M;Hayek SS;O'Neal WT;Obideen M;Ko YA;Liu C;Hesaroieh I;Mahar E;Vaccarino V;Waller EK;Quyyumi AA
通讯作者：
Quyyumi AA