Cs-137 Irradiator for new Fitzsimons Campus

新菲茨西蒙斯校区的 Cs-137 辐照器

• 批准号: 7211852
• 负责人: David Raben
• 金额: $ 25.17万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7211852
• 关键词: Animals; Biology; Birds; Cancer Center; Cells; Clinical Trials; Collaborations; Colorado; Commit; Communities; Complex; Core Facility; Depth; Development; Dose; Faculty; Foundations; Funding; Health Sciences; Housing; Human; In Vitro; Institution; Investigation; Laws; Malignant Neoplasms; Medicine; Modeling; Mus; Pliability; Positioning Attribute; Productivity; Radiation; Radioactive; Range; Research; Research Personnel; Resources; Sheep; Site; Source; Structure; Time; Translating; Translations; United States National Institutes of Health; Universities; anticancer research; attenuation; cancer diagnosis; cost; experience; in vivo; instrument; instrumentation; irradiation; member; pre-clinical; research study; tool

DESCRIPTION (provided by applicant): A modern irradiator is an essential research tool for biology and medicine. Twelve major users are identified in this proposal that is requesting a high activity irradiator with a Cs-137 source. The instrument is made by the JL Shepherd Company, Model JL81, and included in the request are accessories required by state and federal regulatory laws. Investigators at the University of Colorado at Denver and Health Sciences Center (UCDHSC) currently use a Co-60 source that has been in place at the 9th and Colorado Blvd. campus in Denver since 1978 and is due for replacement of the radioactive source. Over 90% of the investigators that use the radiation source have moved to our new Fitzsimons campus in Aurora. The remaining faculty at the 9th Ave. campus will move to Fitzsimons by 2007, at which time the Co-60 source will be decommissioned because the cost of a new source and moving is more expensive that buying a new irradiator. A new irradiator at the Fitzsimons site will be essential for continuing the NIH-funded research of these investigators. The institution has identified space for such an instrument in Research Complex I at the Fitzsimons site. The JL81 irradiator with a Cs-137 source was selected because it has the flexibility of a wide range of in vitro and in vivo applications ranging from the irradiation of cells in culture to that of animals, from mice to sheep, and attenuation for deep dose or superficial irradiation applications. The irradiation facility will be managed as a new core facility in the University of Colorado Cancer Center (UCCC). The UCCC has 17 years of experience as a matrix cancer center and has a mature and functional structure that encourages productivity, promotes interactions and collaboration, and positions the UCCC to maximize the resources at the UCDHSC, its affiliates, and the community. The 15 major users will pursue questions integral to their NIH-funded research and the availability of this instrumentation will significantly enhance, and in many cases is crucial for, their NIH-funded research. In addition, it is expected that obtaining the JL81 irradiator and housing it at the new Fitzsimmons campus will facilitate development of new collaborations among cancer center members that will result in additional users with NIH level funding. Relevance: Obtaining funds to purchase a new JL 81 irradiator for the UCDHSC Fitzsimons campus will provide an important conduit for building upon a foundation of research related to cancer diagnosis and therapy. Many Cancer Center members with NIH funding are committed to the eradication of cancer and realize that preclinical investigations are crucial for translating findings into human clinical trials. The JL 81 irradiator is an important component of this foundation of cancer research and will facilitate the preclinical experiments necessary for translation at the new UCDHSC Fitzsimons campus.

描述（由申请人提供）：现代辐照器是生物学和医学的重要研究工具。本提案中确定了12个主要用户，它们要求使用一个铯-137源的高放射性辐照器。该仪器由JL Shepherd Company制造，型号为JL 81，申请中包括州和联邦监管法律要求的附件。位于丹佛的科罗拉多大学和健康科学中心（UCDHSC）的调查人员目前使用的钴-60源已在第9和科罗拉多大道。自1978年以来，丹佛的校园一直在使用放射源，并将更换放射源。超过90%的使用辐射源的调查人员已经搬到了我们位于奥罗拉的新菲茨西蒙斯校区。第九大道的剩余教师。到2007年，园区将搬到菲茨西蒙斯，届时钴-60源将退役，因为新的源和搬迁的成本比购买新的辐照器更昂贵。菲茨西蒙斯研究中心的一个新的辐照器对于继续这些研究人员的NIH资助的研究至关重要。该机构已确定在菲茨西蒙斯研究中心I的空间，这样一个仪器。选择具有Cs-137源的JL 81辐照器是因为它具有广泛的体外和体内应用的灵活性，从培养细胞的辐照到动物的辐照，从小鼠到绵羊，以及用于深剂量或表面辐照应用的衰减。辐照设施将作为科罗拉多大学癌症中心（UCCC）的一个新核心设施进行管理。UCCC拥有17年的矩阵癌症中心的经验，并有一个成熟的功能结构，鼓励生产力，促进互动和协作，并定位UCCC，以最大限度地利用UCDHSC，其附属公司和社区的资源。15个主要用户将继续研究NIH资助的研究中不可或缺的问题，该仪器的可用性将显着增强，在许多情况下，对NIH资助的研究至关重要。此外，预计获得JL 81辐照器并将其安置在Fitzsimmons新校区将促进癌症中心成员之间新合作的发展，这将导致更多用户获得NIH级别的资金。相关性：获得资金为UCDHSC Fitzsimons校区购买新的JL 81辐照器将为建立与癌症诊断和治疗相关的研究基础提供重要渠道。许多获得NIH资助的癌症中心成员致力于根除癌症，并意识到临床前研究对于将研究结果转化为人体临床试验至关重要。JL 81辐照器是癌症研究基础的重要组成部分，将促进新UCDHSC Fitzsimons校区翻译所需的临床前实验。