MODELLING HIPPOCAMPUS SUB-STRUCTURES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们小组最近开发了一些专门用于TLE和AD患者的海马-杏仁核复合体的分割工具，这些工具来自基本的临床MR图像(Chupin等人，ISBI2002)。我们对使用脑磁图探测这些更深层次的结构很感兴趣。我们在脑磁图上同时记录的植入癫痫患者的最新数据表明，这是非常有希望的。我们的工具对海马体和杏仁核包膜进行一些自动分割。现在我们想要开发海马体详细内部结构的通用模型。我们的想法是获得海马体的3D模板，带有标记的子结构，我们将变形和翘曲到我们将从单个MRS中提取的单独的包膜。我们遇到了Toga教授1994年和1997年关于冷冻人脑的论文，并认为您使用的部分数据可能会引起我们的极大兴趣。我们可以手动精确地描绘我们感兴趣的结构(海马体、杏仁核和邻近的皮质，1997年的论文中已经描述的东西)，并在我们的神经解剖学家专家的帮助下通过标记一些感兴趣的子结构来进一步推动这一点。3D镶嵌模型可以与从我们的分割工具获得的总体包络一起设计。这些物体将变成一个3D模板，可以弯曲到从磁共振扫描中提取的单个信封上。这个与Loni合作的项目需要我们获得其中一个冷冻大脑的高分辨率图片，以及Loni数据库中的3D重建。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our group has recently developed some segmentation tools dedicated to the hippocampus-amygdala complex in TLE and AD patients from basic clinical MR images (Chupin et al., ISBI2002). We're interested in detecting these deeper structures using MEG. Recent data we've acquired with implanted epileptic patients recorded simultaneously in MEG indicate this is very promising. Our tools run some automatic segmentation of the hippocampus and amygdala envelopes. Now we would like to develop generic models of the hippocampus detailed inner structure. Our idea is to obtain a 3D template of the hippocampus, with labelled sub-structures, that we would deform and warp to the individual envelope we would extract from individual MRs. We came accross Prof Toga's 1994 and 1997 papers dealing with the cryosectioned human brains and thought part of the data you've been using could be of great interest to us. We could precisely delineate manually the structures we are interested in (Hippocampus, Amygdala and adjacent cortices, things that are already described in the 1997 paper) and push this a bit further by labelling some sub-structures of interest with the help of our neuroanatomist expert. 3D tessellated models could be designed together with the overall envelope obtained from our segmentation tool. These objects would become a 3D template that could be warped to the individual envelope extracted from an MR scan.This collaborative project with LONI requires we gain access to the high-resolution pictures of one of the cryosectioned brains and of its 3D reconstruction in LONI's database.