AMINO TERMINAL DOMAIN OF IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT TYPE 2 (G2-ATD)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ionotropic glutamate receptors are oligomeric ligand-gated ion channels responsible for mediating fast excitatory neurotransmission in the brain. The large extracellular domain is composed of an amino terminal domain (ATD) and a ligand-binding domain (S1S2). Although the role of S1S2 has been failry well delineated, the purpose of the ATD is less clear. However, it is thought to mediate receptor assembly, contribute to dendritic spine formation, and participate in receptor trafficking. The three-dimensional structure of ATD would help clarify some issues regarding assembly and perhaps even putative interactions with synaptic targeting proteins.