CRYSTALLOGRAPHIC STUDIES OF TRANSPORTERS AND RECEPTORS

转运体和受体的晶体学研究

• 批准号: 7722058
• 负责人: James E Gouaux
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722058
• 关键词: Aspartate; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Gated Ion Channel; Grant; Institution; Integral Membrane Protein; Ion Channel Protein; L-Selenomethionine; Leucine; Ligands; Phase; Research; Research Personnel; Resolution; Resources; Source; United States National Institutes of Health; receptor; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have crystals of multiple integral membrane protein transporters and ligand-gated ion channel receptors that include the GltPh aspartate transporter, LeuT leucine transporter and two eukaryotic ligand-gated ion channels for which there is currently no high resolution structural data. We aim to carry out specific mechanistics studies on GltPh and LeuT and to perform MAD (SeMet) experiments on the two ligand-gated ion channel proteins in order to solve the phase problem.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们有多种完整的膜蛋白转运体和配体门控离子通道受体的晶体，其中包括GltPh天冬氨酸转运体、亮氨酸转运体和两个真核配体门控离子通道，目前还没有高分辨结构数据。我们的目标是对GltPh和Leut进行特定的机理研究，并对这两种配体门控离子通道蛋白进行MAD(Semet)实验，以解决相问题。